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MEK_UP.V1_DN

GeneID Mean_1 Mean_3 StDev_1 StDev_3 T-Statistic p-value SymbolDescription
1 4886 7.6 10.3 0.7 0.4 5.676 0.0114 NPY1R neuropeptide Y receptor Y1
2 5174 9.6 11.1 0.7 0.3 3.346 0.0456 PDZK1 PDZ domain containing 1
3 3434 8.9 14.0 0.7 0.9 7.551 0.0020 IFIT1 interferon-induced protein with tetratricopeptide repeats 1
4 4256 12.8 11.6 0.8 0.5 -2.222 0.1005 MGP matrix Gla protein
5 9687 9.0 11.0 0.2 0.2 13.051 0.0002 GREB1 growth regulation by estrogen in breast cancer 1
6 2674 13.9 12.9 0.3 0.3 -3.880 0.0189 GFRA1 GDNF family receptor alpha 1
7 4071 10.9 10.6 0.3 1.2 -0.425 0.7075 TM4SF1 transmembrane 4 L six family member 1
8 3429 6.8 16.2 1.5 0.2 10.972 0.0071 IFI27 interferon, alpha-inducible protein 27
9 26353 10.7 11.6 0.2 0.0 8.806 0.0088 HSPB8 heat shock 22kDa protein 8
10 51133 10.6 10.8 0.1 0.0 2.006 0.1646 KCTD3 potassium channel tetramerization domain containing 3
11 23586 6.6 8.0 0.2 0.2 7.882 0.0014 DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
12 8334 8.7 8.3 0.2 0.1 -3.850 0.0366 HIST1H2AC histone cluster 1, H2ac
13 684 12.9 14.3 0.2 0.1 8.827 0.0058 BST2 bone marrow stromal cell antigen 2
14 10395 5.8 6.2 0.2 0.2 2.854 0.0464 DLC1 DLC1 Rho GTPase activating protein
15 11254 2.6 10.8 0.8 0.3 15.953 0.0013 SLC6A14 solute carrier family 6 (amino acid transporter), member 14
16 22836 10.4 11.8 0.3 0.1 7.422 0.0118 RHOBTB3 Rho-related BTB domain containing 3
17 5577 9.5 8.9 0.0 0.1 -9.459 0.0050 PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
18 9246 9.5 10.3 0.2 0.4 2.951 0.0593 UBE2L6 ubiquitin-conjugating enzyme E2L 6
19 10561 5.0 12.1 0.1 0.5 22.157 0.0011 IFI44 interferon-induced protein 44
20 1960 4.6 5.3 0.8 1.0 1.002 0.3749 EGR3 early growth response 3
21 2537 8.7 14.8 1.0 0.7 8.433 0.0017 IFI6 interferon, alpha-inducible protein 6
22 4602 9.2 9.5 0.2 0.4 1.283 0.2904 MYB v-myb avian myeloblastosis viral oncogene homolog
23 1836 8.0 12.7 0.2 0.6 13.750 0.0018 SLC26A2 solute carrier family 26 (anion exchanger), member 2
24 64135 9.2 10.9 0.2 0.6 5.160 0.0215 IFIH1 interferon induced with helicase C domain 1
25 26018 12.2 12.2 0.5 0.2 -0.020 0.9856 LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
26 3431 9.6 10.9 0.2 0.2 6.699 0.0026 SP110 SP110 nuclear body protein
27 10964 2.4 11.5 0.5 0.9 15.974 0.0004 IFI44L interferon-induced protein 44-like
28 6445 10.4 8.2 0.3 0.7 -5.004 0.0192 SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
29 55197 10.4 10.3 0.0 0.2 -0.786 0.5042 RPRD1A regulation of nuclear pre-mRNA domain containing 1A
30 55008 2.1 6.6 0.1 0.9 8.223 0.0142 HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
31 4477 5.5 9.1 0.6 0.1 10.135 0.0068 MSMB microseminoprotein, beta-
32 3398 12.0 12.5 0.5 0.4 1.419 0.2315 ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
33 26053 6.1 4.7 0.1 0.1 -12.289 0.0003 AUTS2 autism susceptibility candidate 2
34 2852 10.6 10.8 0.4 0.2 0.545 0.6181 GPER1 G protein-coupled estrogen receptor 1
35 4938 2.5 8.5 0.3 0.7 14.698 0.0014 OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
