Fig 1: Enrichment plot: TOPIRAMATE
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | GE_agg.GE_agg.cls#LTED_versus_MCF7p.GE_agg.cls#LTED_versus_MCF7p_repos |
| Phenotype | GE_agg.cls#LTED_versus_MCF7p_repos |
| Upregulated in class | MCF7p |
| GeneSet | TOPIRAMATE |
| Enrichment Score (ES) | -0.43824026 |
| Normalized Enrichment Score (NES) | -1.2996404 |
| Nominal p-value | 0.09033614 |
| FDR q-value | 1.0 |
| FWER p-Value | 1.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | 2556 | NA | GABRA3 Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, alpha 3 | 156 | 1.460 | 0.0856 | No |
| 2 | 23632 | NA | CA14 Entrez, Source | carbonic anhydrase XIV | 296 | 1.062 | 0.1468 | No |
| 3 | 2562 | NA | GABRB3 Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, beta 3 | 1170 | 0.508 | 0.1393 | No |
| 4 | 6323 | NA | SCN1A Entrez, Source | sodium channel, voltage gated, type I alpha subunit | 1300 | 0.478 | 0.1638 | No |
| 5 | 763 | NA | CA5A Entrez, Source | carbonic anhydrase VA, mitochondrial | 1377 | 0.463 | 0.1897 | No |
| 6 | 2900 | NA | GRIK4 Entrez, Source | glutamate receptor, ionotropic, kainate 4 | 1987 | 0.368 | 0.1853 | No |
| 7 | 2554 | NA | GABRA1 Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, alpha 1 | 2111 | 0.352 | 0.2021 | No |
| 8 | 6326 | NA | SCN2A Entrez, Source | sodium channel, voltage gated, type II alpha subunit | 3344 | 0.228 | 0.1604 | No |
| 9 | 2893 | NA | GRIA4 Entrez, Source | glutamate receptor, ionotropic, AMPA 4 | 3665 | 0.205 | 0.1589 | No |
| 10 | 2898 | NA | GRIK2 Entrez, Source | glutamate receptor, ionotropic, kainate 2 | 4025 | 0.183 | 0.1541 | No |
| 11 | 771 | NA | CA12 Entrez, Source | carbonic anhydrase XII | 4548 | 0.152 | 0.1400 | No |
| 12 | 6331 | NA | SCN5A Entrez, Source | sodium channel, voltage gated, type V alpha subunit | 5010 | 0.132 | 0.1274 | No |
| 13 | 11280 | NA | SCN11A Entrez, Source | sodium channel, voltage gated, type XI alpha subunit | 5980 | 0.096 | 0.0893 | No |
| 14 | 768 | NA | CA9 Entrez, Source | carbonic anhydrase IX | 7017 | 0.064 | 0.0462 | No |
| 15 | 55879 | NA | GABRQ Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, theta | 8389 | 0.036 | -0.0140 | No |
| 16 | 2897 | NA | GRIK1 Entrez, Source | glutamate receptor, ionotropic, kainate 1 | 8981 | 0.026 | -0.0393 | No |
| 17 | 2557 | NA | GABRA4 Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, alpha 4 | 9031 | 0.025 | -0.0399 | No |
| 18 | 2559 | NA | GABRA6 Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, alpha 6 | 9079 | 0.024 | -0.0405 | No |
| 19 | 2564 | NA | GABRE Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, epsilon | 9371 | 0.020 | -0.0526 | No |
| 20 | 2565 | NA | GABRG1 Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, gamma 1 | 10176 | 0.008 | -0.0887 | No |
| 21 | 6335 | NA | SCN9A Entrez, Source | sodium channel, voltage gated, type IX alpha subunit | 10819 | -0.001 | -0.1179 | No |
| 22 | 2555 | NA | GABRA2 Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, alpha 2 | 11072 | -0.004 | -0.1291 | No |
