Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | GE_agg.GE_agg.cls#LTED_versus_MCF7p.GE_agg.cls#LTED_versus_MCF7p_repos |
| Phenotype | GE_agg.cls#LTED_versus_MCF7p_repos |
| Upregulated in class | LTED |
| GeneSet | CHLORPROMAZINE |
| Enrichment Score (ES) | 0.49760956 |
| Normalized Enrichment Score (NES) | 1.4688939 |
| Nominal p-value | 0.02173913 |
| FDR q-value | 1.0 |
| FWER p-Value | 0.998 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | 3358 | NA | HTR2C Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled | 136 | 1.570 | 0.1092 | Yes |
| 2 | 316 | NA | AOX1 Entrez, Source | aldehyde oxidase 1 | 285 | 1.079 | 0.1818 | Yes |
| 3 | 1816 | NA | DRD5 Entrez, Source | dopamine receptor D5 | 583 | 0.750 | 0.2235 | Yes |
| 4 | 3363 | NA | HTR7 Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled | 748 | 0.652 | 0.2640 | Yes |
| 5 | 1815 | NA | DRD4 Entrez, Source | dopamine receptor D4 | 912 | 0.580 | 0.2992 | Yes |
| 6 | 150 | NA | ADRA2A Entrez, Source | adrenoceptor alpha 2A | 935 | 0.575 | 0.3404 | Yes |
| 7 | 1544 | NA | CYP1A2 Entrez, Source | cytochrome P450, family 1, subfamily A, polypeptide 2 | 1159 | 0.511 | 0.3678 | Yes |
| 8 | 1128 | NA | CHRM1 Entrez, Source | cholinergic receptor, muscarinic 1 | 1231 | 0.495 | 0.4010 | Yes |
| 9 | 1814 | NA | DRD3 Entrez, Source | dopamine receptor D3 | 1426 | 0.453 | 0.4254 | Yes |
| 10 | 146 | NA | ADRA1D Entrez, Source | adrenoceptor alpha 1D | 1431 | 0.451 | 0.4584 | Yes |
| 11 | 7066 | NA | THPO Entrez, Source | thrombopoietin | 2144 | 0.349 | 0.4517 | Yes |
| 12 | 3350 | NA | HTR1A Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled | 2194 | 0.344 | 0.4747 | Yes |
| 13 | 3757 | NA | KCNH2 Entrez, Source | potassium channel, voltage gated eag related subfamily H, member 2 | 2639 | 0.291 | 0.4759 | Yes |
| 14 | 1812 | NA | DRD1 Entrez, Source | dopamine receptor D1 | 3023 | 0.255 | 0.4772 | Yes |
| 15 | 4985 | NA | OPRD1 Entrez, Source | opioid receptor, delta 1 | 3107 | 0.248 | 0.4917 | Yes |
| 16 | 2064 | NA | ERBB2 Entrez, Source | erb-b2 receptor tyrosine kinase 2 | 3345 | 0.228 | 0.4976 | Yes |
| 17 | 1131 | NA | CHRM3 Entrez, Source | cholinergic receptor, muscarinic 3 | 4416 | 0.159 | 0.4606 | No |
| 18 | 3269 | NA | HRH1 Entrez, Source | histamine receptor H1 | 4437 | 0.158 | 0.4713 | No |
| 19 | 4160 | NA | MC4R Entrez, Source | melanocortin 4 receptor | 5133 | 0.126 | 0.4489 | No |
| 20 | 7157 | NA | TP53 Entrez, Source | tumor protein p53 | 5673 | 0.106 | 0.4321 | No |
| 21 | 6532 | NA | SLC6A4 Entrez, Source | solute carrier family 6 (neurotransmitter transporter), member 4 | 6572 | 0.077 | 0.3969 | No |
| 22 | 1129 | NA | CHRM2 Entrez, Source | cholinergic receptor, muscarinic 2 | 6710 | 0.073 | 0.3960 | No |
| 23 | 152 | NA | ADRA2C Entrez, Source | adrenoceptor alpha 2C | 6764 | 0.071 | 0.3988 | No |
| 24 | 2534 | NA | FYN Entrez, Source | FYN proto-oncogene, Src family tyrosine kinase | 7000 | 0.064 | 0.3929 | No |