36 55601 5.1 9.9 1.3 0.7 5.687 0.0088 DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
37 57535 13.3 14.3 0.4 0.4 2.998 0.0401 KIAA1324 KIAA1324
38 3800 8.9 6.3 0.5 0.1 -9.072 0.0098 KIF5C kinesin family member 5C
39 3006 13.9 13.5 0.0 0.1 -10.343 0.0027 HIST1H1C histone cluster 1, H1c
40 596 10.3 10.3 0.2 0.1 0.739 0.5268 BCL2 B-cell CLL/lymphoma 2
41 8357 9.7 9.7 0.1 0.1 -0.097 0.9272 HIST1H3H histone cluster 1, H3h
42 8339 10.0 9.9 0.1 0.2 -0.343 0.7529 HIST1H2BG histone cluster 1, H2bg
43 3665 11.1 13.4 0.2 0.3 10.943 0.0011 IRF7 interferon regulatory factor 7
44 23314 7.1 6.3 0.2 0.1 -5.888 0.0142 SATB2 SATB homeobox 2
45 8839 10.7 12.5 0.2 0.2 10.979 0.0004 WISP2 WNT1 inducible signaling pathway protein 2
46 445 12.9 13.1 0.5 0.0 0.535 0.6454 ASS1 argininosuccinate synthase 1
47 51309 9.3 7.1 0.2 0.2 -17.561 0.0001 ARMCX1 armadillo repeat containing, X-linked 1
48 11274 8.7 10.6 0.1 0.6 5.773 0.0240 USP18 ubiquitin specific peptidase 18
49 323 8.8 8.3 0.3 0.1 -2.424 0.1169 APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
50 79068 8.4 8.6 0.1 0.3 0.667 0.5576 FTO fat mass and obesity associated
51 51566 8.3 7.7 0.1 0.1 -6.308 0.0036 ARMCX3 armadillo repeat containing, X-linked 3
52 4940 5.0 9.1 0.1 0.7 9.854 0.0086 OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
53 4638 5.9 5.6 0.1 0.4 -1.376 0.2782 MYLK myosin light chain kinase
54 9636 13.4 16.4 0.2 0.7 6.947 0.0136 ISG15 ISG15 ubiquitin-like modifier
55 54981 9.9 9.7 0.1 0.3 -0.903 0.4392 NMRK1 nicotinamide riboside kinase 1
56 178 9.1 9.2 0.4 0.1 0.458 0.6825 AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
57 8345 13.0 13.1 0.1 0.1 0.932 0.4120 HIST1H2BH histone cluster 1, H2bh
58 51427 7.5 9.2 0.4 0.3 5.556 0.0064 ZNF107 zinc finger protein 107
59 6814 11.9 11.8 0.2 0.1 -0.488 0.6582 STXBP3 syntaxin binding protein 3
60 55034 10.0 9.3 0.3 0.1 -4.533 0.0224 MOCOS molybdenum cofactor sulfurase
61 84909 7.9 6.5 0.0 0.6 -4.191 0.0523 C9orf3 chromosome 9 open reading frame 3
62 7035 5.2 4.4 0.5 0.1 -2.646 0.1084 TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
63 4603 7.8 7.8 0.1 0.4 0.182 0.8694 MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
64 9039 7.7 7.9 0.2 0.1 1.138 0.3478 UBA3 ubiquitin-like modifier activating enzyme 3
65 6744 9.6 9.9 0.0 0.2 3.273 0.0661 SSFA2 sperm specific antigen 2
66 24138 8.9 10.9 0.2 0.5 6.739 0.0090 IFIT5 interferon-induced protein with tetratricopeptide repeats 5
67 57698 7.8 7.7 0.0 0.1 -2.018 0.1604 KIAA1598 KIAA1598
68 6947 2.7 4.2 0.3 0.4 5.030 0.0090 TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
69 10924 9.1 9.7 0.0 0.2 4.248 0.0489 SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
70 11201 9.3 9.5 0.2 0.2 1.176 0.3050 POLI polymerase (DNA directed) iota
71 8204 10.4 11.3 0.5 0.3 2.949 0.0577 NRIP1 nuclear receptor interacting protein 1
72 55119 9.8 10.2 0.3 0.5 1.254 0.2920 PRPF38B pre-mRNA processing factor 38B
73 4609 8.9 8.0 0.4 0.6 -2.174 0.1053 MYC v-myc avian myelocytomatosis viral oncogene homolog
74 58155 9.5 9.7 0.1 0.1 3.017 0.0393 PTBP2 polypyrimidine tract binding protein 2
