Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | GE_agg.GE_agg.cls#LTED_versus_MCF7p.GE_agg.cls#LTED_versus_MCF7p_repos |
| Phenotype | GE_agg.cls#LTED_versus_MCF7p_repos |
| Upregulated in class | LTED |
| GeneSet | AMOXAPINE |
| Enrichment Score (ES) | 0.50870234 |
| Normalized Enrichment Score (NES) | 1.3618902 |
| Nominal p-value | 0.08483755 |
| FDR q-value | 1.0 |
| FWER p-Value | 1.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | 3358 | NA | HTR2C Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled | 136 | 1.570 | 0.1203 | Yes |
| 2 | 1816 | NA | DRD5 Entrez, Source | dopamine receptor D5 | 583 | 0.750 | 0.1605 | Yes |
| 3 | 2099 | NA | ESR1 Entrez, Source | estrogen receptor 1 | 602 | 0.736 | 0.2190 | Yes |
| 4 | 3363 | NA | HTR7 Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled | 748 | 0.652 | 0.2649 | Yes |
| 5 | 1815 | NA | DRD4 Entrez, Source | dopamine receptor D4 | 912 | 0.580 | 0.3043 | Yes |
| 6 | 150 | NA | ADRA2A Entrez, Source | adrenoceptor alpha 2A | 935 | 0.575 | 0.3496 | Yes |
| 7 | 1544 | NA | CYP1A2 Entrez, Source | cytochrome P450, family 1, subfamily A, polypeptide 2 | 1159 | 0.511 | 0.3806 | Yes |
| 8 | 1128 | NA | CHRM1 Entrez, Source | cholinergic receptor, muscarinic 1 | 1231 | 0.495 | 0.4173 | Yes |
| 9 | 1814 | NA | DRD3 Entrez, Source | dopamine receptor D3 | 1426 | 0.453 | 0.4449 | Yes |
| 10 | 146 | NA | ADRA1D Entrez, Source | adrenoceptor alpha 1D | 1431 | 0.451 | 0.4811 | Yes |
| 11 | 7066 | NA | THPO Entrez, Source | thrombopoietin | 2144 | 0.349 | 0.4768 | Yes |
| 12 | 3350 | NA | HTR1A Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled | 2194 | 0.344 | 0.5023 | Yes |
| 13 | 3757 | NA | KCNH2 Entrez, Source | potassium channel, voltage gated eag related subfamily H, member 2 | 2639 | 0.291 | 0.5056 | Yes |
| 14 | 1812 | NA | DRD1 Entrez, Source | dopamine receptor D1 | 3023 | 0.255 | 0.5087 | Yes |
| 15 | 7421 | NA | VDR Entrez, Source | vitamin D (1,25- dihydroxyvitamin D3) receptor | 3726 | 0.201 | 0.4930 | No |
| 16 | 1131 | NA | CHRM3 Entrez, Source | cholinergic receptor, muscarinic 3 | 4416 | 0.159 | 0.4744 | No |
| 17 | 3269 | NA | HRH1 Entrez, Source | histamine receptor H1 | 4437 | 0.158 | 0.4863 | No |
| 18 | 7157 | NA | TP53 Entrez, Source | tumor protein p53 | 5673 | 0.106 | 0.4386 | No |
| 19 | 6532 | NA | SLC6A4 Entrez, Source | solute carrier family 6 (neurotransmitter transporter), member 4 | 6572 | 0.077 | 0.4039 | No |
| 20 | 1129 | NA | CHRM2 Entrez, Source | cholinergic receptor, muscarinic 2 | 6710 | 0.073 | 0.4036 | No |
| 21 | 152 | NA | ADRA2C Entrez, Source | adrenoceptor alpha 2C | 6764 | 0.071 | 0.4069 | No |
| 22 | 1565 | NA | CYP2D6 Entrez, Source | cytochrome P450, family 2, subfamily D, polypeptide 6 | 9172 | 0.023 | 0.2992 | No |
| 23 | 1813 | NA | DRD2 Entrez, Source | dopamine receptor D2 | 9209 | 0.022 | 0.2993 | No |
| 24 | 3064 | NA | HTT Entrez, Source | huntingtin | 10184 | 0.008 | 0.2556 | No |
| 25 | 1133 | NA | CHRM5 Entrez, Source | cholinergic receptor, muscarinic 5 | 10564 | 0.003 | 0.2386 | No |
| 26 | 6530 | NA | SLC6A2 Entrez, Source | solute carrier family 6 (neurotransmitter transporter), member 2 | 11224 | -0.007 | 0.2091 | No |
| 27 | 55775 | NA | TDP1 Entrez, Source | tyrosyl-DNA phosphodiesterase 1 | 13012 | -0.038 | 0.1308 | No |
| 28 | 1588 | NA | CYP19A1 Entrez, Source | cytochrome P450, family 19, subfamily A, polypeptide 1 | 15107 | -0.086 | 0.0424 | No |
| 29 | 1132 | NA | CHRM4 Entrez, Source | cholinergic receptor, muscarinic 4 | 18528 | -0.219 | -0.0957 | No |
| 30 | 151 | NA | ADRA2B Entrez, Source | adrenoceptor alpha 2B | 18865 | -0.241 | -0.0915 | No |
| 31 | 3357 | NA | HTR2B Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled | 19513 | -0.294 | -0.0973 | No |
| 32 | 3356 | NA | HTR2A Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled | 19605 | -0.304 | -0.0770 | No |
| 33 | 2908 | NA | NR3C1 Entrez, Source | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 21034 | -0.516 | -0.1004 | No |
| 34 | 5243 | NA | ABCB1 Entrez, Source | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | 21640 | -0.868 | -0.0580 | No |
| 35 | 3362 | NA | HTR6 Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled | 21682 | -0.922 | 0.0144 | No |
