DatasetGE_agg.GE_agg.cls#LTED_versus_MCF7n.GE_agg.cls#LTED_versus_MCF7n_repos
PhenotypeGE_agg.cls#LTED_versus_MCF7n_repos
Upregulated in classMCF7n
GeneSetHALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
Enrichment Score (ES)-0.3002976
Normalized Enrichment Score (NES)-1.0862093
Nominal p-value0.25531915
FDR q-value0.4878996
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
11303NACOL12A1
Entrez,  Source
collagen, type XII, alpha 1162.3890.0408No
22201NAFBN2
Entrez,  Source
fibrillin 21091.5350.0633No
32331NAFMOD
Entrez,  Source
fibromodulin1171.4520.0883No
47049NATGFBR3
Entrez,  Source
transforming growth factor, beta receptor III1331.3880.1117No
54147NAMATN2
Entrez,  Source
matrilin 21761.1830.1304No
61281NACOL3A1
Entrez,  Source
collagen, type III, alpha 13360.8480.1378No
7131578NALRRC15
Entrez,  Source
leucine rich repeat containing 153490.8310.1517No
8355NAFAS
Entrez,  Source
Fas cell surface death receptor4520.7340.1598No
92199NAFBLN2
Entrez,  Source
fibulin 24740.7170.1713No
1025878NAMXRA5
Entrez,  Source
matrix-remodelling associated 54940.7030.1827No
116445NASGCG
Entrez,  Source
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)6720.6060.1851No
129235NAIL32
Entrez,  Source
interleukin 327180.5820.1932No
13290NAANPEP
Entrez,  Source
alanyl (membrane) aminopeptidase8110.5420.1984No
141294NACOL7A1
Entrez,  Source
collagen, type VII, alpha 18320.5340.2068No
151277NACOL1A1
Entrez,  Source
collagen, type I, alpha 18440.5270.2154No
161296NACOL8A2
Entrez,  Source
collagen, type VIII, alpha 28830.5140.2226No
1711167NAFSTL1
Entrez,  Source
follistatin-like 19400.5000.2288No
181284NACOL4A2
Entrez,  Source
collagen, type IV, alpha 211210.4600.2285No
19960NACD44
Entrez,  Source
CD44 molecule (Indian blood group)12830.4270.2286No
207058NATHBS2
Entrez,  Source
thrombospondin 213480.4130.2328No
214015NALOX
Entrez,  Source
lysyl oxidase14350.3990.2358No
2210085NAEDIL3
Entrez,  Source
EGF-like repeats and discoidin I-like domains 314780.3930.2407No
23822NACAPG
Entrez,  Source
capping protein (actin filament), gelsolin-like14980.3890.2466No
24800NACALD1
Entrez,  Source
caldesmon 115650.3780.2501No
25115908NACTHRC1
Entrez,  Source
collagen triple helix repeat containing 115830.3750.2559No
26333NAAPLP1
Entrez,  Source
amyloid beta (A4) precursor-like protein 116150.3710.2609No
2722795NANID2
Entrez,  Source
nidogen 2 (osteonidogen)16270.3690.2668No
283486NAIGFBP3
Entrez,  Source
insulin-like growth factor binding protein 316480.3670.2723No
292191NAFAP
Entrez,  Source
fibroblast activation protein, alpha17240.3580.2751No
303915NALAMC1
Entrez,  Source
laminin, gamma 1 (formerly LAMB2)19050.3330.2726No
317980NATFPI2
Entrez,  Source
tissue factor pathway inhibitor 220220.3170.2728No
3230008NAEFEMP2
Entrez,  Source
EGF containing fibulin-like extracellular matrix protein 221420.3030.2726No
331634NADCN
Entrez,  Source
decorin21690.3000.2767No
346678NASPARC
Entrez,  Source
secreted protein, acidic, cysteine-rich (osteonectin)23080.2850.2753No
351290NACOL5A2
Entrez,  Source
collagen, type V, alpha 224140.2750.2753No
361292NACOL6A2
Entrez,  Source
collagen, type VI, alpha 225110.2660.2755No
377857NASCG2
Entrez,  Source
secretogranin II25970.2570.2761No
385768NAQSOX1
Entrez,  Source
quiescin Q6 sulfhydryl oxidase 127480.2440.2734No
394256NAMGP
Entrez,  Source
matrix Gla protein28250.2380.2741No