75 26154 6.0 9.3 0.7 0.4 6.692 0.0049 ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12
76 8344 8.8 9.2 0.2 0.4 1.728 0.1983 HIST1H2BE histone cluster 1, H2be
77 57234 8.1 10.4 0.2 0.2 13.301 0.0002 LINC00869 long intergenic non-protein coding RNA 869
78 466 10.6 11.0 0.1 0.2 2.828 0.0517 ATF1 activating transcription factor 1
79 79675 10.4 10.3 0.2 0.2 -1.223 0.2905 FASTKD1 FAST kinase domains 1
80 23015 7.1 7.5 0.2 0.1 3.133 0.0396 GOLGA8A golgin A8 family, member A
81 3983 9.5 8.9 0.2 0.2 -3.762 0.0198 ABLIM1 actin binding LIM protein 1
82 89927 8.2 8.1 0.1 0.6 -0.251 0.8243 C16orf45 chromosome 16 open reading frame 45
83 3430 9.3 10.0 0.2 0.4 3.386 0.0439 IFI35 interferon-induced protein 35
84 23475 12.1 12.8 0.1 0.1 6.978 0.0022 QPRT quinolinate phosphoribosyltransferase
85 4092 9.4 9.1 0.1 0.3 -1.823 0.2014 SMAD7 SMAD family member 7
86 8416 12.8 9.8 0.1 0.2 -19.271 0.0005 ANXA9 annexin A9
87 8365 11.9 11.9 0.1 0.1 0.050 0.9626 HIST1H4H histone cluster 1, H4h
88 55005 11.6 10.1 0.1 0.3 -8.996 0.0055 RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae)
89 22996 8.8 9.3 0.1 0.2 3.483 0.0402 TTC39A tetratricopeptide repeat domain 39A
90 347902 10.5 10.0 0.9 0.1 -1.015 0.4120 AMIGO2 adhesion molecule with Ig-like domain 2
91 29919 8.6 8.7 0.2 0.4 0.179 0.8708 C18orf8 chromosome 18 open reading frame 8
92 8777 8.3 7.8 0.2 0.0 -3.285 0.0783 MPDZ multiple PDZ domain protein
93 429 2.8 2.2 0.5 0.0 -2.009 0.1818 ASCL1 achaete-scute family bHLH transcription factor 1
94 56603 2.9 2.7 0.8 0.4 -0.442 0.6889 CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
95 4939 4.3 9.3 0.4 0.7 10.541 0.0010 OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
96 3480 12.9 12.8 0.3 0.2 -0.296 0.7828 IGF1R insulin-like growth factor 1 receptor
97 29887 7.7 8.5 0.2 0.1 6.994 0.0068 SNX10 sorting nexin 10
98 55035 12.1 11.9 0.1 0.0 -2.326 0.1325 NOL8 nucleolar protein 8
99 6279 6.2 8.3 1.2 1.0 2.394 0.0770 S100A8 S100 calcium binding protein A8
100 7699 2.3 2.6 0.3 0.8 0.627 0.5841 ZNF140 zinc finger protein 140
101 3717 7.8 9.0 0.2 0.4 5.183 0.0187 JAK2 Janus kinase 2
102 10388 7.4 7.0 0.5 0.4 -1.003 0.3762 SYCP2 synaptonemal complex protein 2
103 1475 4.5 6.5 0.4 0.6 5.068 0.0098 CSTA cystatin A (stefin A)
104 54995 11.7 11.5 0.1 0.1 -2.995 0.0418 OXSM 3-oxoacyl-ACP synthase, mitochondrial
105 10379 7.2 10.0 0.4 0.3 10.542 0.0006 IRF9 interferon regulatory factor 9
106 8519 11.3 15.3 0.1 0.5 13.877 0.0045 IFITM1 interferon induced transmembrane protein 1
107 55032 8.4 8.2 0.1 0.1 -2.588 0.0984 SLC35A5 solute carrier family 35, member A5
108 54894 11.9 12.7 0.2 0.2 5.434 0.0066 RNF43 ring finger protein 43
109 27250 10.5 10.4 0.2 0.4 -0.739 0.5165 PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
110 5378 6.9 7.0 0.1 0.1 1.654 0.1750 PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
111 9871 8.4 9.2 0.4 0.2 3.470 0.0379 SEC24D SEC24 family member D
112 4528 7.4 6.9 0.5 0.2 -1.741 0.1942 MTIF2 mitochondrial translational initiation factor 2
113 794 2.7 4.9 0.4 1.1 3.064 0.0673 CALB2 calbindin 2
114 79868 10.1 10.4 0.1 0.1 3.141 0.0361 ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit
115 9317 7.1 7.9 0.2 0.1 6.996 0.0084 PTER phosphotriesterase related
116 79071 8.1 8.5 0.2 0.1 2.689 0.0741 ELOVL6 ELOVL fatty acid elongase 6
117 60481 9.1 10.0 0.4 0.1 4.084 0.0467 ELOVL5 ELOVL fatty acid elongase 5
118 5723 11.2 10.7 0.4 0.1 -2.355 0.1235 PSPH phosphoserine phosphatase
119 23424 9.6 9.7 0.2 0.1 1.378 0.2413 TDRD7 tudor domain containing 7
120 9120 9.3 9.0 0.4 0.4 -0.856 0.4415 SLC16A6 solute carrier family 16, member 6
121 1123 8.8 9.1 0.3 0.2 1.255 0.2859 CHN1 chimerin 1
122 8934 8.8 7.8 0.3 0.1 -5.447 0.0261 RAB29 RAB29, member RAS oncogene family
123 22824 8.4 8.1 0.2 0.5 -0.867 0.4577 HSPA4L heat shock 70kDa protein 4-like
124 2803 10.0 10.0 0.1 0.2 0.465 0.6677 GOLGA4 golgin A4
125 22876 7.1 7.1 0.0 0.1 -0.078 0.9422 INPP5F inositol polyphosphate-5-phosphatase F
126 29889 11.7 11.9 0.1 0.2 1.338 0.2607 GNL2 guanine nucleotide binding protein-like 2 (nucleolar)
127 9315 9.4 8.9 0.2 0.4 -1.935 0.1533 NREP neuronal regeneration related protein
128 2161 14.0 14.7 0.2 0.1 4.536 0.0294 F12 coagulation factor XII (Hageman factor)
129 64860 10.4 10.6 0.2 0.1 1.539 0.2506 ARMCX5 armadillo repeat containing, X-linked 5
130 22834 11.5 11.3 0.1 0.4 -0.968 0.4263 ZNF652 zinc finger protein 652
131 51690 14.1 14.6 0.3 0.0 2.677 0.1156 LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
132 55827 8.5 8.9 0.1 0.2 3.093 0.0472 DCAF6 DDB1 and CUL4 associated factor 6
133 84869 10.0 9.6 0.2 0.1 -2.765 0.0514 CBR4 carbonyl reductase 4
134 7290 11.5 11.5 0.1 0.2 0.504 0.6476 HIRA histone cell cycle regulator
135 29994 7.7 7.7 0.2 0.1 0.880 0.4418 BAZ2B bromodomain adjacent to zinc finger domain, 2B
136 55081 4.4 3.7 0.3 0.3 -2.859 0.0469 IFT57 intraflagellar transport 57
137 7155 13.4 13.5 0.0 0.1 1.976 0.1622 TOP2B topoisomerase (DNA) II beta 180kDa
138 8969 4.8 3.9 0.7 1.2 -1.204 0.3091 HIST1H2AG histone cluster 1, H2ag
139 9935 8.0 10.3 0.5 0.1 8.079 0.0114 MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
140 10125 6.3 7.2 0.6 0.2 2.397 0.1169 RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
141 7980 7.0 6.2 0.3 0.2 -3.768 0.0224 TFPI2 tissue factor pathway inhibitor 2
142 79887 10.2 10.2 0.1 0.1 -0.367 0.7391 PLBD1 phospholipase B domain containing 1
143 65986 6.1 7.3 0.5 0.3 3.361 0.0469 ZBTB10 zinc finger and BTB domain containing 10
144 7637 9.7 9.9 0.1 0.3 1.146 0.3539 ZNF84 zinc finger protein 84
145 4338 10.1 11.1 0.2 0.2 6.424 0.0031 MOCS2 molybdenum cofactor synthesis 2
146 26046 5.1 5.2 0.2 0.2 0.640 0.5591 LTN1 listerin E3 ubiquitin protein ligase 1
147 55768 12.4 11.8 0.1 0.2 -5.013 0.0079 NGLY1 N-glycanase 1
148 9665 11.8 11.5 0.2 0.1 -2.339 0.1273 KIAA0430 KIAA0430
149 8346 11.8 11.7 0.2 0.0 -1.746 0.2195 HIST1H2BI histone cluster 1, H2bi
150 51012 11.7 11.9 0.1 0.1 2.745 0.0536 SLMO2 slowmo homolog 2 (Drosophila)
151 29760 7.6 7.8 0.1 0.2 1.782 0.1850 BLNK B-cell linker
152 467 6.5 6.1 0.2 0.3 -1.669 0.1843 ATF3 activating transcription factor 3
153 23255 5.6 6.3 0.7 0.4 1.609 0.2070 MTCL1 microtubule crosslinking factor 1
154 5205 10.5 10.6 0.3 0.1 0.370 0.7423 ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