| 25 | 4137 | NA | MAPT Entrez, Source | microtubule-associated protein tau | 7674 | 0.049 | 0.3658 | No |
| 26 | 1565 | NA | CYP2D6 Entrez, Source | cytochrome P450, family 2, subfamily D, polypeptide 6 | 9172 | 0.023 | 0.2993 | No |
| 27 | 1813 | NA | DRD2 Entrez, Source | dopamine receptor D2 | 9209 | 0.022 | 0.2993 | No |
| 28 | 1559 | NA | CYP2C9 Entrez, Source | cytochrome P450, family 2, subfamily C, polypeptide 9 | 9513 | 0.017 | 0.2868 | No |
| 29 | 1133 | NA | CHRM5 Entrez, Source | cholinergic receptor, muscarinic 5 | 10564 | 0.003 | 0.2391 | No |
| 30 | 6530 | NA | SLC6A2 Entrez, Source | solute carrier family 6 (neurotransmitter transporter), member 2 | 11224 | -0.007 | 0.2096 | No |
| 31 | 4161 | NA | MC5R Entrez, Source | melanocortin 5 receptor | 11236 | -0.007 | 0.2096 | No |
| 32 | 4986 | NA | OPRK1 Entrez, Source | opioid receptor, kappa 1 | 11408 | -0.009 | 0.2025 | No |
| 33 | 4988 | NA | OPRM1 Entrez, Source | opioid receptor, mu 1 | 11537 | -0.011 | 0.1975 | No |
| 34 | 6580 | NA | SLC22A1 Entrez, Source | solute carrier family 22 (organic cation transporter), member 1 | 12847 | -0.035 | 0.1404 | No |
| 35 | 55775 | NA | TDP1 Entrez, Source | tyrosyl-DNA phosphodiesterase 1 | 13012 | -0.038 | 0.1357 | No |
| 36 | 6865 | NA | TACR2 Entrez, Source | tachykinin receptor 2 | 13513 | -0.048 | 0.1164 | No |
| 37 | 9971 | NA | NR1H4 Entrez, Source | nuclear receptor subfamily 1, group H, member 4 | 14056 | -0.060 | 0.0962 | No |
| 38 | 10280 | NA | SIGMAR1 Entrez, Source | sigma non-opioid intracellular receptor 1 | 14929 | -0.081 | 0.0624 | No |
| 39 | 4159 | NA | MC3R Entrez, Source | melanocortin 3 receptor | 15860 | -0.107 | 0.0279 | No |
| 40 | 3274 | NA | HRH2 Entrez, Source | histamine receptor H2 | 17234 | -0.153 | -0.0234 | No |
| 41 | 801 | NA | CALM1 Entrez, Source | calmodulin 1 (phosphorylase kinase, delta) | 17354 | -0.159 | -0.0172 | No |
| 42 | 6531 | NA | SLC6A3 Entrez, Source | solute carrier family 6 (neurotransmitter transporter), member 3 | 17717 | -0.176 | -0.0208 | No |
| 43 | 1132 | NA | CHRM4 Entrez, Source | cholinergic receptor, muscarinic 4 | 18528 | -0.219 | -0.0415 | No |
| 44 | 1956 | NA | EGFR Entrez, Source | epidermal growth factor receptor | 18679 | -0.229 | -0.0315 | No |
| 45 | 151 | NA | ADRA2B Entrez, Source | adrenoceptor alpha 2B | 18865 | -0.241 | -0.0222 | No |
| 46 | 3357 | NA | HTR2B Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled | 19513 | -0.294 | -0.0301 | No |
| 47 | 3356 | NA | HTR2A Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled | 19605 | -0.304 | -0.0119 | No |
| 48 | 3417 | NA | IDH1 Entrez, Source | isocitrate dehydrogenase 1 (NADP+), soluble | 19917 | -0.337 | -0.0014 | No |
| 49 | 1576 | NA | CYP3A4 Entrez, Source | cytochrome P450, family 3, subfamily A, polypeptide 4 | 20305 | -0.385 | 0.0093 | No |
| 50 | 3362 | NA | HTR6 Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled | 21682 | -0.922 | 0.0144 | No |