407169NATPM2
Entrez,  Source
tropomyosin 2 (beta)30660.2170.2669No
4125890NAABI3BP
Entrez,  Source
ABI family, member 3 (NESH) binding protein31080.2150.2687No
425744NAPTHLH
Entrez,  Source
parathyroid hormone-like hormone34080.1940.2584No
4310631NAPOSTN
Entrez,  Source
periostin, osteoblast specific factor35410.1860.2556No
446444NASGCD
Entrez,  Source
sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)37320.1740.2499No
451462NAVCAN
Entrez,  Source
versican37770.1710.2508No
463956NALGALS1
Entrez,  Source
lectin, galactoside-binding, soluble, 138350.1680.2511No
475054NASERPINE1
Entrez,  Source
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 140380.1570.2446No
482247NAFGF2
Entrez,  Source
fibroblast growth factor 2 (basic)40590.1560.2464No
493487NAIGFBP4
Entrez,  Source
insulin-like growth factor binding protein 441600.1510.2444No
504638NAMYLK
Entrez,  Source
myosin light chain kinase43070.1440.2403No
513485NAIGFBP2
Entrez,  Source
insulin-like growth factor binding protein 2, 36kDa43890.1400.2390No
521307NACOL16A1
Entrez,  Source
collagen, type XVI, alpha 146720.1280.2283No
536382NASDC1
Entrez,  Source
syndecan 146790.1280.2302No
546876NATAGLN
Entrez,  Source
transgelin48040.1230.2267No
557168NATPM1
Entrez,  Source
tropomyosin 1 (alpha)48420.1210.2271No
564853NANOTCH2
Entrez,  Source
notch 249480.1180.2243No
5759NAACTA2
Entrez,  Source
actin, alpha 2, smooth muscle, aorta49700.1170.2254No
585396NAPRRX1
Entrez,  Source
paired related homeobox 152260.1070.2155No
592335NAFN1
Entrez,  Source
fibronectin 153670.1030.2109No
605351NAPLOD1
Entrez,  Source
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 156260.0940.2007No
617040NATGFB1
Entrez,  Source
transforming growth factor, beta 156640.0930.2006No
626591NASNAI2
Entrez,  Source
snail family zinc finger 259400.0850.1895No
6350509NACOL5A3
Entrez,  Source
collagen, type V, alpha 360680.0810.1851No
647412NAVCAM1
Entrez,  Source
vascular cell adhesion molecule 161420.0790.1831No
65871NASERPINH1
Entrez,  Source
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)61470.0790.1843No
6610398NAMYL9
Entrez,  Source
myosin, light chain 9, regulatory65530.0680.1669No
6722943NADKK1
Entrez,  Source
dickkopf WNT signaling pathway inhibitor 167990.0620.1568No
684837NANNMT
Entrez,  Source
nicotinamide N-methyltransferase70630.0560.1457No
695352NAPLOD2
Entrez,  Source
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 271380.0540.1432No
703685NAITGAV
Entrez,  Source
integrin, alpha V71840.0530.1421No
71388NARHOB
Entrez,  Source
ras homolog family member B72050.0520.1421No
721893NAECM1
Entrez,  Source
extracellular matrix protein 175790.0450.1258No
736422NASFRP1
Entrez,  Source
secreted frizzled-related protein 176110.0440.1251No
741314NACOPA
Entrez,  Source
coatomer protein complex, subunit alpha76270.0440.1252No
753624NAINHBA
Entrez,  Source
inhibin, beta A80000.0370.1088No
763908NALAMA2
Entrez,  Source
laminin, alpha 282230.0320.0991No
77966NACD59
Entrez,  Source
CD59 molecule, complement regulatory protein83930.0290.0919No
7810979NAFERMT2
Entrez,  Source
fermitin family member 285110.0270.0870No
794907NANT5E
Entrez,  Source
5'-nucleotidase, ecto (CD73)85490.0260.0858No
801601NADAB2
Entrez,  Source
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)86470.0240.0817No
81633NABGN
Entrez,  Source
biglycan86500.0240.0820No
822006NAELN
Entrez,  Source