155 64431 10.7 11.3 0.1 0.1 5.993 0.0063 ACTR6 ARP6 actin-related protein 6 homolog (yeast)
156 6672 8.8 10.3 0.2 0.3 7.708 0.0023 SP100 SP100 nuclear antigen
157 5121 13.9 8.7 0.3 0.3 -21.552 0.0000 PCP4 Purkinje cell protein 4
158 841 5.6 6.3 0.3 0.2 2.697 0.0646 CASP8 caspase 8, apoptosis-related cysteine peptidase
159 54665 10.4 10.4 0.2 0.1 0.060 0.9555 RSBN1 round spermatid basic protein 1
160 9926 10.2 10.3 0.0 0.1 2.541 0.0785 LPGAT1 lysophosphatidylglycerol acyltransferase 1
161 56339 11.5 12.3 0.1 0.0 15.386 0.0019 METTL3 methyltransferase like 3
162 7594 3.9 3.9 0.1 0.2 0.245 0.8228 ZNF43 zinc finger protein 43
163 3375 5.6 4.4 0.2 0.4 -4.764 0.0194 IAPP islet amyloid polypeptide
164 8821 8.9 9.4 0.5 0.4 1.117 0.3297 INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
165 25913 8.4 8.4 0.1 0.3 -0.030 0.9788 POT1 protection of telomeres 1
166 253959 8.6 8.1 0.1 0.1 -5.431 0.0057 RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
167 10813 9.5 9.6 0.2 0.2 0.599 0.5818 UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
168 51141 8.0 7.8 0.3 0.4 -0.545 0.6161 INSIG2 insulin induced gene 2
169 799 3.2 3.0 0.5 0.2 -0.571 0.6124 CALCR calcitonin receptor
170 8638 8.9 10.0 0.1 1.1 1.779 0.2158 OASL 2'-5'-oligoadenylate synthetase-like
171 5241 10.2 11.5 0.2 0.1 9.929 0.0013 PGR progesterone receptor
172 9562 7.0 7.7 0.3 0.1 3.567 0.0400 MINPP1 multiple inositol-polyphosphate phosphatase 1
173 25939 5.4 6.5 0.2 0.5 3.848 0.0428 SAMHD1 SAM domain and HD domain 1
174 6873 9.6 10.4 0.2 0.1 6.471 0.0046 TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
175 221037 8.1 8.4 0.1 0.1 5.463 0.0110 JMJD1C jumonji domain containing 1C
176 90806 8.1 7.6 0.0 0.1 -12.211 0.0007 ANGEL2 angel homolog 2 (Drosophila)
177 2581 6.9 8.2 0.2 0.1 10.500 0.0039 GALC galactosylceramidase
178 1070 10.0 10.4 0.2 0.1 2.583 0.1088 CETN3 centrin, EF-hand protein, 3
179 10905 10.4 10.0 0.1 0.1 -5.554 0.0061 MAN1A2 mannosidase, alpha, class 1A, member 2
180 9716 7.9 8.9 0.2 0.0 8.602 0.0098 AQR aquarius intron-binding spliceosomal factor
181 1299 12.7 9.7 0.1 0.5 -10.830 0.0063 COL9A3 collagen, type IX, alpha 3
182 3012 11.7 11.1 0.2 0.1 -5.519 0.0175 HIST1H2AE histone cluster 1, H2ae
183 6938 2.5 7.8 0.5 0.2 18.459 0.0005 TCF12 transcription factor 12
184 7456 3.8 5.4 0.3 0.1 7.780 0.0132 WIPF1 WAS/WASL interacting protein family, member 1
185 6890 10.1 11.3 0.1 0.5 4.168 0.0505 TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
186 9830 7.9 8.5 0.1 0.2 4.383 0.0125 TRIM14 tripartite motif containing 14
187 8343 8.9 9.1 0.2 0.4 0.493 0.6565 HIST1H2BF histone cluster 1, H2bf
188 6658 8.0 12.2 0.1 0.2 34.471 0.0000 SOX3 SRY (sex determining region Y)-box 3
189 10196 9.2 8.9 0.1 0.3 -1.556 0.2444 PRMT3 protein arginine methyltransferase 3
190 9520 11.3 10.5 0.1 0.2 -6.973 0.0030 NPEPPS aminopeptidase puromycin sensitive
191 2218 5.9 5.3 0.1 0.3 -4.015 0.0321 FKTN fukutin
192 54332 8.9 4.5 0.2 0.4 -17.423 0.0003 GDAP1 ganglioside induced differentiation associated protein 1
193 51103 10.4 11.3 0.3 0.1 5.061 0.0212 NDUFAF1 NADH dehydrogenase (ubiquinone) complex I, assembly factor 1