Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | GE_agg.GE_agg.cls#LTED_versus_MCF7p.GE_agg.cls#LTED_versus_MCF7p_repos |
| Phenotype | GE_agg.cls#LTED_versus_MCF7p_repos |
| Upregulated in class | LTED |
| GeneSet | THIORIDAZINE |
| Enrichment Score (ES) | 0.4515067 |
| Normalized Enrichment Score (NES) | 1.2685386 |
| Nominal p-value | 0.14779271 |
| FDR q-value | 1.0 |
| FWER p-Value | 1.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | 3358 | NA | HTR2C Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled | 136 | 1.570 | 0.1242 | Yes |
| 2 | 2099 | NA | ESR1 Entrez, Source | estrogen receptor 1 | 602 | 0.736 | 0.1641 | Yes |
| 3 | 3363 | NA | HTR7 Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled | 748 | 0.652 | 0.2116 | Yes |
| 4 | 1815 | NA | DRD4 Entrez, Source | dopamine receptor D4 | 912 | 0.580 | 0.2523 | Yes |
| 5 | 150 | NA | ADRA2A Entrez, Source | adrenoceptor alpha 2A | 935 | 0.575 | 0.2991 | Yes |
| 6 | 1544 | NA | CYP1A2 Entrez, Source | cytochrome P450, family 1, subfamily A, polypeptide 2 | 1159 | 0.511 | 0.3313 | Yes |
| 7 | 1128 | NA | CHRM1 Entrez, Source | cholinergic receptor, muscarinic 1 | 1231 | 0.495 | 0.3692 | Yes |
| 8 | 1814 | NA | DRD3 Entrez, Source | dopamine receptor D3 | 1426 | 0.453 | 0.3979 | Yes |
| 9 | 146 | NA | ADRA1D Entrez, Source | adrenoceptor alpha 1D | 1431 | 0.451 | 0.4352 | Yes |
| 10 | 3350 | NA | HTR1A Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled | 2194 | 0.344 | 0.4291 | Yes |
| 11 | 3757 | NA | KCNH2 Entrez, Source | potassium channel, voltage gated eag related subfamily H, member 2 | 2639 | 0.291 | 0.4330 | Yes |
| 12 | 1812 | NA | DRD1 Entrez, Source | dopamine receptor D1 | 3023 | 0.255 | 0.4368 | Yes |
| 13 | 5467 | NA | PPARD Entrez, Source | peroxisome proliferator-activated receptor delta | 3147 | 0.245 | 0.4515 | Yes |
| 14 | 5292 | NA | PIM1 Entrez, Source | Pim-1 proto-oncogene, serine/threonine kinase | 3973 | 0.186 | 0.4293 | No |
| 15 | 1131 | NA | CHRM3 Entrez, Source | cholinergic receptor, muscarinic 3 | 4416 | 0.159 | 0.4224 | No |
| 16 | 3269 | NA | HRH1 Entrez, Source | histamine receptor H1 | 4437 | 0.158 | 0.4347 | No |
| 17 | 6532 | NA | SLC6A4 Entrez, Source | solute carrier family 6 (neurotransmitter transporter), member 4 | 6572 | 0.077 | 0.3439 | No |
| 18 | 10919 | NA | EHMT2 Entrez, Source | euchromatic histone-lysine N-methyltransferase 2 | 6620 | 0.076 | 0.3480 | No |
| 19 | 1129 | NA | CHRM2 Entrez, Source | cholinergic receptor, muscarinic 2 | 6710 | 0.073 | 0.3500 | No |
| 20 | 152 | NA | ADRA2C Entrez, Source | adrenoceptor alpha 2C | 6764 | 0.071 | 0.3535 | No |
| 21 | 2534 | NA | FYN Entrez, Source | FYN proto-oncogene, Src family tyrosine kinase | 7000 | 0.064 | 0.3482 | No |
| 22 | 10951 | NA | CBX1 Entrez, Source | chromobox homolog 1 | 7130 | 0.061 | 0.3474 | No |
| 23 | 1565 | NA | CYP2D6 Entrez, Source | cytochrome P450, family 2, subfamily D, polypeptide 6 | 9172 | 0.023 | 0.2563 | No |
| 24 | 1813 | NA | DRD2 Entrez, Source | dopamine receptor D2 | 9209 | 0.022 | 0.2565 | No |
| 25 | 6311 | NA | ATXN2 Entrez, Source | ataxin 2 | 9743 | 0.014 | 0.2334 | No |
| 26 | 1133 | NA | CHRM5 Entrez, Source | cholinergic receptor, muscarinic 5 | 10564 | 0.003 | 0.1963 | No |
| 27 | 1557 | NA | CYP2C19 Entrez, Source | cytochrome P450, family 2, subfamily C, polypeptide 19 | 11076 | -0.004 | 0.1734 | No |
| 28 | 6530 | NA | SLC6A2 Entrez, Source | solute carrier family 6 (neurotransmitter transporter), member 2 | 11224 | -0.007 | 0.1672 | No |
| 29 | 4986 | NA | OPRK1 Entrez, Source | opioid receptor, kappa 1 | 11408 | -0.009 | 0.1597 | No |
| 30 | 55775 | NA | TDP1 Entrez, Source | tyrosyl-DNA phosphodiesterase 1 | 13012 | -0.038 | 0.0898 | No |
| 31 | 10280 | NA | SIGMAR1 Entrez, Source | sigma non-opioid intracellular receptor 1 | 14929 | -0.081 | 0.0093 | No |
| 32 | 3274 | NA | HRH2 Entrez, Source | histamine receptor H2 | 17234 | -0.153 | -0.0830 | No |
| 33 | 6531 | NA | SLC6A3 Entrez, Source | solute carrier family 6 (neurotransmitter transporter), member 3 | 17717 | -0.176 | -0.0903 | No |
| 34 | 1132 | NA | CHRM4 Entrez, Source | cholinergic receptor, muscarinic 4 | 18528 | -0.219 | -0.1090 | No |
| 35 | 1956 | NA | EGFR Entrez, Source | epidermal growth factor receptor | 18679 | -0.229 | -0.0968 | No |
| 36 | 151 | NA | ADRA2B Entrez, Source | adrenoceptor alpha 2B | 18865 | -0.241 | -0.0852 | No |
| 37 | 3357 | NA | HTR2B Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled | 19513 | -0.294 | -0.0903 | No |
| 38 | 3356 | NA | HTR2A Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled | 19605 | -0.304 | -0.0693 | No |
| 39 | 3362 | NA | HTR6 Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled | 21682 | -0.922 | -0.0872 | No |
| 40 | 5468 | NA | PPARG Entrez, Source | peroxisome proliferator-activated receptor gamma | 21841 | -1.224 | 0.0072 | No |