elastin90120.0180.0658No
835806NAPTX3
Entrez,  Source
pentraxin 3, long90380.0180.0650No
845999NARGS4
Entrez,  Source
regulator of G-protein signaling 491970.0150.0580No
858038NAADAM12
Entrez,  Source
ADAM metallopeptidase domain 1293050.0130.0533No
867474NAWNT5A
Entrez,  Source
wingless-type MMTV integration site family, member 5A93260.0130.0526No
873569NAIL6
Entrez,  Source
interleukin 693400.0130.0522No
883576NACXCL8
Entrez,  Source
chemokine (C-X-C motif) ligand 893900.0130.0502No
896443NASGCB
Entrez,  Source
sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)94650.0110.0470No
906696NASPP1
Entrez,  Source
secreted phosphoprotein 196110.0090.0405No
9157692NAMAGEE1
Entrez,  Source
melanoma antigen family E, 196210.0090.0403No
924487NAMSX1
Entrez,  Source
msh homeobox 196840.0080.0376No
934314NAMMP3
Entrez,  Source
matrix metallopeptidase 3 (stromelysin 1, progelatinase)96990.0080.0371No
942817NAGPC1
Entrez,  Source
glypican 198170.0070.0318No
956424NASFRP4
Entrez,  Source
secreted frizzled-related protein 499560.0050.0256No
9626577NAPCOLCE2
Entrez,  Source
procollagen C-endopeptidase enhancer 2100570.0040.0211No
979244NACRLF1
Entrez,  Source
cytokine receptor-like factor 1102990.0010.0100No
98627NABDNF
Entrez,  Source
brain-derived neurotrophic factor104100.0000.0050No
997422NAVEGFA
Entrez,  Source
vascular endothelial growth factor A10509-0.0010.0005No
100284217NALAMA1
Entrez,  Source
laminin, alpha 110626-0.002-0.0048No
1013678NAITGA5
Entrez,  Source
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)10864-0.004-0.0156No
1022303NAFOXC2
Entrez,  Source
forkhead box C210909-0.005-0.0175No
1036372NACXCL6
Entrez,  Source
chemokine (C-X-C motif) ligand 611118-0.007-0.0269No
1047052NATGM2
Entrez,  Source
transglutaminase 211443-0.010-0.0416No
1051009NACDH11
Entrez,  Source
cadherin 11, type 2, OB-cadherin (osteoblast)11604-0.012-0.0488No
1061278NACOL1A2
Entrez,  Source
collagen, type I, alpha 211625-0.012-0.0495No
1076695NASPOCK1
Entrez,  Source
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 111673-0.012-0.0514No
1083371NATNC
Entrez,  Source
tenascin C11693-0.013-0.0521No
1091004NACDH6
Entrez,  Source
cadherin 6, type 2, K-cadherin (fetal kidney)11971-0.016-0.0645No
1105270NASERPINE2
Entrez,  Source
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 212006-0.016-0.0658No
1111301NACOL11A1
Entrez,  Source
collagen, type XI, alpha 112222-0.019-0.0753No
1125159NAPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide12311-0.020-0.0790No
1135479NAPPIB
Entrez,  Source
peptidylprolyl isomerase B (cyclophilin B)12369-0.021-0.0813No
1144060NALUM
Entrez,  Source
lumican12409-0.021-0.0827No
1157424NAVEGFC
Entrez,  Source
vascular endothelial growth factor C12973-0.030-0.1080No
1161000NACDH2
Entrez,  Source
cadherin 2, type 1, N-cadherin (neuronal)13054-0.031-0.1111No
1171647NAGADD45A
Entrez,  Source
growth arrest and DNA-damage-inducible, alpha13289-0.035-0.1212No
1183909NALAMA3
Entrez,  Source
laminin, alpha 313827-0.044-0.1451No
11951330NATNFRSF12A
Entrez,  Source
tumor necrosis factor receptor superfamily, member 12A13941-0.046-0.1495No
12026585NAGREM1
Entrez,  Source
gremlin 1, DAN family BMP antagonist14045-0.048-0.1534No
1212200NAFBN1
Entrez,  Source
fibrillin 114071-0.049-0.1537No
122649NABMP1
Entrez,  Source
bone morphogenetic protein 114372-0.054-0.1665No
12310272NAFSTL3
Entrez,  Source
