Fig 1: Enrichment plot: GGTGAAG,MIR-412
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | GE_agg.GE_agg.cls#LTED_versus_MCF7p.GE_agg.cls#LTED_versus_MCF7p_repos |
| Phenotype | GE_agg.cls#LTED_versus_MCF7p_repos |
| Upregulated in class | LTED |
| GeneSet | GGTGAAG,MIR-412 |
| Enrichment Score (ES) | 0.39758992 |
| Normalized Enrichment Score (NES) | 1.1793661 |
| Nominal p-value | 0.20110701 |
| FDR q-value | 0.9621222 |
| FWER p-Value | 1.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | 6304 | NA | SATB1 Entrez, Source | SATB homeobox 1 | 2 | 3.182 | 0.2305 | Yes |
| 2 | 55553 | NA | SOX6 Entrez, Source | SRY (sex determining region Y)-box 6 | 43 | 2.153 | 0.3848 | Yes |
| 3 | 9123 | NA | SLC16A3 Entrez, Source | solute carrier family 16 (monocarboxylate transporter), member 3 | 775 | 0.637 | 0.3976 | Yes |
| 4 | 57716 | NA | PRX Entrez, Source | periaxin | 1797 | 0.392 | 0.3795 | No |
| 5 | 283234 | NA | CCDC88B Entrez, Source | coiled-coil domain containing 88B | 2043 | 0.361 | 0.3945 | No |
| 6 | 388591 | NA | RNF207 Entrez, Source | ring finger protein 207 | 3088 | 0.249 | 0.3650 | No |
| 7 | 3184 | NA | HNRNPD Entrez, Source | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 3461 | 0.219 | 0.3639 | No |
| 8 | 10352 | NA | WARS2 Entrez, Source | tryptophanyl tRNA synthetase 2, mitochondrial | 3786 | 0.197 | 0.3634 | No |
| 9 | 91782 | NA | CHMP7 Entrez, Source | charged multivesicular body protein 7 | 3867 | 0.192 | 0.3737 | No |
| 10 | 1605 | NA | DAG1 Entrez, Source | dystroglycan 1 (dystrophin-associated glycoprotein 1) | 4051 | 0.181 | 0.3784 | No |
| 11 | 23038 | NA | WDTC1 Entrez, Source | WD and tetratricopeptide repeats 1 | 4310 | 0.165 | 0.3786 | No |
| 12 | 23096 | NA | IQSEC2 Entrez, Source | IQ motif and Sec7 domain 2 | 4560 | 0.151 | 0.3782 | No |
| 13 | 2309 | NA | FOXO3 Entrez, Source | forkhead box O3 | 5008 | 0.132 | 0.3674 | No |
| 14 | 8452 | NA | CUL3 Entrez, Source | cullin 3 | 5160 | 0.125 | 0.3696 | No |
| 15 | 8851 | NA | CDK5R1 Entrez, Source | cyclin-dependent kinase 5, regulatory subunit 1 (p35) | 6691 | 0.073 | 0.3052 | No |
| 16 | 672 | NA | BRCA1 Entrez, Source | breast cancer 1, early onset | 6801 | 0.070 | 0.3053 | No |
| 17 | 28511 | NA | NKIRAS2 Entrez, Source | NFKB inhibitor interacting Ras-like 2 | 7096 | 0.061 | 0.2963 | No |
| 18 | 25852 | NA | ARMC8 Entrez, Source | armadillo repeat containing 8 | 8033 | 0.042 | 0.2567 | No |
| 19 | 162466 | NA | PHOSPHO1 Entrez, Source | phosphatase, orphan 1 | 8112 | 0.041 | 0.2561 | No |
| 20 | 1209 | NA | CLPTM1 Entrez, Source | cleft lip and palate associated transmembrane protein 1 | 8526 | 0.033 | 0.2397 | No |
| 21 | 8502 | NA | PKP4 Entrez, Source | plakophilin 4 | 8587 | 0.032 | 0.2392 | No |
| 22 | 79843 | NA | FAM124B Entrez, Source | family with sequence similarity 124B | 8866 | 0.027 | 0.2285 | No |
| 23 | 23196 | NA | FAM120A Entrez, Source | family with sequence similarity 120A | 9328 | 0.020 | 0.2090 | No |
| 24 | 8945 | NA | BTRC Entrez, Source | beta-transducin repeat containing E3 ubiquitin protein ligase | 9423 | 0.019 | 0.2061 | No |
| 25 | 1663 | NA | DDX11 Entrez, Source | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 | 9838 | 0.013 | 0.1881 | No |
| 26 | 51585 | NA | PCF11 Entrez, Source | PCF11 cleavage and polyadenylation factor subunit | 10127 | 0.009 | 0.1757 | No |
| 27 | 9649 | NA | RALGPS1 Entrez, Source | Ral GEF with PH domain and SH3 binding motif 1 | 10538 | 0.003 | 0.1572 | No |
| 28 | 60487 | NA | TRMT11 Entrez, Source | tRNA methyltransferase 11 homolog (S. cerevisiae) | 10976 | -0.003 | 0.1375 | No |
| 29 | 8720 | NA | MBTPS1 Entrez, Source | membrane-bound transcription factor peptidase, site 1 | 11371 | -0.009 | 0.1201 | No |
| 30 | 1656 | NA | DDX6 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box helicase 6 | 11869 | -0.017 | 0.0987 | No |
| 31 | 84915 | NA | FAM222A Entrez, Source | family with sequence similarity 222, member A | 12068 | -0.020 | 0.0911 | No |
| 32 | 91748 | NA | ELMSAN1 Entrez, Source | ELM2 and Myb/SANT-like domain containing 1 | 12108 | -0.021 | 0.0908 | No |
| 33 | 7812 | NA | CSDE1 Entrez, Source | cold shock domain containing E1, RNA-binding | 12163 | -0.021 | 0.0899 | No |
| 34 | 9364 | NA | RAB28 Entrez, Source | RAB28, member RAS oncogene family | 13034 | -0.038 | 0.0531 | No |
| 35 | 57570 | NA | TRMT5 Entrez, Source | tRNA methyltransferase 5 | 13326 | -0.044 | 0.0430 | No |
| 36 | 10395 | NA | DLC1 Entrez, Source | DLC1 Rho GTPase activating protein | 13539 | -0.049 | 0.0369 | No |
| 37 | 1045 | NA | CDX2 Entrez, Source | caudal type homeobox 2 | 14179 | -0.063 | 0.0123 | No |
| 38 | 1196 | NA | CLK2 Entrez, Source | CDC-like kinase 2 | 14352 | -0.067 | 0.0093 | No |
| 39 | 2280 | NA | FKBP1A Entrez, Source | FK506 binding protein 1A, 12kDa | 14415 | -0.068 | 0.0114 | No |
| 40 | 374977 | NA | MROH7 Entrez, Source | maestro heat-like repeat family member 7 | 14462 | -0.069 | 0.0143 | No |
| 41 | 51347 | NA | TAOK3 Entrez, Source | TAO kinase 3 | 14636 | -0.074 | 0.0118 | No |
| 42 | 5500 | NA | PPP1CB Entrez, Source | protein phosphatase 1, catalytic subunit, beta isozyme | 14791 | -0.078 | 0.0104 | No |
| 43 | 259230 | NA | SGMS1 Entrez, Source | sphingomyelin synthase 1 | 15403 | -0.094 | -0.0107 | No |
| 44 | 604 | NA | BCL6 Entrez, Source | B-cell CLL/lymphoma 6 | 15483 | -0.096 | -0.0073 | No |
| 45 | 7543 | NA | ZFX Entrez, Source | zinc finger protein, X-linked | 15521 | -0.097 | -0.0020 | No |
| 46 | 3257 | NA | HPS1 Entrez, Source | Hermansky-Pudlak syndrome 1 | 15706 | -0.102 | -0.0030 | No |
| 47 | 1977 | NA | EIF4E Entrez, Source | eukaryotic translation initiation factor 4E | 16030 | -0.112 | -0.0096 | No |
| 48 | 92305 | NA | TMEM129 Entrez, Source | transmembrane protein 129, E3 ubiquitin protein ligase | 16255 | -0.119 | -0.0112 | No |
| 49 | 7114 | NA | TMSB4X Entrez, Source | thymosin beta 4, X-linked | 16515 | -0.128 | -0.0137 | No |
| 50 | 7322 | NA | UBE2D2 Entrez, Source | ubiquitin-conjugating enzyme E2D 2 | 16585 | -0.130 | -0.0075 | No |
| 51 | 3091 | NA | HIF1A Entrez, Source | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 16635 | -0.131 | -0.0002 | No |
| 52 | 6734 | NA | SRPR Entrez, Source | signal recognition particle receptor (docking protein) | 17410 | -0.161 | -0.0238 | No |
| 53 | 8927 | NA | BSN Entrez, Source | bassoon presynaptic cytomatrix protein | 17484 | -0.165 | -0.0152 | No |
| 54 | 171586 | NA | ABHD3 Entrez, Source | abhydrolase domain containing 3 | 18388 | -0.211 | -0.0411 | No |
| 55 | 287 | NA | ANK2 Entrez, Source | ankyrin 2, neuronal | 19555 | -0.297 | -0.0727 | No |
| 56 | 57561 | NA | ARRDC3 Entrez, Source | arrestin domain containing 3 | 20483 | -0.409 | -0.0853 | No |
| 57 | 3665 | NA | IRF7 Entrez, Source | interferon regulatory factor 7 | 21244 | -0.585 | -0.0775 | No |
| 58 | 114793 | NA | FMNL2 Entrez, Source | formin-like 2 | 21325 | -0.629 | -0.0356 | No |
| 59 | 1184 | NA | CLCN5 Entrez, Source | chloride channel, voltage-sensitive 5 | 21678 | -0.914 | 0.0146 | No |