| 23 | 6328 | NA | SCN3A Entrez, Source | sodium channel, voltage gated, type III alpha subunit | 11415 | -0.009 | -0.1441 | No |
| 24 | 759 | NA | CA1 Entrez, Source | carbonic anhydrase I | 11446 | -0.010 | -0.1448 | No |
| 25 | 11238 | NA | CA5B Entrez, Source | carbonic anhydrase VB, mitochondrial | 11656 | -0.013 | -0.1535 | No |
| 26 | 2561 | NA | GABRB2 Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, beta 2 | 12123 | -0.021 | -0.1734 | No |
| 27 | 2891 | NA | GRIA2 Entrez, Source | glutamate receptor, ionotropic, AMPA 2 | 12537 | -0.028 | -0.1904 | No |
| 28 | 6329 | NA | SCN4A Entrez, Source | sodium channel, voltage gated, type IV alpha subunit | 14128 | -0.062 | -0.2589 | No |
| 29 | 765 | NA | CA6 Entrez, Source | carbonic anhydrase VI | 14616 | -0.073 | -0.2764 | No |
| 30 | 6336 | NA | SCN10A Entrez, Source | sodium channel, voltage gated, type X alpha subunit | 15607 | -0.099 | -0.3152 | No |
| 31 | 766 | NA | CA7 Entrez, Source | carbonic anhydrase VII | 15667 | -0.101 | -0.3115 | No |
| 32 | 6332 | NA | SCN7A Entrez, Source | sodium channel, voltage gated, type VII alpha subunit | 15921 | -0.109 | -0.3161 | No |
| 33 | 2890 | NA | GRIA1 Entrez, Source | glutamate receptor, ionotropic, AMPA 1 | 15940 | -0.109 | -0.3100 | No |
| 34 | 377677 | NA | CA13 Entrez, Source | carbonic anhydrase XIII | 15985 | -0.110 | -0.3050 | No |
| 35 | 2892 | NA | GRIA3 Entrez, Source | glutamate receptor, ionotropic, AMPA 3 | 16285 | -0.120 | -0.3110 | No |
| 36 | 361 | NA | AQP4 Entrez, Source | aquaporin 4 | 16941 | -0.142 | -0.3318 | No |
| 37 | 2563 | NA | GABRD Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, delta | 18447 | -0.215 | -0.3868 | No |
| 38 | 2560 | NA | GABRB1 Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, beta 1 | 19578 | -0.301 | -0.4191 | Yes |
| 39 | 770 | NA | CA11 Entrez, Source | carbonic anhydrase XI | 19818 | -0.326 | -0.4093 | Yes |
| 40 | 2566 | NA | GABRG2 Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, gamma 2 | 19891 | -0.334 | -0.3914 | Yes |
| 41 | 2567 | NA | GABRG3 Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, gamma 3 | 20097 | -0.358 | -0.3780 | Yes |
| 42 | 2558 | NA | GABRA5 Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, alpha 5 | 20223 | -0.374 | -0.3600 | Yes |
| 43 | 762 | NA | CA4 Entrez, Source | carbonic anhydrase IV | 21365 | -0.651 | -0.3706 | Yes |
| 44 | 2568 | NA | GABRP Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, pi | 21643 | -0.870 | -0.3280 | Yes |
| 45 | 2901 | NA | GRIK5 Entrez, Source | glutamate receptor, ionotropic, kainate 5 | 21674 | -0.910 | -0.2716 | Yes |
| 46 | 6334 | NA | SCN8A Entrez, Source | sodium channel, voltage gated, type VIII alpha subunit | 21853 | -1.273 | -0.1988 | Yes |
| 47 | 760 | NA | CA2 Entrez, Source | carbonic anhydrase II | 21920 | -1.561 | -0.1026 | Yes |
| 48 | 2899 | NA | GRIK3 Entrez, Source | glutamate receptor, ionotropic, kainate 3 | 21937 | -1.672 | 0.0028 | Yes |