follistatin-like 3 (secreted glycoprotein)14576-0.059-0.1748No
1245217NAPFN2
Entrez,  Source
profilin 214796-0.063-0.1837No
12564175NAP3H1
Entrez,  Source
prolyl 3-hydroxylase 114965-0.067-0.1902No
12679709NACOLGALT1
Entrez,  Source
collagen beta(1-O)galactosyltransferase 115091-0.069-0.1948No
1273688NAITGB1
Entrez,  Source
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)15200-0.072-0.1985No
1283491NACYR61
Entrez,  Source
cysteine-rich, angiogenic inducer, 6115514-0.079-0.2115No
1295654NAHTRA1
Entrez,  Source
HtrA serine peptidase 115692-0.083-0.2181No
13050863NANTM
Entrez,  Source
neurotrimin15794-0.086-0.2213No
1314017NALOXL2
Entrez,  Source
lysyl oxidase-like 216077-0.095-0.2326No
1322919NACXCL1
Entrez,  Source
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)16163-0.097-0.2348No
1334312NAMMP1
Entrez,  Source
matrix metallopeptidase 1 (interstitial collagenase)16283-0.101-0.2385No
1343918NALAMC2
Entrez,  Source
laminin, gamma 216359-0.103-0.2401No
1354313NAMMP2
Entrez,  Source
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)16475-0.106-0.2435No
1362316NAFLNA
Entrez,  Source
filamin A, alpha16698-0.113-0.2517No
1373398NAID2
Entrez,  Source
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein16742-0.115-0.2517No
1386385NASDC4
Entrez,  Source
syndecan 416843-0.119-0.2542No
1395817NAPVR
Entrez,  Source
poliovirus receptor16975-0.123-0.2581No
1401809NADPYSL3
Entrez,  Source
dihydropyrimidinase-like 317361-0.138-0.2734No
1412517NAFUCA1
Entrez,  Source
fucosidase, alpha-L- 1, tissue17378-0.138-0.2717No
1425376NAPMP22
Entrez,  Source
peripheral myelin protein 2217442-0.141-0.2721No
1433725NAJUN
Entrez,  Source
jun proto-oncogene17597-0.147-0.2766No
1445118NAPCOLCE
Entrez,  Source
procollagen C-endopeptidase enhancer17650-0.149-0.2764No
1454176NAMCM7
Entrez,  Source
minichromosome maintenance complex component 717893-0.160-0.2847No
1463600NAIL15
Entrez,  Source
interleukin 1518020-0.165-0.2876No
147813NACALU
Entrez,  Source
calumenin18204-0.175-0.2930No
1486387NACXCL12
Entrez,  Source
chemokine (C-X-C motif) ligand 1218226-0.176-0.2909No
1499353NASLIT2
Entrez,  Source
slit homolog 2 (Drosophila)18288-0.179-0.2906No
1501311NACOMP
Entrez,  Source
cartilage oligomeric matrix protein18350-0.183-0.2902No
1514616NAGADD45B
Entrez,  Source
growth arrest and DNA-damage-inducible, beta18376-0.184-0.2881No
1527171NATPM4
Entrez,  Source
tropomyosin 418384-0.185-0.2852No
153667NADST
Entrez,  Source
dystonin18414-0.186-0.2833No
1541490NACTGF
Entrez,  Source
connective tissue growth factor18535-0.194-0.2855No
1551282NACOL4A1
Entrez,  Source
collagen, type IV, alpha 118668-0.202-0.2880No
1564232NAMEST
Entrez,  Source
mesoderm specific transcript18937-0.221-0.2964Yes
1571842NAECM2
Entrez,  Source
extracellular matrix protein 2, female organ and adipocyte specific18946-0.222-0.2930Yes
1588985NAPLOD3
Entrez,  Source
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 318969-0.224-0.2901Yes
1598076NAMFAP5
Entrez,  Source
microfibrillar associated protein 519059-0.231-0.2901Yes
1602882NAGPX7
Entrez,  Source
glutathione peroxidase 719119-0.236-0.2887Yes
1617057NATHBS1
Entrez,  Source
thrombospondin 119129-0.236-0.2850Yes
1628325NAFZD8
Entrez,  Source
frizzled class receptor 819170-0.239-0.2827Yes
1631289NACOL5A1
Entrez,  Source
collagen, type V, alpha 119354-0.255-0.2867Yes
1646535NASLC6A8
Entrez,  Source
solute carrier family 6 (neurotransmitter transporter), member 819357-0.255-0.2823Yes
1655021NAOXTR
Entrez,  Source
oxytocin receptor19561-0.275-0.2868Yes
1666303NASAT1
Entrez,  Source
spermidine/spermine N1-acetyltransferase 119677-0.288-0.2871Yes
1677076NATIMP1
Entrez,  Source
TIMP metallopeptidase inhibitor 119705-0.292-0.2833Yes
16810409NABASP1
Entrez,  Source
brain abundant, membrane attached signal protein 119779-0.300-0.2814Yes
16910516NAFBLN5
Entrez,  Source
fibulin 519788-0.301-0.2765Yes
1706641NASNTB1
Entrez,  Source
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)19931-0.319-0.2775Yes
1712619NAGAS1
Entrez,  Source
growth arrest-specific 120014-0.329-0.2755Yes
1724035NALRP1
Entrez,  Source
low density lipoprotein receptor-related protein 120186-0.351-0.2773Yes
17310486NACAP2
Entrez,  Source
CAP, adenylate cyclase-associated protein, 2 (yeast)20266-0.360-0.2746Yes
1747070NATHY1
Entrez,  Source
Thy-1 cell surface antigen20396-0.377-0.2740Yes
1752014NAEMP3
Entrez,  Source
epithelial membrane protein 320586-0.403-0.2757Yes
17611010NAGLIPR1
Entrez,  Source
GLI pathogenesis-related 120606-0.407-0.2694Yes
1774323NAMMP14
Entrez,  Source
matrix metallopeptidase 14 (membrane-inserted)20647-0.413-0.2641Yes
1784148NAMATN3
Entrez,  Source
matrilin 320774-0.436-0.2623Yes
1792026NAENO2
Entrez,  Source
enolase 2 (gamma, neuronal)20805-0.442-0.2560Yes
1806586NASLIT3
Entrez,  Source
slit homolog 3 (Drosophila)20832-0.446-0.2494Yes
1818572NAPDLIM4
Entrez,  Source
PDZ and LIM domain 420858-0.452-0.2427Yes
18223705NACADM1
Entrez,  Source
cell adhesion molecule 120927-0.468-0.2377Yes
1832192NAFBLN1
Entrez,  Source
fibulin 120955-0.474-0.2307Yes
1843690NAITGB3
Entrez,  Source
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)21087-0.505-0.2279Yes
1851293NACOL6A3
Entrez,  Source
collagen, type VI, alpha 321223-0.544-0.2246Yes
1867128NATNFAIP3
Entrez,  Source
tumor necrosis factor, alpha-induced protein 321352-0.592-0.2202Yes
1873673NAITGA2
Entrez,  Source
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)21412-0.621-0.2121Yes
1883693NAITGB5
Entrez,  Source
integrin, beta 521442-0.635-0.2024Yes
1895329NAPLAUR
Entrez,  Source
plasminogen activator, urokinase receptor21496-0.659-0.1933Yes
19056937NAPMEPA1
Entrez,  Source
prostate transmembrane protein, androgen induced 121525-0.688-0.1826Yes
1912669NAGEM
Entrez,  Source
GTP binding protein overexpressed in skeletal muscle21607-0.746-0.1734Yes
1922697NAGJA1
Entrez,  Source
gap junction protein, alpha 1, 43kDa21643-0.778-0.1615Yes
1937431NAVIM
Entrez,  Source
vimentin21666-0.796-0.1486Yes
1944016NALOXL1
Entrez,  Source
lysyl oxidase-like 121688-0.820-0.1353Yes
1957456NAWIPF1
Entrez,  Source
WAS/WASL interacting protein family, member 121710-0.844-0.1216Yes
196374NAAREG
Entrez,  Source
amphiregulin21917-1.444-0.1059Yes
1977045NATGFBI
Entrez,  Source
transforming growth factor, beta-induced, 68kDa21931-1.552-0.0795Yes
1984982NATNFRSF11B
Entrez,  Source
tumor necrosis factor receptor superfamily, member 11b21979-2.257-0.0424Yes
1997078NATIMP3
Entrez,  Source
TIMP metallopeptidase inhibitor 321991-2.4870.0004Yes
Table: GSEA details [plain text format]



Fig 2: HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION: Random ES distribution   
Gene set null distribution of ES for HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION