AAstretch launched 20/10/2010 at 0:36:14 alpha 0.05 data_source caenorhabditis_elegans.prot.txt explore 0 flank_length 30 flank_start 0 ignore (predicted|hypothetical|potential|ann\|---) isoform_check on patt_extrem_len 2 patt_gap_max_number 100 patt_gap_min_size 0 patt_stretch_max_size 1000 patt_stretch_min_size 5 residue Q rich_gap_tolerance auto rich_stretch_min_aa_perc 20 rich_stretch_min_size 30 rich_verbose 0 rich_win_length 5 scan 1 scanmode seed seed_gap_max_size 5 seed_seed_max_size 1000 seed_seed_min_size 5 seed_stretch_min_aa_perc 75 sync 1 tuple 1 verbose 0 Global_stat_tup_1 482265 445848 482542 592747 468391 568946 558809 549213 771520 237098 570140 99205 285151 423071 732970 532130 208082 181563 437555 369034 Available sequences 20878 Total AA count 8996280 Total stretches found 259 1st-M 20878 Name Len Stretches_tot Stretch_seq Stretch_len Q% pureQ_len pureQ_ratio start stop Position% lf_seq rf_seq go_func go_proc go_comp omim >prot|M04B2.1|cod|M04B2.1|gene|M04B2.1|ann|mep-1 is required for repression by the fem-3 3' UTR in vivo, and for maintenance of somatic (versus germline) differentiation. MEP-1 protein has zinc-finger domains and a glutamine/asparagine-rich domain. [Source: WormBase] 870 2 QQQQQ 5 100 5 1 545 549 62 IRNIMMPKQDDHLYINRWLWERPQLDPSIL AALQQAQQKKQQQLLHQQQAAQAAAAAQLL GO:0016758:transferase activity, transferring hexosyl groups; --- --- --- >prot|M04B2.1|cod|M04B2.1|gene|M04B2.1|ann|mep-1 is required for repression by the fem-3 3' UTR in vivo, and for maintenance of somatic (versus germline) differentiation. MEP-1 protein has zinc-finger domains and a glutamine/asparagine-rich domain. [Source: WormBase] 870 2 QQLQQQQQQQQ 11 90.9090909090909 8 0.727272727272727 582 592 66 LQQAQQKKQQQLLHQQQAAQAAAAAQLLRK ARLREQQQAAQFRQVAQLLQQQSAQAQRAQ GO:0016758:transferase activity, transferring hexosyl groups; --- --- --- >prot|Y50D4C.5|cod|Y50D4C.5|gene|Y50D4C.5|ann|Y50D4C.5 [Source:RefSeq_peptide;Acc:NP_503361] 530 1 QQQQQLQGQ 9 77.7777777777778 5 0.555555555555556 394 402 74 SVKQEVYEQSSSSNCPSISSTPRSSEDPAN NVVFGAHPEHLNNLWMVSKEIRDQQLQLER --- --- --- --- >prot|Y44E3A.6a|cod|Y44E3A.6a|gene|Y44E3A.6|ann|Y44E3A.6a [Source:RefSeq_peptide;Acc:NP_740827] 841 1 QQQQQ 5 100 5 1 678 682 80 EHFRHGINEYLATTSQMIQGTAMATMQMAA KGELERIALLRMIETNPEEAVEAALNKADM --- --- --- --- >prot|R10E11.1a|cod|R10E11.1a|gene|R10E11.1|ann|cbp-1 encodes a homolog of the mammalian transcriptional cofactors CBP (OMIM:600140) and p300 (E1A-BINDING PROTEIN, 300-KD. OMIM:602700) that have been shown to possess histone acetyltransferase activity, and which, when mutated, lead to Rubinstein-Taybi syndrome (OMIM:180849) and colorectal cancer (OMIM:114500). at least one splicing form of CBP-1 exhibits histone acetyltransferase (HAT) activity in vitro and has a glutamine/asparagine-rich domain. CBP-1 is required during embryogenesis for differentiation of all non-neuronal somatic cell types. CBP-1 is expressed very early in embryogenesis, suggesting that it may interact with maternally provided transcription factors, such as SKN-1, to specific developmental fates. [Source: WormBase] 2045 1 QQQQQQQREQ 10 80 7 0.7 363 372 17 PNGQPGPQAAAAQHAAQQQAAAQAQAQAAA EAAAAAQRNGAGRATTPGSSMLATHQDPEK GO:0005515:protein binding;GO:0004879:ligand-dependent nuclear receptor activity;GO:0003700:sequence-specific DNA binding transcription factor activity;GO:0003707:steroid hormone receptor activity;GO:0008270:zinc ion binding;GO:0043565:sequence-specific DNA binding; GO:0006355:regulation of transcription, DNA-dependent; GO:0005634:nucleus; --- >prot|C04A2.3c.1|cod|C04A2.3c.1|gene|C04A2.3|ann|egl-27 encodes a homolog of human MTA1, part of an ATP-dependent complex with nucleosome remodelling and histone deacetylation activities that may promote tumor metastasis. in conjunction with its paralog egr-1, egl-27 is required for proper organization in all parts of the embryo, and for the embryonic expression of hlh-8. [Source: WormBase] 612 3 QQQQQ 5 100 5 1 386 390 63 QHQMALQQQLEAHQVQLMMAHQHQQKMIAE RHAAAQQLREREQREQRERERERQHQQQAQ GO:0004767:sphingomyelin phosphodiesterase activity; --- GO:0005576:extracellular region; --- >prot|C04A2.3c.1|cod|C04A2.3c.1|gene|C04A2.3|ann|egl-27 encodes a homolog of human MTA1, part of an ATP-dependent complex with nucleosome remodelling and histone deacetylation activities that may promote tumor metastasis. in conjunction with its paralog egr-1, egl-27 is required for proper organization in all parts of the embryo, and for the embryonic expression of hlh-8. [Source: WormBase] 612 3 QQQQQ 5 100 5 1 425 429 69 AQQLREREQREQRERERERQHQQQAQQALH HAAAAANQLNPAMMQMMALMANSAASQQDI GO:0004767:sphingomyelin phosphodiesterase activity; --- GO:0005576:extracellular region; --- >prot|C04A2.3c.1|cod|C04A2.3c.1|gene|C04A2.3|ann|egl-27 encodes a homolog of human MTA1, part of an ATP-dependent complex with nucleosome remodelling and histone deacetylation activities that may promote tumor metastasis. in conjunction with its paralog egr-1, egl-27 is required for proper organization in all parts of the embryo, and for the embryonic expression of hlh-8. [Source: WormBase] 612 3 QQQQQQQQ 8 100 8 1 468 475 76 LNPAMMQMMALMANSAASQQDIARLMEMAA AAQAQAQRDQERERREREAREREAARERER GO:0004767:sphingomyelin phosphodiesterase activity; --- GO:0005576:extracellular region; --- >prot|M01B12.4b|cod|M01B12.4b|gene|M01B12.4|ann|M01B12.4a [Source:RefSeq_peptide;Acc:NP_740823] 644 1 QQQQQQQ 7 100 7 1 491 497 76 APVGAGEGSGVNDLIGVFGNDFINQNQPPP RLVQFDEDTDSGKASPTSSETSSTTDEVTP GO:0005515:protein binding; --- --- --- >prot|H20J18.1a.1|cod|H20J18.1a.1|gene|H20J18.1|ann|scd-1 encodes a novel protein with several regions that are extremely glutamine (Q) rich, interspersed with other residues (usually alanine). SCD-1 affects signalling by proteins in the DAF-7/transforming growth factor (TGF)-beta pathway (DAF-1, DAF-8, and DAF-14), and the Q-rich regions of SCD-1 protein may mediate epigenetic changes of stably heritable tertiary conformation. [Source: WormBase] 947 3 QQQQQQQMQQQLQQQ 15 86.6666666666667 7 0.466666666666667 449 463 47 QQLQGPQGQAQNQMQQQLIQQQLNQILARN ASNNALQQQLQQLVEQQRQQQQQQQQSVQN --- --- --- --- >prot|H20J18.1a.1|cod|H20J18.1a.1|gene|H20J18.1|ann|scd-1 encodes a novel protein with several regions that are extremely glutamine (Q) rich, interspersed with other residues (usually alanine). SCD-1 affects signalling by proteins in the DAF-7/transforming growth factor (TGF)-beta pathway (DAF-1, DAF-8, and DAF-14), and the Q-rich regions of SCD-1 protein may mediate epigenetic changes of stably heritable tertiary conformation. [Source: WormBase] 947 3 QQQLQQLVEQQRQQQQQQQQ 20 75 8 0.4 470 489 49 QLNQILARNQQQQQQQMQQQLQQQASNNAL SVQNAQIAAAATAAASTSTPNSQDRKIPHT --- --- --- --- >prot|H20J18.1a.1|cod|H20J18.1a.1|gene|H20J18.1|ann|scd-1 encodes a novel protein with several regions that are extremely glutamine (Q) rich, interspersed with other residues (usually alanine). SCD-1 affects signalling by proteins in the DAF-7/transforming growth factor (TGF)-beta pathway (DAF-1, DAF-8, and DAF-14), and the Q-rich regions of SCD-1 protein may mediate epigenetic changes of stably heritable tertiary conformation. [Source: WormBase] 947 3 QQQQQ 5 100 5 1 606 610 63 LQHALLQHANNSTNSASKATLHDIRFQAMA VAASGVGQGQTTLHPFIRPNDTTRQAQLVN --- --- --- --- >prot|F23H11.1|cod|F23H11.1|gene|F23H11.1|ann|The bra-2 gene encodes a homolog of the human BMP receptor-associated molecule (BRAM1), paralogous to bra-1, that may act upon the SMA-6 TGF-beta signalling pathway [Source: WormBase] 214 1 QQQQQ 5 100 5 1 14 18 6 MADGQVHDELMMDQQQQQGVVPQQGDIHLS GVVPQQGDIHLSPIDKDLGDAALENNVRQY GO:0003677:DNA binding; GO:0006334:nucleosome assembly; GO:0005634:nucleus; --- >prot|R10E4.2a.3|cod|R10E4.2a.3|gene|R10E4.2|ann|Temporarily Assigned Gene name family member (tag-310) [Source:RefSeq_peptide;Acc:NP_497856] 357 1 QQQQQQQQPQQGQAPQQQQQ 20 80 8 0.4 8 27 2 MNASSAPQQQQQQQQPQQGQAPQQQQQGPP GPPQHQYQQQRPFHGRVQNHMRGSGPFGNS GO:0005230:extracellular ligand-gated ion channel activity; GO:0006811:ion transport; GO:0016021:integral to membrane;GO:0045211:postsynaptic membrane; --- >prot|T05A10.1i|cod|T05A10.1i|gene|T05A10.1|ann|sma-9 encodes, by alternative splicing, at least two large (~2000-residue) protein with at least three N-terminal involucrin domains, seven C-terminal zinc-finger domains, and a glutamine/asparagine-rich domain. SMA-9 is orthologous to human HIVEP1 (OMIM:194540), HIVEP2 (OMIM:143054), and HIVEP3 (OMIM:606649), and to Drosophila SCHNURRI (FBgn0003396). SMA-9 proteins are required for growth to normally large body size. [Source: WormBase] 1927 5 QQQQASQQQQQVQHVQQQQQSQQQQQQ 27 77.7777777777778 6 0.222222222222222 40 66 2 NNFQQVQREQLNHQRLLQAQLQTNGPGSVS VASQQNQPQLQMNAQILQALSTPQGQNLVN --- --- --- --- >prot|T05A10.1i|cod|T05A10.1i|gene|T05A10.1|ann|sma-9 encodes, by alternative splicing, at least two large (~2000-residue) protein with at least three N-terminal involucrin domains, seven C-terminal zinc-finger domains, and a glutamine/asparagine-rich domain. SMA-9 is orthologous to human HIVEP1 (OMIM:194540), HIVEP2 (OMIM:143054), and HIVEP3 (OMIM:606649), and to Drosophila SCHNURRI (FBgn0003396). SMA-9 proteins are required for growth to normally large body size. [Source: WormBase] 1927 5 QQQQQLQQQQAQQ 13 84.6153846153846 5 0.384615384615385 272 284 14 SQAQQQAQQAQHVQSRQMQPSQQSQVQAQL LSQQQAQQQQQLQQLQLQQFLQQQQQLHQQ --- --- --- --- >prot|T05A10.1i|cod|T05A10.1i|gene|T05A10.1|ann|sma-9 encodes, by alternative splicing, at least two large (~2000-residue) protein with at least three N-terminal involucrin domains, seven C-terminal zinc-finger domains, and a glutamine/asparagine-rich domain. SMA-9 is orthologous to human HIVEP1 (OMIM:194540), HIVEP2 (OMIM:143054), and HIVEP3 (OMIM:606649), and to Drosophila SCHNURRI (FBgn0003396). SMA-9 proteins are required for growth to normally large body size. [Source: WormBase] 1927 5 QQQAQQQQQLQQLQLQQ 17 76.4705882352941 5 0.294117647058824 287 303 14 RQMQPSQQSQVQAQLQQQQQLQQQQAQQLS FLQQQQQLHQQRAAAQQAQAQNNASQQRPS --- --- --- --- >prot|T05A10.1i|cod|T05A10.1i|gene|T05A10.1|ann|sma-9 encodes, by alternative splicing, at least two large (~2000-residue) protein with at least three N-terminal involucrin domains, seven C-terminal zinc-finger domains, and a glutamine/asparagine-rich domain. SMA-9 is orthologous to human HIVEP1 (OMIM:194540), HIVEP2 (OMIM:143054), and HIVEP3 (OMIM:606649), and to Drosophila SCHNURRI (FBgn0003396). SMA-9 proteins are required for growth to normally large body size. [Source: WormBase] 1927 5 QQQQQLHQQ 9 77.7777777777778 5 0.555555555555556 306 314 15 QLQQQQAQQLSQQQAQQQQQLQQLQLQQFL RAAAQQAQAQNNASQQRPSVASTPALSSTP --- --- --- --- >prot|T05A10.1i|cod|T05A10.1i|gene|T05A10.1|ann|sma-9 encodes, by alternative splicing, at least two large (~2000-residue) protein with at least three N-terminal involucrin domains, seven C-terminal zinc-finger domains, and a glutamine/asparagine-rich domain. SMA-9 is orthologous to human HIVEP1 (OMIM:194540), HIVEP2 (OMIM:143054), and HIVEP3 (OMIM:606649), and to Drosophila SCHNURRI (FBgn0003396). SMA-9 proteins are required for growth to normally large body size. [Source: WormBase] 1927 5 QQAQQQQQGQSQ 12 75 5 0.416666666666667 383 394 19 MQAQLQQQLLLQQQQAQAQQAQQAQQAQLA NRTVSQALQYIQSMQLQQRADGTPNAPSLS --- --- --- --- >prot|W04B5.3a|cod|W04B5.3a|gene|W04B5.3|ann|W04B5.3b [Source:RefSeq_peptide;Acc:NP_741096] 426 1 QQQQQQ 6 100 6 1 344 349 80 PQPLPQQMSRQQAPIYQNQQQMPPGYNPYL MAATVPMPYPSGAAAVPVSAMAPQVVQYPT --- GO:0007156:homophilic cell adhesion; GO:0016020:membrane; --- >prot|C34D4.14|cod|C34D4.14|gene|C34D4.14|ann|C34D4.14 [Source:RefSeq_peptide;Acc:NP_501120] 2761 1 QQQQQQ 6 100 6 1 1801 1806 65 EPMGGEESDSAASMRSAASSNSQMSMGSSS DSDMTPRDSAGTPSTPRDDKNQTLSVSAPD GO:0005524:ATP binding;GO:0004736:pyruvate carboxylase activity;GO:0009374:biotin binding;GO:0016874:ligase activity; GO:0008152:metabolic process;GO:0006094:gluconeogenesis; GO:0005737:cytoplasm; --- >prot|C07A9.3b|cod|C07A9.3b|gene|C07A9.3|ann|tlk-1 encodes, through alternative splicing, two isoforms of a Tousled-class serine/threonine protein kinase. TLK-1A/B are orthologous to Tousled from A. thaliana. tlk-1(RNAi) embryos have, compared to normal embryos, reduced phosphorylation of the RNA polymerase II C-terminal domain at Serine-2 and methylation of histone H3 at Lysine-36 (posttranslational modifications associated with transcriptional elongation), along with a lethal phenotype consistent with general defects in zygotic transcription. TLK-1A/B have a glutamine/asparagine-rich domain and a putative coil domain. [Source: WormBase] 965 1 QQQQQYQQQQAQ 12 83.3333333333333 5 0.416666666666667 184 195 19 QMQQQQQHHQQQYNMSYHNHQQQMQQMHYH HHQMYAPQIQQQQQQPQQQSQQQSAQQPQQ --- GO:0006470:protein amino acid dephosphorylation; --- --- >prot|F07C6.4b|cod|F07C6.4b|gene|F07C6.4|ann|F07C6.4b [Source:RefSeq_peptide;Acc:NP_502442] 639 1 QQQQQQHQQQ 10 90 6 0.6 615 624 96 ATMGAQSPAPPPNGKLPTNPQMEALLSYYK SRSAPSQQPKTATIV --- --- --- --- >prot|Y59A8B.1a|cod|Y59A8B.1a|gene|Y59A8B.1|ann|dpy-21 encodes a novel, conserved protein with a proline-rich N terminus. dpy-21 affects RNA levels of X-linked dosage-compensated genes, body length in hermaphrodites, and fertility and male tail development in males. DPY-21 interacts in vivo with DPY-27 and SDC-3, members of the dosage compensation complex, and like members of the dosage compensation complex, is diffusely localized in nuclei of XX embryos containing <40 cells, but then specifically localizes to X chromosomes of XX embryos with >40 cells, remaining on the X throughout development. in XO embryos, DPY-21 is dispersed throughout the nucleus in multiple foci that are not coincident with the X chromosome. in hermaphrodites, localization of DPY-21 to the X chromosome requires activity of SDC-2, SDC-3, DPY-26, DPY-27, and DPY-28. DPY-21 is not, however, required reciprocally for the stability or localization of these other dosage compensation proteins. in addition, unlike SDC-3 and other members of the dosage compensation complex, DPY-21 is not recruited to the autosomal her-1 regulatory region, suggesting that DPY-21 is not part of the gene-specific complex that represses her-1 expression in hermaphrodites. [Source: WormBase] 1641 1 QQQQQQ 6 100 6 1 91 96 5 SSSHDNDYSEYRPRRGPKTPPLPPPDEPVK PIVAPYSYYPTYGSSTGYPYPYPTMMMPQQ --- --- --- --- >prot|K06A1.1|cod|K06A1.1|gene|K06A1.1|ann|K06A1.1 encodes an AP-2-like transcription factor. [Source: WormBase] 365 1 QQQQQQ 6 100 6 1 96 101 26 QPPVCGVSTFTYAREFPVSNSQQFFNVTPP GTGGSGEEDYCIPKSEDRDHSSNYSQVATK GO:0008270:zinc ion binding; GO:0006508:proteolysis; --- --- >prot|C01G8.9a|cod|C01G8.9a|gene|C01G8.9|ann|let-526 is defined by a single allele that results in early larval lethality. although the let-526 mutation can be rescued by injection of cosmid C01G8, the precise molecular identity of let-526 is not yet known. [Source: WormBase] 1724 2 QQQQQQ 6 100 6 1 42 47 2 ASVAEVAHGGGGPKKDDQVPPAPDASMPTP PNLPPPQQPYEHPAQQHPPQHHSVPPNSFA GO:0008270:zinc ion binding;GO:0005515:protein binding; --- --- --- >prot|C01G8.9a|cod|C01G8.9a|gene|C01G8.9|ann|let-526 is defined by a single allele that results in early larval lethality. although the let-526 mutation can be rescued by injection of cosmid C01G8, the precise molecular identity of let-526 is not yet known. [Source: WormBase] 1724 2 QQQRYHQQQQHQQQQQQ 17 76.4705882352941 6 0.352941176470588 785 801 45 PYGYPPGAPPPAGFHPSHPQHPQHAQYLAW GAPGGPRPPYPYPGGPVPPGPPQNRMPPPP GO:0008270:zinc ion binding;GO:0005515:protein binding; --- --- --- >prot|T13F2.3b|cod|T13F2.3b|gene|T13F2.3|ann|pis-1 encodes an ortholog of mammalian Pax transcription activation domain interacting protein PTIP. PIS-1 has an N-terminal glutamine/asparagine-rich domain and four C-terminal BRCT domains, and is dispensable for obvious functions in mass RNAi assays. mammalian PTIP binds to the activation domain of Pax2 and other Pax proteins, and colocalizes with Pax2 to actively expressed chromatin, and appears to be required for embryonic mitosis (perhaps because of a link between BRCT domains and DNA repair). [Source: WormBase] 1076 1 QQQQQQ 6 100 6 1 174 179 16 GPPTSVPYDYQQAQMQQQQHAQAMAAAAAA HLQQQQYAQNPQQMHDSPYRQHQMMQMHQH GO:0003707:steroid hormone receptor activity;GO:0008270:zinc ion binding;GO:0043565:sequence-specific DNA binding; GO:0006355:regulation of transcription, DNA-dependent; GO:0005634:nucleus; --- >prot|D1007.3|cod|D1007.3|gene|D1007.3|ann|D1007.3 [Source:RefSeq_peptide;Acc:NP_491395] 264 1 QQQQQQ 6 100 6 1 24 29 9 MSPNSPSSSICCCSRYFRRSSSSQQQQQQN NLENIQSTQLEPIEIKVNGQSHLMIPHVAI --- --- --- --- >prot|W04D2.6a|cod|W04D2.6a|gene|W04D2.6|ann|W04D2.6 encodes, by alternative splicing, two isoforms of an ortholog of human RBM25 (RED120). W04D2.6 is required (in conjunction with RSP-6) for normally rapid growth and (in conjunction with CPF-1 and F59A2.4) for oogenesis and embryonic viability. the long isoform of W04D2.6 has both an N-terminal RNA recognition domain (RRM) that is isoform-specific, and a C-terminal nucleic acid-binding domain (PWI) that is found in both isoforms. W04D2.6(RNAi) animals have a relatively subtle slow-growth phenotype, but display more severe synthetic phenotypes in double RNAi against both W04D2.6 and other putative splicing factors (CPF-1, RSP-6, or F59A2.4). W04D2.6 binds the N-terminal region of long UNC-13 isoforms in yeast two-hybrid assays. by orthology, W04D2.6 is expected to participate in splicing and 3'-end formation, and to bind RSR-1. [Source: WormBase] 705 1 QQQQQ 5 100 5 1 17 21 2 MAFRQGYGVSSYPHYPQQQQQIVFGQMRMP IVFGQMRMPGQHTPAQQSSQQKPDSSPVFV --- --- --- --- >prot|T27C4.4a|cod|T27C4.4a|gene|T27C4.4|ann|EGl-27 Related family member (egr-1) [Source:RefSeq_peptide;Acc:NP_504032] 1022 2 QQQQQQ 6 100 6 1 672 677 65 EPVAPTPAASNGTPASQKAAATAAVNTLTP RAAAANMLMTLNSGDKQNLLNVAKEALARG --- GO:0007186:G-protein coupled receptor protein signaling pathway; GO:0016021:integral to membrane; --- >prot|T27C4.4a|cod|T27C4.4a|gene|T27C4.4|ann|EGl-27 Related family member (egr-1) [Source:RefSeq_peptide;Acc:NP_504032] 1022 2 QQQQQ 5 100 5 1 870 874 85 LQHALTQAATGKRSAPQAVASGEPSAKMAK LPTAFAASGSSSWTPIVAPSLEDVGNSLLA --- GO:0007186:G-protein coupled receptor protein signaling pathway; GO:0016021:integral to membrane; --- >prot|F10E7.2|cod|F10E7.2|gene|F10E7.2|ann|F10E7.2 [Source:RefSeq_peptide;Acc:NP_495475] 240 1 QQQQQQQQQQQQQQQGGQPGQ 21 80.9523809523809 15 0.714285714285714 63 83 26 ELNEFDKAACDQSQPDYSTPEGQQAYCAYY KPYAAAAYGGHDQAQQPQNPYAPPPPGADP --- --- --- --- >prot|F53H2.3|cod|F53H2.3|gene|F53H2.3|ann|F53H2.3 [Source:RefSeq_peptide;Acc:NP_507931] 667 2 QQQFQQQQQQQQKKQ 15 80 8 0.533333333333333 205 219 30 TGIFEKQQQQMMQVRRNSSSDDSKSTTPSA KRYRKTLSQQGTTRKEAFGGSQAMSESSEE --- --- --- --- >prot|F53H2.3|cod|F53H2.3|gene|F53H2.3|ann|F53H2.3 [Source:RefSeq_peptide;Acc:NP_507931] 667 2 QQQQQ 5 100 5 1 378 382 56 QAAFLQQAFQLQAQQQASQAPQGAHAPPPP PTMRYYDANSDGFFYEMASVDGWKRRQPNK --- --- --- --- >prot|Y49A3A.3|cod|Y49A3A.3|gene|Y49A3A.3|ann|Y49A3A.3 encodes a conserved but uncharacterized protein with some similarity to Barwin-related endoglucanase. Y49A3A.3 shares an operon with vha-13, and thus might be a previously undescribed V-ATPase component or ancillary protein. [Source: WormBase] 390 1 QQQQQ 5 100 5 1 8 12 2 MELDSVKQQQQQNACCEYILPIKKRRCKML NACCEYILPIKKRRCKMLVKKGNRFCGEHS --- --- --- --- >prot|C27H5.3.1|cod|C27H5.3.1|gene|C27H5.3|ann|C27H5.3 [Source:RefSeq_peptide;Acc:NP_495483] 448 1 QQQQQQQ 7 100 7 1 25 31 5 MAAYDQSQPDYSTPEGQQAYWAYYQQQQQQ PGGQPDQDPYAAAAYGGHDQAQQPQNPYAP --- --- --- --- >prot|Y79H2A.1b.1|cod|Y79H2A.1b.1|gene|Y79H2A.1|ann|brp-1 encodes a glutamine-rich protein that is conserved in nematodes, but that has no known homologies or sequence motifs. BRP-1 is able to bypass the need for the S. cerevisiae mating pheromone MAP kinase cascade to activate the mating pheromone-responsive gene FUSl. [Source: WormBase] 466 2 QQQQQQMQ 8 87.5 6 0.75 133 140 28 MQQMMAMRMMRMRRLQAAYYQQQQMKMAYM EEAARQQWAERSRYEEEQRRQYEAQQTYAQ --- --- --- --- >prot|Y79H2A.1b.1|cod|Y79H2A.1b.1|gene|Y79H2A.1|ann|brp-1 encodes a glutamine-rich protein that is conserved in nematodes, but that has no known homologies or sequence motifs. BRP-1 is able to bypass the need for the S. cerevisiae mating pheromone MAP kinase cascade to activate the mating pheromone-responsive gene FUSl. [Source: WormBase] 466 2 QQQQQHQQQPQQTQQ 15 80 5 0.333333333333333 242 256 51 RFWPRPMMHQQQWERPTVWQQPPQQFFFPS PEDRFPQAPQFFQPIPQPSVHDKIYEELQK --- --- --- --- >prot|F56D1.7|cod|F56D1.7|gene|F56D1.7|ann|daz-1 encodes a protein containing an RNA recognition motif that is required for the progression of meiosis during oogenesis. DAZ-1 is expressed in the germline, and expression levels peak in the proximal pachytene region. cpb-3(bt17).daz-1(tj3) hermaphrodites have a synthetic phenotype of total sterility and masculinization. DAZ-1 colocalizes with CPB-3 in vivo, coimmunoprecipitates with CPB-3, and binds CPB-3 in two-hybrid assays. [Source: WormBase] 498 2 QQQQQQQ 7 100 7 1 290 296 58 ESVSPQPLLPNQNVLNTQYSQGQQQWNSNV MDSNNGGPYYNENYSQGYTRPHPYQQFAQS GO:0005515:protein binding; --- --- --- >prot|F56D1.7|cod|F56D1.7|gene|F56D1.7|ann|daz-1 encodes a protein containing an RNA recognition motif that is required for the progression of meiosis during oogenesis. DAZ-1 is expressed in the germline, and expression levels peak in the proximal pachytene region. cpb-3(bt17).daz-1(tj3) hermaphrodites have a synthetic phenotype of total sterility and masculinization. DAZ-1 colocalizes with CPB-3 in vivo, coimmunoprecipitates with CPB-3, and binds CPB-3 in two-hybrid assays. [Source: WormBase] 498 2 QQQQQHHQ 8 75 5 0.625 362 369 72 SQGMYHSSYSYMTPPLAPGQYPQMMSAPYW SHAYAGYNPAYNNWVGPSGDMNQFKQNPSN GO:0005515:protein binding; --- --- --- >prot|T05A10.1a|cod|T05A10.1a|gene|T05A10.1|ann|sma-9 encodes, by alternative splicing, at least two large (~2000-residue) protein with at least three N-terminal involucrin domains, seven C-terminal zinc-finger domains, and a glutamine/asparagine-rich domain. SMA-9 is orthologous to human HIVEP1 (OMIM:194540), HIVEP2 (OMIM:143054), and HIVEP3 (OMIM:606649), and to Drosophila SCHNURRI (FBgn0003396). SMA-9 proteins are required for growth to normally large body size. [Source: WormBase] 2066 5 QQAQQQQQGQSQ 12 75 5 0.416666666666667 383 394 18 MQAQLQQQLLLQQQQAQAQQAQQAQQAQLA NRTVSQALQYIQSMQLQQRADGTPNGSTRT --- --- --- --- >prot|Y116A8C.32|cod|Y116A8C.32|gene|Y116A8C.32|ann|Y116A8C.32 encodes an ortholog of splicing factor SF1, which enables 3' splice site recognition by binding U2AF65 and the intron branch site during splicing complex formation. Y116A8C.32 shares several domains with mammalian SF1 proteins (a U2AF65 binding domain, a hnRNP K homology domain, two RNA-binding zinc knuckles, and a proline-rich C-terminal domain), while also sharing a hydrophilic N-terminal domain (enriched for serine, arginine, lysine, and aspartate) with Drosophila but not mammalian SF1. Y116A8C.32's N-terminal domain resembles RS domains in other splicing proteins. Y116A8C.32 is required for embryonic viability, normally rapid growth, and proper body morphology. [Source: WormBase] 699 1 QQQQQQQQQQ 10 100 10 1 618 627 88 YDHYQQYAYPNQYQQPYGAPAPPGGSAYGH DYSDFYTSPGARGGAGAKANKGWYGSGGGS --- GO:0006508:proteolysis; --- --- >prot|Y54G2A.3a|cod|Y54G2A.3a|gene|Y54G2A.3|ann|Y54G2A.3 [Source:RefSeq_peptide;Acc:NP_500280] 166 1 QLQQQQQ 7 85.7142857142857 5 0.714285714285714 6 12 3 MINEEQLQQQQQHRRKKKPADEVTQKMPSG HRRKKKPADEVTQKMPSGEKEPMDPYKLEA --- --- --- --- >prot|ZC376.7c|cod|ZC376.7c|gene|ZC376.7|ann|ZC376.7b [Source:RefSeq_peptide;Acc:NP_872160] 474 1 QQQQQTCQQ 9 77.7777777777778 5 0.555555555555556 136 144 28 FWEGKNVTLEAWRPTDSWQNGSSVGHPHGH PPTHSSTTETMHDFSNFGDNMGSPLFQSPS GO:0008324:cation transmembrane transporter activity; --- GO:0016020:membrane; --- >prot|B0513.1|cod|B0513.1|gene|B0513.1|ann|lin-66 encodes an unfamiliar protein, with visible homologs only in nematodes, that was identified in screens for molecules that interact with GEX-3, a homolog of mammalian protein ligands of the small GTPase Rac1, that is essential for ventral enclosure during embryonic development. LIN-66 is expressed in body wall and vulval muscles, and is also detected in the intestine, neurons, and probably the hypodermis. [Source: WormBase] 627 1 QQQSQQQQQPPQ 12 75 5 0.416666666666667 23 34 3 MSYEMNSLFSSNQQPLGGGPPPQQQSQQQQ SLWSLQQFSQMGAPDNFGNHAVPFMPTLGM --- --- --- --- >prot|T12D8.1|cod|T12D8.1|gene|T12D8.1|ann|Temporarily Assigned Gene name family member (tag-350) [Source:RefSeq_peptide;Acc:NP_499819] 2475 1 QQQRQQQQQNQVQQ 14 78.5714285714286 5 0.357142857142857 153 166 6 SLQMQPAPLPSSYPRSQDFNGDVYTQIAAM MLATQAQLMDEISDGGGTNDSDRNSSPFYQ --- --- --- --- >prot|F39B2.4a|cod|F39B2.4a|gene|F39B2.4|ann|sur-2 encodes a novel protein that is orthologous to the Drosophila and human MED23 mediator subunits. sur-2 is a downstream component of the let-60-ras-mediated signaling pathway and likely functions by regulating transcription of genes essential for a number of developmental processes, including vulval development, larval development, and formation of the gonad and male tail. sur-2 is expressed in all Pn.p cells from the mid-L1 through the L3 larval stage, and then in the vulval precursor cells as they divide, with strongest staining observed in the primary and secondary lineages. sur-2 is also expressed in embryonic and other larval stage cells, including the distal tip cells of the gonad. [Source: WormBase] 1587 1 QQQQQ 5 100 5 1 1573 1577 99 MNPMMQNMTPQQQYLYMQQLQQHQQHQQYM HHHQHQQQPH --- --- --- --- >prot|K10D6.2c|cod|K10D6.2c|gene|K10D6.2|ann|K10D6.2 encodes three isoforms of a claudin homolog that may be required for normal cohesion of apical junctions in epithelia. K10D6.2A-C are worm-specific, with obvious homologs only in C. elegans. K10D6.2A-C are required for embryonic viability in mass RNAi assays. claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. [Source: WormBase] 246 1 QQQQQ 5 100 5 1 231 235 93 WIGAFVCTLLTTYKFVTGDEEDGRRYEDRR YHHSSRSTWIN --- --- --- --- >prot|Y48G9A.4|cod|Y48G9A.4|gene|Y48G9A.4|ann|frl-1 encodes a homolog of human FMNL1 (also known as human leukocyte formin) and FMNL2-3, and a paralog of human DAAM1-2. FRL-1 enables Wnt-directed planar cell polarity. FRL-1 is required for the fully asymmetrical division of B.a versus B.p cells, though this requirement is quantitatively weak. [Source: WormBase] 1115 1 QVQQQQQ 7 85.7142857142857 5 0.714285714285714 488 494 43 KDRQAREERKRLEQKIGELEAIQKQMQAGL AAAAAAAAAAQKSPPTPPPPAPGPHKEQRR --- --- --- --- >prot|B0019.1|cod|B0019.1|gene|B0019.1|ann|AMine oXidase family member (amx-2) [Source:RefSeq_peptide;Acc:NP_493236] 724 1 QQSQQQQQ 8 87.5 5 0.625 23 30 3 MLRGWWIFIWAAVCVYAQNTLSQQSQQQQQ PTSANISSSNIQQTIYDVIVVGAGLTGLTA --- GO:0008284:positive regulation of cell proliferation;GO:0031573:intra-S DNA damage checkpoint;GO:0033261:regulation of S phase; GO:0000790:nuclear chromatin; --- >prot|B0041.2a.2|cod|B0041.2a.2|gene|B0041.2|ann|B0041.2 encodes, by alternative splicing, three isoforms of an unfamiliar protein paralogous to AIN-1, and homologous to Brugia malayi 14748.m00068, 14052.m00191, and 14963.m01790. B0041.2 protein binds GEI-4 and GEI-16 in yeast two-hybrid experiments. B0041.2 and its nematode homologs have weak similarity to human TNRC6A (GW182. OMIM:610739) and Drosophila GAWKY. B0041.2 has no obvious function in mass RNAi assays. [Source: WormBase] 706 1 QQRQQQQQPQQ 11 81.8181818181818 5 0.454545454545455 174 184 24 SHMPPYGQRGNNQNQYGNRMQGGQGGYRGN GFNMPPMMVPPGQPPFYGGNQPNHHHQQPS --- GO:0006508:proteolysis; GO:0005622:intracellular; --- >prot|C32A3.1a|cod|C32A3.1a|gene|C32A3.1|ann|sel-8 encodes a nuclear protein required for LIN-12 and GLP-1 signalling. SEL-8 contains a novel motif shared with W09C5.1 and orthologs of W09C5.1 in S. cerevisiae (YER126c), Drosophila (DMIP259), and also has two prominent glutamine-rich domains. [Source: WormBase] 490 2 QQQQQEMQ 8 75 5 0.625 353 360 72 DRMPSTAPPPAQNPQHIAQLQQQQNKMRLM RIEQQRRQQIMQQQQQQQQQEHQRQQMLLQ GO:0050661:NADP or NADPH binding; GO:0006098:pentose-phosphate shunt; --- --- >prot|C32A3.1a|cod|C32A3.1a|gene|C32A3.1|ann|sel-8 encodes a nuclear protein required for LIN-12 and GLP-1 signalling. SEL-8 contains a novel motif shared with W09C5.1 and orthologs of W09C5.1 in S. cerevisiae (YER126c), Drosophila (DMIP259), and also has two prominent glutamine-rich domains. [Source: WormBase] 490 2 QQQQQQQQMQQHHQ 14 78.5714285714286 8 0.571428571428571 390 403 79 QRIEQQRRQQIMQQQQQQQQQEHQRQQMLL MNGGGQFATQAHQQAAYMQQMQRMEQIRHQ GO:0050661:NADP or NADPH binding; GO:0006098:pentose-phosphate shunt; --- --- >prot|C10E2.3|cod|C10E2.3|gene|C10E2.3|ann|hda-4 encodes a class II histone deacetylase that contains a putative MEF-2 DNA binding domain, a nuclear localization signal domain, and a single catalytic domain and may affect locomotion, body morphology, and growth. interacts with MEF-2 in in vitro assays and is expressed in body-wall muscle, neurons, and hypodermal seam cells [Source: WormBase] 869 2 QQQQQLQ 7 85.7142857142857 5 0.714285714285714 80 86 9 RQKQMDLIGHFQRAQQELSVQHMHNLYAAL NLQTERSAVNPLLISQQHSTEDQNSGPAAP --- --- --- --- >prot|C10E2.3|cod|C10E2.3|gene|C10E2.3|ann|hda-4 encodes a class II histone deacetylase that contains a putative MEF-2 DNA binding domain, a nuclear localization signal domain, and a single catalytic domain and may affect locomotion, body morphology, and growth. interacts with MEF-2 in in vitro assays and is expressed in body-wall muscle, neurons, and hypodermal seam cells [Source: WormBase] 869 2 QVQMQQQQQQQQ 12 83.3333333333333 8 0.666666666666667 857 868 98 IAIHKSYWPALHGQEAAINTTEMQWRNLKL T --- --- --- --- >prot|Y51H4A.12|cod|Y51H4A.12|gene|Y51H4A.12|ann|set-26 encodes a large (1,677-residue) protein with a low-complexity N-terminal region, followed by a PHD-zinc finger and a SET domain. SET-26 has no non-nematode orthologs, but has 96% identity (1616/1679 residues) to its paralog SET-9. unlike its paralog SET-9, SET-26 has no obvious function in RNAi assays. [Source: WormBase] 1677 1 QQQQQ 5 100 5 1 712 716 42 FTGQSGSSAAARQRTVSGSAARAQTYQMHH HHHQMPMDQRKRHSSGRYDALMGAMPLQQQ --- --- --- --- >prot|C10C5.6b|cod|C10C5.6b|gene|C10C5.6|ann|daf-15 encodes an ortholog of RAPTOR (the regulatory associated protein of mTOR), and is regulated by DAF-16. daf-15 is required for non-dauer development, at least in some tissues or stages. daf-15(m81) mutants constitutively and irreversibly form abnormal dauer-like larvae (and are thus effectively lethal/sterile). mutants do not form true dauers when exposed to dauer pheromone, yet execute only two molts. [Source: WormBase] 1782 1 QQQQQQ 6 100 6 1 688 693 38 MDPSGGQHSPNAQPRQPQPQQPQQLQQQPS SRQPQGIMKPTNAQPQEKKTMLRFQYFLQL GO:0004176:ATP-dependent peptidase activity;GO:0004252:serine-type endopeptidase activity; GO:0006508:proteolysis; --- --- >prot|C09F9.3a|cod|C09F9.3a|gene|C09F9.3|ann|C09F9.3 [Source:RefSeq_peptide;Acc:NP_001021945] 791 1 QQQLQLQQQQQQ 12 83.3333333333333 6 0.5 695 706 87 LVRRKSSKAPPTPDYKPPQFGYGALPVSKY NEKKASQDKHRNINGHGHMNGNGTHTNGNH GO:0005230:extracellular ligand-gated ion channel activity; GO:0006811:ion transport; GO:0016021:integral to membrane;GO:0045211:postsynaptic membrane; --- >prot|Y67D8C.7|cod|Y67D8C.7|gene|Y67D8C.7|ann|Y67D8C.7 [Source:RefSeq_peptide;Acc:NP_500288] 158 1 QQQQQQ 6 100 6 1 131 136 82 GGNKYGGGGGGSKYGGGQQQQPQQQQGGYG PSKYGGGGQEQQQGGGSSGGNY --- --- --- --- >prot|F47A4.2|cod|F47A4.2|gene|F47A4.2|ann|dpy-22 encodes a broadly expressed protein, homologous to the human transcriptional mediator protein TRAP230, which is involved in WNT and RAS signaling, as well as in dosage compensation. DPY-22 has a C-terminal glutamine-rich domain that is dispensable for inhibition of RAS-dependent cell differentiation, but is required for inhibition of BAR-1-dependent gene expression. [Source: WormBase] 3498 3 QQQQQ 5 100 5 1 2904 2908 83 HTQNQLSLAQKEKEKQYFQAKNLQASQANA RFGDVVAGNVAGYGRPYGQQQLGASDQMGT --- --- --- --- >prot|F47A4.2|cod|F47A4.2|gene|F47A4.2|ann|dpy-22 encodes a broadly expressed protein, homologous to the human transcriptional mediator protein TRAP230, which is involved in WNT and RAS signaling, as well as in dosage compensation. DPY-22 has a C-terminal glutamine-rich domain that is dispensable for inhibition of RAS-dependent cell differentiation, but is required for inhibition of BAR-1-dependent gene expression. [Source: WormBase] 3498 3 QQVGQQAQQQQQQ 13 76.9230769230769 6 0.461538461538462 3074 3086 87 GGYQQGQQQSGQGSYPQAQQQQPNQYSGSN PLNQNVSQSQSAAQFGRPSQDSAYQQSGYN --- --- --- --- >prot|F47A4.2|cod|F47A4.2|gene|F47A4.2|ann|dpy-22 encodes a broadly expressed protein, homologous to the human transcriptional mediator protein TRAP230, which is involved in WNT and RAS signaling, as well as in dosage compensation. DPY-22 has a C-terminal glutamine-rich domain that is dispensable for inhibition of RAS-dependent cell differentiation, but is required for inhibition of BAR-1-dependent gene expression. [Source: WormBase] 3498 3 QQQQQQDQ 8 87.5 6 0.75 3382 3389 96 QNQRGMNPGAQLPPYSTGQQQHQPQQSQIS YRRMQAAQMQQQPTAQGQQNRMGMPSQQQS --- --- --- --- >prot|Y37A1B.17b|cod|Y37A1B.17b|gene|Y37A1B.17|ann|Y37A1B.17a [Source:RefSeq_peptide;Acc:NP_001076722] 1467 1 QQQQQVQ 7 85.7142857142857 5 0.714285714285714 1184 1190 80 AQNAQFDWNMAAKTLPLAPAPPMQVSQQAP EGAGGANYNLDLDNLFSGLSTIDWGAKTST GO:0003677:DNA binding; GO:0006334:nucleosome assembly; GO:0005634:nucleus; --- >prot|F13E6.4|cod|F13E6.4|gene|F13E6.4|ann|F13E6.4 [Source:RefSeq_peptide;Acc:NP_509789] 442 1 QQQQQAQNSQQQQ 13 76.9230769230769 5 0.384615384615385 346 358 78 GLVDSPQPPYQAISPMSSTMMHSHDPNFMY TPHTLHQIPNQYQNSQMNDDSAMEVDYSMV --- --- --- --- >prot|F09C8.2.1|cod|F09C8.2.1|gene|F09C8.2|ann|F09C8.2 [Source:RefSeq_peptide;Acc:NP_510635] 762 1 QQQQQQQQHQ 10 90 8 0.8 139 148 18 QPRVSFSDEELYQALNMSPLPPTATFHALH SMKQQHAMHLQQQPQTDYLSSEVCYPSTSS --- --- --- --- >prot|W10D5.3a|cod|W10D5.3a|gene|W10D5.3|ann|gei-17 encodes a protein containing a MIZ domain (Msx-interacting-zinc finger) that affects embryonic viability, vulval development, and body morphology. interacts with GEX-3 in yeast two-hybrid assays. [Source: WormBase] 692 1 QQQQQQQPQ 9 88.8888888888889 7 0.777777777777778 131 139 18 RPATTSQVRSHPYVLPSRSGASNHLVNHHY PHNLLHQQMMASHHSHLQQQHHPSTPKKMY GO:0008270:zinc ion binding;GO:0003676:nucleic acid binding; --- --- --- >prot|Y105E8A.24b|cod|Y105E8A.24b|gene|Y105E8A.24|ann|Y105E8A.24a [Source:RefSeq_peptide;Acc:NP_001021683] 1127 1 QQQQQ 5 100 5 1 16 20 1 MGLNEKWTRIVERRGQQQQQRHRRQSSGTS RHRRQSSGTSGGGASNLDANTLKVLPTTTS GO:0005515:protein binding; --- --- --- >prot|C08F8.3|cod|C08F8.3|gene|C08F8.3|ann|C08F8.3 [Source:RefSeq_peptide;Acc:NP_502090] 400 1 QLQQQQQQ 8 87.5 6 0.75 319 326 79 TTPAQMMPTASSFRIPFAQVSKAPVVAPSS PCSSNQTARIGNFLERDQVRGNLLGVPLSS --- --- --- --- >prot|Y47D7A.13|cod|Y47D7A.13|gene|Y47D7A.13|ann|Y47D7A.13 [Source:RefSeq_peptide;Acc:NP_504226] 311 1 QQQQQ 5 100 5 1 226 230 72 QQQAPAQGAGYQQQAPAAVVTEQQQVGQGY APVQEQAPAPVQEQAPAASYGEQAPVQAQQ --- --- --- --- >prot|F52G2.2b.2|cod|F52G2.2b.2|gene|F52G2.2|ann|RNAi Spreading Defective (see also sid) family member (rsd-2) [Source:RefSeq_peptide;Acc:NP_001040952] 1129 1 QNEQQQQQ 8 75 5 0.625 957 964 84 LDRRNLRGNTIEEVRDDISIQKRIAHMNFG SSLSSRGPTRPYSPVGSYQSSHQNFDNRSA GO:0005515:protein binding; --- --- --- >prot|C07G1.5.1|cod|C07G1.5.1|gene|C07G1.5|ann|hgrs-1 encodes a VHS and FYVE zinc finger-domain containing protein that is the C. elegans ortholog of S. cerevisiae Vps27p and mammalian hepatocyte growth factor-regulated tyrosine kinase substrate (HGS). hgrs-1 activity is essential for molting and thus for proper larval development. consistent with its proposed role in the endocytic pathway, HGRS-1 is also required for proper trafficking of the LRP-1 low-density lipoprotein receptor-related protein 1 and for endosome maturation and regulation of autophagic vesicle accumulation. an HGRS-1::GFP fusion protein is widely expressed, but particularly enriched in epithelial cells. within cells, HGRS-1::GFP localizes to endosomal membranes. [Source: WormBase] 729 2 QQQQQ 5 100 5 1 533 537 73 QAQMQQTLEMMRMKKHAMLMEQREQALQRF EMAMRRHQQQAYYNPQQMGYGAPPPSGPQQ --- --- --- --- >prot|C07G1.5.1|cod|C07G1.5.1|gene|C07G1.5|ann|hgrs-1 encodes a VHS and FYVE zinc finger-domain containing protein that is the C. elegans ortholog of S. cerevisiae Vps27p and mammalian hepatocyte growth factor-regulated tyrosine kinase substrate (HGS). hgrs-1 activity is essential for molting and thus for proper larval development. consistent with its proposed role in the endocytic pathway, HGRS-1 is also required for proper trafficking of the LRP-1 low-density lipoprotein receptor-related protein 1 and for endosome maturation and regulation of autophagic vesicle accumulation. an HGRS-1::GFP fusion protein is widely expressed, but particularly enriched in epithelial cells. within cells, HGRS-1::GFP localizes to endosomal membranes. [Source: WormBase] 729 2 QQQQQQ 6 100 6 1 599 604 82 PQQSYYGYQQGPQSQAPPPSSQYQQSHAST YYQHYQANQTVTQPVQQAQQQYQQQYQGYY --- --- --- --- >prot|K07F5.13c|cod|K07F5.13c|gene|K07F5.13|ann|npp-1 encodes a nucleoporin that is most closely related to the vertebrate nucleoporin Nup54 and Saccharomyces cerevisiae nucleoporin Nup57p. during embryonic development, npp-1 activity is essential for some aspects of nuclear structure and function, as well as for proper mitotic spindle orientation, asymmetric cell division, cell fate specification, and mitotic cell cycle timing. npp-1 is also required for normal oogenesis and levels of fertility and for effective RNA interference (RNAi). an NPP-1::GFP reporter is expressed at all stages of development and localizes to the nuclear envelope. the NPP-1C isoform interacts with itself and with nucleoporins NPP-3, NPP-4, NPP-11, and NPP-13B in yeast two-hybrid assays. [Source: WormBase] 639 1 QQQQQ 5 100 5 1 239 243 37 TLFGSSTAKPATGGFFGSSSGSTLGGLGAT PVVQQQQVIQQYHPFVKAVGDPKLFGNDND --- --- --- --- >prot|W02A11.3|cod|W02A11.3|gene|W02A11.3|ann|W02A11.3 [Source:RefSeq_peptide;Acc:NP_493231] 489 1 QQQQQQHQQ 9 88.8888888888889 6 0.666666666666667 234 242 47 RMQLEHRLQQITGPVPGSEHNCMTGCPHLH PLLHIQLNPIPPQPQTGPNSVSPTIAPGAM --- --- --- --- >prot|T02C5.5e|cod|T02C5.5e|gene|T02C5.5|ann|unc-2 encodes a calcium channel alpha subunit required for desensitization to dopamine, normal flexion and speed during movement, normally low sensitivity of whole animals to serotonin, and neuronal migrations promoted by humoral serotonin. UNC-2 is orthologous to human CACNA1A (OMIM:601011, mutated in familiar hemiplegic migraine or episodic ataxia 2) and to Drosophila CACOPHONY. UNC-2 is expressed primarily in motor neurons, several sensory neurons, and HSN and VC neurons controlling egg-laying. [Source: WormBase] 2087 1 QDQQQQQQ 8 87.5 6 0.75 1862 1869 89 YQMSIRDPIIRRNRYNTMEHSRSSHDPQYH PHHQQHSQHLQHSHHKTYQNHNQYSRSPIY --- --- --- --- >prot|F57A8.2b|cod|F57A8.2b|gene|F57A8.2|ann|F57A8.2a [Source:RefSeq_peptide;Acc:NP_001041126] 380 1 QQQQQQQ 7 100 7 1 72 78 18 GGYYSQQSSNQGFDGYGQQSPTQNQYGGYG SYGQNNGFGGFQPQQLMSDPMLNAAKQFGG --- --- --- --- >prot|T23D8.9b|cod|T23D8.9b|gene|T23D8.9|ann|sys-1 encodes a novel protein that contains three divergent armadillo repeats. during gonadogenesis, SYS-1 functions in a Wnt/MAPK signaling pathway as a dosage-dependent beta-catenin-like transcriptional coactivator required for specification of distal cell fates. consistent with its role as a beta-catenin, SYS-1 interacts, in yeast two-hybrid and coimmunoprecipitation assays, with the POP-1/TCF transcription factor with which it can stimulate transcription via TCF binding sites. in two hybrid-assays, the POP-1/SYS-1 interaction requires the N-terminal beta-catenin binding domain of POP-1, and most of the SYS-1 protein. a VNS::SYS-1 reporter fusion protein is expressed in several tissues during embryonic and larval development and localizes to both the nucleus and cytoplasm as well as to what appears to be the centrosomes. in many tissues, SYS-1 is distributed asymmetrically, in a manner reciprocal to the asymmetric distribution of POP-1. [Source: WormBase] 239 1 QQQQQVQQQQQRQ 13 84.6153846153846 5 0.384615384615385 76 88 31 PYHPQQHPNYISMQPPPSQQQQMTPQALST LYSSPSPSRGPAAPAQNQKFRTEQWINNQA GO:0008270:zinc ion binding; --- --- --- >prot|Y42H9AR.1.3|cod|Y42H9AR.1.3|gene|Y42H9AR.1|ann|Y42H9AR.1 [Source:RefSeq_peptide;Acc:NP_501354] 506 2 QQQQQQQAYQ 10 80 7 0.7 366 375 72 SPAPAPVSSPTPVQQYQQSYSQAQPPVDYY PPVNPPTSYQAYQPPVPTSYYPPAASTASN --- GO:0007165:signal transduction; GO:0016020:membrane; --- >prot|Y42H9AR.1.3|cod|Y42H9AR.1.3|gene|Y42H9AR.1|ann|Y42H9AR.1 [Source:RefSeq_peptide;Acc:NP_501354] 506 2 QQQQQ 5 100 5 1 492 496 97 MPSLSSIGITQLATPPVPGATSYQPPSFPP YGAYPPAPPQ --- GO:0007165:signal transduction; GO:0016020:membrane; --- >prot|Y94H6A.11|cod|Y94H6A.11|gene|Y94H6A.11|ann|Y94H6A.11 [Source:RefSeq_peptide;Acc:NP_001041062] 287 1 QQQQQQQQQQ 10 100 10 1 2 11 0 MQQQQQQQQQQAPHPHQNQHAQLINRIISS APHPHQNQHAQLINRIISSAYNNQHDNGSF --- --- --- --- >prot|Y66D12A.12|cod|Y66D12A.12|gene|Y66D12A.12|ann|Y66D12A.12 [Source:RefSeq_peptide;Acc:NP_499490] 343 1 QQQQQQ 6 100 6 1 165 170 48 RPSSKAMKTSDTPLTGHDQILALLSNLMSA APVATPTIPASWIDQLLAATPALLPFMPSS --- --- --- --- >prot|F16C3.1|cod|F16C3.1|gene|F16C3.1|ann|F16C3.1 [Source:RefSeq_peptide;Acc:NP_492672] 399 1 QQQQQQ 6 100 6 1 247 252 61 NSFSTYRYRQCMKIYSSGVLRVRFVRAPTT LNNDTIQFEETTVKKYLLSTDNTHSNLPTS --- --- --- --- >prot|T13H2.5a|cod|T13H2.5a|gene|T13H2.5|ann|spat-3 encodes, by transcription from alternative promoters, two large (1092- and 2471-residues) proteins. while residues 162-228 of the larger SPAT-3 protein encode a Ring1 type of zinc-finger domain (like that seen in SEX COMBS EXTRA, an E3 ubiquitin-protein ligase RING1 protein of Drosophila melanogaster), the bulk of SPAT-3 has no obvious similarities to other proteins. SPAT-3 is specifically required for PAR protein-dependent cell-polarity, and this requirement is independent of PAR-2 activity. as with par-3, par-6, pkc-3, and cdc-42, inactivation of spat-3 (by RNAi or mutation) strongly suppresses the embryonic lethality of par-2(it5ts) at restrictive temperature. as with nos-3, spat-3 also suppresses par-2(lw32), a strong loss-of-function allele. while spat-3 par-2 double mutant embryos require PAR-1 for viability, PAR-1 does not regain posterial cortical localization in these embryos, but is instead diffused through their cytoplasm. [Source: WormBase] 2471 1 QQQQQQIQMQQQQQLAQQ 18 77.7777777777778 6 0.333333333333333 2236 2253 90 QLFMQLQLQQQQLMQHQLQQQLQMQQHQQH GLVPNVSSAWLQQQAQLAQQQQQVVQQNLL --- --- --- --- >prot|R10E4.2c|cod|R10E4.2c|gene|R10E4.2|ann|Temporarily Assigned Gene name family member (tag-310) [Source:RefSeq_peptide;Acc:NP_497856] 150 1 QQQQQQQQPQQGQAPQQQQQ 20 80 8 0.4 8 27 5 MNASSAPQQQQQQQQPQQGQAPQQQQQGPP GPPQHQYQQQRPFHGHSMNNPEMLQRMQYP GO:0005230:extracellular ligand-gated ion channel activity; GO:0006811:ion transport; GO:0016021:integral to membrane;GO:0045211:postsynaptic membrane; --- >prot|D2045.1b.2|cod|D2045.1b.2|gene|D2045.1|ann|atx-2 is required for early embryonic patterning. it encodes an ortholog of human ataxin-2, which when mutated leads to spinocerebellar ataxia 2 (SCA2. OMIM:183090). [Source: WormBase] 634 2 QQQQQQQPQQQQ 12 91.6666666666667 7 0.583333333333333 389 400 61 YQQRYQQPQVYMMPPQGQQQQPRYQGPPPP FSGEQSRPQSHPNSQPTTPGPRGELPKMSG --- GO:0006869:lipid transport; --- --- >prot|D2045.1b.2|cod|D2045.1b.2|gene|D2045.1|ann|atx-2 is required for early embryonic patterning. it encodes an ortholog of human ataxin-2, which when mutated leads to spinocerebellar ataxia 2 (SCA2. OMIM:183090). [Source: WormBase] 634 2 QQQQQQQQQQMHRQ 14 78.5714285714286 10 0.714285714285714 577 590 91 QHPQQSLMGERSDQGFPTSGYFDYRTMPNY NSLPQQFQGNQGVNPSGQQSGPPPPPPPSQ --- GO:0006869:lipid transport; --- --- >prot|R12B2.5b.2|cod|R12B2.5b.2|gene|R12B2.5|ann|mdt-15 encodes, by alternative splicing, two isoforms of a Mediator subunit orthologous to human MED15 (OMIM:607372, deleted in DiGeorge syndrome). together with NHR-49 and SBP-1, MDT-15 is required for normal fat accumulation, for expression of fatty acid (FA) desaturase genes (fat-5, fat-6, and fat-7), for normal levels of mono- and polyunsaturated FAs (PUFAs), and for viability, fecundity, mobility, and normally long lifespan. several of these phenotypes can be at least partially suppressed by supplying PUFAs in the food medium. in part through NHR-49, MDT-15 participates in basal and fasting-induced transcription of numerous other metabolic genes, such as gei-7 and acs-2. independently of NHR-49 and SBP-1, MDT-15 ensures appropriate transcriptional response and survival in response to toxins and heavy metals by inducing select detoxification genes encoding such as cdr-1, cyp-35C1, gst-5, mtl-1, mtl-2, ugt-1, ugt-8, and others. mdt-15 is expressed at constant levels from embryos to adulthood, in several head neurons and intestine. MDT-15 binds NHR-49 and NHR-64 in yeast two-hybrid assays, and SBP-1 in GST pull-down assays. [Source: WormBase] 777 1 QRAAAQQQQQQQQQQQQQ 18 77.7777777777778 13 0.722222222222222 332 349 42 SVLESLINQPQQYPGHHNQMGPPGDRNVAA RPGMVPNQGMMSSEDQTVYSAKLRNMRGSC GO:0008312:7S RNA binding;GO:0000166:nucleotide binding;GO:0017111:nucleoside-triphosphatase activity; GO:0006614:SRP-dependent cotranslational protein targeting to membrane; GO:0016020:membrane;GO:0048500:signal recognition particle; --- >prot|T06D8.3|cod|T06D8.3|gene|T06D8.3|ann|T06D8.3 [Source:RefSeq_peptide;Acc:NP_496399] 396 1 QQQQQQQQGHQ 11 81.8181818181818 8 0.727272727272727 380 390 95 NGTLRNRHNQGNRQYEVTTTTESFHRTISP NDGYRY --- --- --- --- >prot|W05H7.4e|cod|W05H7.4e|gene|W05H7.4|ann|W05H7.4b [Source:RefSeq_peptide;Acc:NP_741719] 666 1 QQQQQQ 6 100 6 1 320 325 48 LLQVKPNQGFHTLPLYHSQRPENPRRPMYA SAHQTPTPHIQQVFQETEPVTNYYTATTSV --- --- --- --- >prot|Y49E10.29|cod|Y49E10.29|gene|Y49E10.29|ann|Putative uncharacterized protein. [Source:UniProtKB/TrEMBL;Acc:A3FPL3] 559 1 QQQQQAQ 7 85.7142857142857 5 0.714285714285714 33 39 5 RFLVFGLLFVSVAGQQQVPVIQQAPPNSPA AHAPPAQAKPIVQQTQPAQKQQAQAPPAAQ --- --- --- --- >prot|C34G6.7a|cod|C34G6.7a|gene|C34G6.7|ann|pqn-19 encodes, by alternative splicing, two isoforms of a putative Janus kinase substrate ('signal-transducing adaptor molecule') that is required for maintaining meiotic arrest and for acetylcholine neurotransmission. PQN-19 is located in puncta of the DA motor neurons. PQN-19 is required in the germline for arrested oocytes to continue responding to an inhibitory signal from somatic gonadal sheath cells, before the oocytes have been induced by major sperm protein (MSP) to exit meiotic prophase. PQN-19 has an N-terminal VSH domain, a central ubiquitin-interacting motif and SH3 domain, and a C-terminal glutamine/asparagine (Q/N)-rich domain. PQN-19 is orthologous to human STAM (OMIM:601899) and STAM2 (OMIM:606244). [Source: WormBase] 457 1 QPQQQQQQ 8 87.5 6 0.75 439 446 96 QQQQPQQYPPQHYPAPGAQPQYACPPNSVP WPAPSSQPQQY --- --- --- --- >prot|M6.1c|cod|M6.1c|gene|M6.1|ann|ifc-2 encodes three isoforms of an intermediate filament protein dispensable for viability but required for normal movement, growth rate, body size, body shape, and cuticle strength. IFC-2 is present in the cytoplasm of intestinal cells, and at the desmosomes of intestinal and pharyngeal cells. [Source: WormBase] 685 1 QQQQQ 5 100 5 1 296 300 43 TEEYKIQEEYIVQRYDNGSSPNYQRQEQGY HRSREYKTHRQEKQENYNQRSYSATENREV --- --- --- --- >prot|C14B9.6c|cod|C14B9.6c|gene|C14B9.6|ann|gei-8 encodes a novel protein highly similar to C. briggsae BP:CBP04038 that contains a glutamine/asparagine (Q/N)-rich ('prion') domain (by the algorithm of Michelitsch and Weissman) and two myb-like DNA-binding domains. interacts with GEX-3 in yeast two-hybrid assays. [Source: WormBase] 1783 5 QQQQQQQPQAQ 11 81.8181818181818 7 0.636363636363636 739 749 41 RPTPTSSSSHLIGSSSVGGSERELGGRGLV SAAPPVTVSTAAAATAERLVNATSPSPSVA --- --- --- --- >prot|C14B9.6c|cod|C14B9.6c|gene|C14B9.6|ann|gei-8 encodes a novel protein highly similar to C. briggsae BP:CBP04038 that contains a glutamine/asparagine (Q/N)-rich ('prion') domain (by the algorithm of Michelitsch and Weissman) and two myb-like DNA-binding domains. interacts with GEX-3 in yeast two-hybrid assays. [Source: WormBase] 1783 5 QQQQQQQQQPQQ 12 91.6666666666667 9 0.75 872 883 48 STPAQILTPTPVRPTAASTPSMDQFLGLFK SNLMQQLGNINPQFLALLLQQQQQQQQVQQ --- --- --- --- >prot|C14B9.6c|cod|C14B9.6c|gene|C14B9.6|ann|gei-8 encodes a novel protein highly similar to C. briggsae BP:CBP04038 that contains a glutamine/asparagine (Q/N)-rich ('prion') domain (by the algorithm of Michelitsch and Weissman) and two myb-like DNA-binding domains. interacts with GEX-3 in yeast two-hybrid assays. [Source: WormBase] 1783 5 QQQQQQQQVQQAQVQ 15 80 8 0.533333333333333 903 917 50 QQQQQQQQPQQSNLMQQLGNINPQFLALLL AAQTQGSLTSGTPFQAQQRPDEALQKLFSS --- --- --- --- >prot|C14B9.6c|cod|C14B9.6c|gene|C14B9.6|ann|gei-8 encodes a novel protein highly similar to C. briggsae BP:CBP04038 that contains a glutamine/asparagine (Q/N)-rich ('prion') domain (by the algorithm of Michelitsch and Weissman) and two myb-like DNA-binding domains. interacts with GEX-3 in yeast two-hybrid assays. [Source: WormBase] 1783 5 QQQHLQQQQQ 10 80 5 0.5 1279 1288 71 QNNIGIRQAQPQDREKLLQEQQLNQYLFAA HHGTQPEQKSKRKSGIESITSMQGAPHRHI --- --- --- --- >prot|C14B9.6c|cod|C14B9.6c|gene|C14B9.6|ann|gei-8 encodes a novel protein highly similar to C. briggsae BP:CBP04038 that contains a glutamine/asparagine (Q/N)-rich ('prion') domain (by the algorithm of Michelitsch and Weissman) and two myb-like DNA-binding domains. interacts with GEX-3 in yeast two-hybrid assays. [Source: WormBase] 1783 5 QQLQQQQQ 8 87.5 5 0.625 1587 1594 89 LSAAEKLALQQYQIHSAHQKSQQQAQLQAA ARPDHYEKFHLLRPNAEIVRPIPTTFSHFL --- --- --- --- >prot|W05F2.4a|cod|W05F2.4a|gene|W05F2.4|ann|W05F2.4a [Source:RefSeq_peptide;Acc:NP_001032983] 2122 1 QQQQQ 5 100 5 1 1776 1780 83 TRGRAQNFVAPVAEPMTSKAPIYSQAVRPK KSLDEVTSMLNRAVSQFGNEQRQAYQHPTA --- --- --- --- >prot|F59F3.2|cod|F59F3.2|gene|F59F3.2|ann|F59F3.2 [Source:RefSeq_peptide;Acc:NP_509837] 430 1 QQQQQQQPFQ 10 80 7 0.7 344 353 80 VSTSRNRLTSNNNDAVDDYEAEVERHVTPR RRRWQKTNQQNQRDMYVNLRKNTHSDLIDV --- --- --- --- >prot|C45E5.6a.1|cod|C45E5.6a.1|gene|C45E5.6|ann|Nuclear Hormone Receptor family member (nhr-46) [Source:RefSeq_peptide;Acc:NP_001023065] 528 1 QQQQQ 5 100 5 1 24 28 4 MKSDWSTDFFHQSQTPNPYPPIVQQQQQPP PPHTSSSFFNTNHQLNSHYSSPIHQPPTSL --- --- --- --- >prot|C07A12.7a.1|cod|C07A12.7a.1|gene|C07A12.7|ann|C07A12.7a [Source:RefSeq_peptide;Acc:NP_508777] 437 1 QQQQNQQQQQQPQQGQQ 17 82.3529411764706 6 0.352941176470588 209 225 47 FPAADLDTLAPIKTPKRTVFNQPPPATLDD NPQSTYDVLTIREQGQEPISATPAQLTKLR --- --- --- --- >prot|Y69H2.14.1|cod|Y69H2.14.1|gene|Y69H2.14|ann|Y69H2.14 [Source:RefSeq_peptide;Acc:NP_872207] 338 1 QQQQQ 5 100 5 1 107 111 31 VTGQQSRIKRQYVTGPMGGGGGYGGGGYGH NYGHQGYAQRPQQPQPVYRPSAPVYQPQPQ --- --- --- --- >prot|Y73B6A.5a.1|cod|Y73B6A.5a.1|gene|Y73B6A.5|ann|The lin-45 gene encodes an ortholog of the vertebrate protein RAF which is required for larval viability, fertility and the induction of vulval cell fates. [Source: WormBase] 813 1 QQQQQ 5 100 5 1 637 641 78 NIFLMDDMSTVKIGDFGLATVKTKWTVNGG PTGSILWMAPEVIRMQDDNPYTPQSDVYSF GO:0005524:ATP binding;GO:0004713:protein tyrosine kinase activity;GO:0004674:protein serine/threonine kinase activity; GO:0006468:protein amino acid phosphorylation; --- --- >prot|F42A6.7c|cod|F42A6.7c|gene|F42A6.7|ann|The hrp-1 gene encodes a homolog of the human DRPLA gene (OMIM:125370), which when mutated leads to dentatorubral-pallidoluysian atrophy or to Haw River syndrome (OMIM:140340). [Source: WormBase] 308 1 QQQQQ 5 100 5 1 260 264 84 QGGWGGPQQQQGGGGWGQQGGGGQGGWGGP GGWGGPQQGGGGGGWGGQGQQQGGWGGQSG --- --- --- --- >prot|Y63D3A.5.1|cod|Y63D3A.5.1|gene|Y63D3A.5|ann|human TFG related family member (tfg-1) [Source:RefSeq_peptide;Acc:NP_493462] 486 2 QQQQQQFQ 8 87.5 6 0.75 258 265 53 AIPPPNATIPSFPTSNAASPPVQEFAPPPP APPPPMASHSSISSTPVQQQGFAPPQQFGG --- --- --- --- >prot|Y63D3A.5.1|cod|Y63D3A.5.1|gene|Y63D3A.5|ann|human TFG related family member (tfg-1) [Source:RefSeq_peptide;Acc:NP_493462] 486 2 QQQQQQ 6 100 6 1 312 317 64 VQQQGFAPPQQFGGPPPSGPPSEYGGYAPP FGAPPPQGAPQQGFGAPPQGPPQGGPPQGS --- --- --- --- >prot|M01E11.7c|cod|M01E11.7c|gene|M01E11.7|ann|Temporarily Assigned Gene name family member (tag-163) [Source:RefSeq_peptide;Acc:NP_491637] 949 1 QQQQQEQ 7 85.7142857142857 5 0.714285714285714 292 298 30 FDAVTDPLDDVLESTKRLGSAYSVGDVRGG HNASNDFNFSNTLNNTPTDYRQHYRNRNCQ GO:0005515:protein binding;GO:0008270:zinc ion binding; --- GO:0005622:intracellular; --- >prot|Y75B8A.8|cod|Y75B8A.8|gene|Y75B8A.8|ann|Y75B8A.8 [Source:RefSeq_peptide;Acc:NP_499581] 715 4 QQQQQQQNQ 9 88.8888888888889 7 0.777777777777778 115 123 16 FQQEVHNVNERIRGAMTQYAAQCSQRAAAA AAGQMPPPQMAPVMMSAAEKKKQMEMQKHQ --- --- --- --- >prot|Y75B8A.8|cod|Y75B8A.8|gene|Y75B8A.8|ann|Y75B8A.8 [Source:RefSeq_peptide;Acc:NP_499581] 715 4 QQQQQQ 6 100 6 1 177 182 24 MEMQKHQRMAQQQQMQQQQGGMSFPPGSTL MRMQFQRQQQQQQQQLQQNPQNQGYGRMGG --- --- --- --- >prot|Y75B8A.8|cod|Y75B8A.8|gene|Y75B8A.8|ann|Y75B8A.8 [Source:RefSeq_peptide;Acc:NP_499581] 715 4 QQQQQ 5 100 5 1 220 224 30 QQQQQQQQLQQNPQNQGYGRMGGGPQYPGM LTHQNPGMQQQQMQQPQMQQTPQSHGPIPV --- --- --- --- >prot|Y75B8A.8|cod|Y75B8A.8|gene|Y75B8A.8|ann|Y75B8A.8 [Source:RefSeq_peptide;Acc:NP_499581] 715 4 QQQQQIQQQ 9 88.8888888888889 5 0.555555555555556 323 331 45 QQQHPGMGGPEMGGHMHAQQGAPGSQAAPV APPQAPAEKTEDMKYKELLKEMKLQYLEAL --- --- --- --- >prot|F39H11.3|cod|F39H11.3|gene|F39H11.3|ann|cdk-8 encodes a member of the cyclin-dependent serine/threonine protein kinase family orthologous to human CDK8 (OMIM:603184) which functions in transcriptional regulation with the positive regulatory factor cyclin C, is associated with the RNA polymerase II holoenzyme, and may regulate gene-specific activators. CDK-8 also contains a glutamine/asparagine-rich domain. loss of cdk-8 function via RNA-mediated interference (RNAi) results in sterility in the injected hermaphrodite, suggesting that in C. elegans, CDK-8 may play a role in germ-line development. [Source: WormBase] 588 1 QQQQQQWQQQ 10 90 6 0.6 576 585 97 MRAPGVPPQGYMPGRGMAPPQMGQQQPGPN YHR --- --- --- --- >prot|Y54G2A.26b.1|cod|Y54G2A.26b.1|gene|Y54G2A.26|ann|Y54G2A.26a [Source:RefSeq_peptide;Acc:NP_001023499] 549 1 QQQQQ 5 100 5 1 62 66 11 TSNPYYQPPVPPQHHHMQPQAPMMSPGMHG PYYNTQSPLTGTPPSMSYGTPQIPAPPPTS GO:0004190:aspartic-type endopeptidase activity; GO:0006508:proteolysis; --- --- >prot|Y17G7B.24|cod|Y17G7B.24|gene|Y17G7B.24|ann|Y17G7B.24 [Source:RefSeq_peptide;Acc:NP_001022415] 117 1 QQQQQ 5 100 5 1 72 76 61 IKKISIPTVNVHKMSLTNAECLTVHQQIPP LYPNSMVPPSDRFTRSASSSPRRGGANGGG --- GO:0006810:transport; GO:0016020:membrane;GO:0016021:integral to membrane; --- >prot|T09A5.6|cod|T09A5.6|gene|T09A5.6|ann|Mediator of RNA polymerase II transcription subunit 10 (Mediator complex subunit 10) (CeMED10) (CeNUT2). [Source:UniProtKB/Swiss-Prot;Acc:P45966] 173 1 QQQQQSQQ 8 87.5 5 0.625 3 10 1 MVQQQQQSQQRMMELHERNDREKLARKTEK RMMELHERNDREKLARKTEKEREEERRKQE --- --- --- --- >prot|Y48E1B.14b|cod|Y48E1B.14b|gene|Y48E1B.14|ann|Y48E1B.14a [Source:RefSeq_peptide;Acc:NP_496844] 155 1 QQQQQ 5 100 5 1 8 12 5 MNMSDPKQQQQQKIHVGAAVVLLTAIFYAA KIHVGAAVVLLTAIFYAADFGFVSILVVIG GO:0005524:ATP binding;GO:0000166:nucleotide binding;GO:0004827:proline-tRNA ligase activity; GO:0006418:tRNA aminoacylation for protein translation;GO:0006412:translation;GO:0006433:prolyl-tRNA aminoacylation; GO:0005737:cytoplasm; --- >prot|F26H11.2a|cod|F26H11.2a|gene|F26H11.2|ann|Nucleosome-remodeling factor subunit NURF301-like. [Source:UniProtKB/Swiss-Prot;Acc:Q6BER5] 1691 2 QQQQQ 5 100 5 1 1253 1257 74 RAEAEKTAKRKLEATRKAQKAKEDEERRRI RSVARIPVPMHSLIPSERNNVPYLGSQQQR GO:0005524:ATP binding; --- --- --- >prot|F26H11.2a|cod|F26H11.2a|gene|F26H11.2|ann|Nucleosome-remodeling factor subunit NURF301-like. [Source:UniProtKB/Swiss-Prot;Acc:Q6BER5] 1691 2 QMVQQQQQ 8 75 5 0.625 1655 1662 97 YVLQGGNSGTPNVNPPKVSSRGGPRGGLTM HNPAHYDMPDDATGFAVSTTTEQVPDEQQ GO:0005524:ATP binding; --- --- --- >prot|C54G6.2|cod|C54G6.2|gene|C54G6.2|ann|The C54G6.2 gene encodes a homolog of human RP2, which when mutated leads to X-linked retinitis pigmentosa 2 (OMIM:312600). [Source: WormBase] 700 1 QQQQQ 5 100 5 1 228 232 32 NNWSPRAPGSTLPVSMETLRLLWEPPLLAE PIVNPMTNIYIWVRTARSLQFFYPTIDVEA --- GO:0006810:transport; GO:0016020:membrane;GO:0016021:integral to membrane; --- >prot|W03C9.7.1|cod|W03C9.7.1|gene|W03C9.7|ann|mex-1 encodes a CCCH-type zinc-finger protein that is required maternally for segregation of P granules, germ cell formation, and somatic cell differentiation in the early embryo. MEX-1 is expressed cytoplasmically in germ line blastomeres, is a component of P granules, and is required for restricting PIE-1 expression and function to these cells. mex-1 mRNA transcripts are also transiently associated with P granules. [Source: WormBase] 494 2 QHQQQQQYQQ 10 80 5 0.5 254 263 51 GEISPARDDEITNPDESSSQVEDLSELHHR RYRRPPFNNFHDMSDSGYSAPRRRLHHQFE --- --- --- --- >prot|W03C9.7.1|cod|W03C9.7.1|gene|W03C9.7|ann|mex-1 encodes a CCCH-type zinc-finger protein that is required maternally for segregation of P granules, germ cell formation, and somatic cell differentiation in the early embryo. MEX-1 is expressed cytoplasmically in germ line blastomeres, is a component of P granules, and is required for restricting PIE-1 expression and function to these cells. mex-1 mRNA transcripts are also transiently associated with P granules. [Source: WormBase] 494 2 QQQQQQQQ 8 100 8 1 299 306 60 PFNNFHDMSDSGYSAPRRRLHHQFEHLGSE TPAPKIVYPSMQVVNIEMATGDGPKRSDNH --- --- --- --- >prot|K08F8.6|cod|K08F8.6|gene|K08F8.6|ann|The let-19 gene encodes a protein related to human TRAP240 (thyroid hormone receptor-associated protein 240, OMIM:300182), a transcriptional co-activation complex subunit conserved in yeast, Drosophila, and humans. LET-19 is required for proper asymmetric cell divisions and cell fusions regulated by LIN-44/Wnt and LIN-17/frizzled, as well as for proper development of secondary vulval cell fates as regulated by Notch signaling. [Source: WormBase] 2862 1 QQQQQQQMQ 9 88.8888888888889 7 0.777777777777778 1419 1427 49 SPNFNQQYNGMGNQLMSPIHQHQFHQQQMV MHRQQMQMQNQNMSQPFQPPTAQMLQMQQN GO:0043169:cation binding; GO:0005975:carbohydrate metabolic process; --- --- >prot|F26H11.2c|cod|F26H11.2c|gene|F26H11.2|ann|Nucleosome-remodeling factor subunit NURF301-like. [Source:UniProtKB/Swiss-Prot;Acc:Q6BER5] 2266 2 QMVQQQQQ 8 75 5 0.625 1655 1662 73 YVLQGGNSGTPNVNPPKVSSRGGPRGGLTM HNPEHRRLLAGRQKQKVTTYRDFMASRGYL GO:0005524:ATP binding; --- --- --- >prot|F32A11.3|cod|F32A11.3|gene|F32A11.3|ann|F32A11.3 [Source:RefSeq_peptide;Acc:NP_496792] 353 1 QIQQQQQ 7 85.7142857142857 5 0.714285714285714 127 133 35 RVKYTTTQQAPASPAPDFTEQQLMAQLQAL PAPDVPVVEPVQQVQQKPKVAPKMLHKMYD --- --- --- --- >prot|F59A2.1a|cod|F59A2.1a|gene|F59A2.1|ann|F59A2.1b [Source:RefSeq_peptide;Acc:NP_871701] 860 1 QQLQQQQQ 8 87.5 5 0.625 98 105 11 NHGKELERLHQIIHTLLARDANPLGSMIPP MLILQRQMEMAHVQAAQAQAHAHAQAQAQA GO:0000166:nucleotide binding;GO:0017111:nucleoside-triphosphatase activity; GO:0030163:protein catabolic process; GO:0016020:membrane; --- >prot|B0511.12|cod|B0511.12|gene|B0511.12|ann|B0511.12 encodes an ortholog of Drosophila PECANEX, and thus may participate in GLP-1/LIN-12 signalling. [Source: WormBase] 1634 1 QQQQQQQASQ 10 80 7 0.7 1267 1276 77 FTFEGFRQLGQNVWNRLRNHFGPSGSTSAH SIVPTPTPVPPVMQITIPSATPSGISSAPG GO:0003677:DNA binding; GO:0006334:nucleosome assembly; GO:0005634:nucleus; --- >prot|C05D11.4|cod|C05D11.4|gene|C05D11.4|ann|let-756 encodes an fibroblast growth factor (FGF)-like ligand that is required for progression through early larval development. LET-756 is expressed from late embryogenesis to adulthood, with a peak of expression in larvae. with EGL-17, LET-756 is redundantly required to activate EGL-15/FGFR, which in turn activates protein degradation in adult muscle cells. homozygotes for partial loss-of-function alleles are small, clear, and scrawny, but viable, while those for a null allele arrest in early larval development. [Source: WormBase] 425 1 QQQQQQQ 7 100 7 1 322 328 75 EDRLRKEEQIREARRQELKSLREEELRRRY ASTQTRYNRPQNPANPYPTYRPLPTRSTVQ --- --- --- --- >prot|F40F9.7a|cod|F40F9.7a|gene|F40F9.7|ann|F40F9.7b [Source:RefSeq_peptide;Acc:NP_001023907] 331 1 QQQQQ 5 100 5 1 47 51 14 PVNYASATQKMSTLASTSSAGASSSTGSSN AAAVIRRRRFSTAKIQPTRIKKVMQSDEDI --- --- --- --- >prot|Y48E1B.14a.1|cod|Y48E1B.14a.1|gene|Y48E1B.14|ann|Y48E1B.14a [Source:RefSeq_peptide;Acc:NP_496844] 971 1 QQQQQ 5 100 5 1 9 13 0 MMNMSDPKQQQQQKIHVGAAVVLLTAIFYA KIHVGAAVVLLTAIFYAADFGFVSILVVIG GO:0005524:ATP binding;GO:0000166:nucleotide binding;GO:0004827:proline-tRNA ligase activity; GO:0006418:tRNA aminoacylation for protein translation;GO:0006412:translation;GO:0006433:prolyl-tRNA aminoacylation; GO:0005737:cytoplasm; --- >prot|T04D1.4|cod|T04D1.4|gene|T04D1.4|ann|T04D1.4 [Source:RefSeq_peptide;Acc:NP_491426] 2967 9 QQQQQQ 6 100 6 1 270 275 9 MRHQYPPHSQQQAPPGYWDGYQGYGGPPPS GGGPVTAPQSMQMAQQEQWGRVGTNDLMNV --- --- --- --- >prot|T04D1.4|cod|T04D1.4|gene|T04D1.4|ann|T04D1.4 [Source:RefSeq_peptide;Acc:NP_491426] 2967 9 QQLQHVQWQQQQQQQQ 16 75 8 0.5 355 370 11 NMQRSASADAEVQQLQHKLAQFQSDHYRYS AAAAAAAAAAAASAGGHHQGPPPPTSSQSN --- --- --- --- >prot|T04D1.4|cod|T04D1.4|gene|T04D1.4|ann|T04D1.4 [Source:RefSeq_peptide;Acc:NP_491426] 2967 9 QQQQQ 5 100 5 1 501 505 16 APQVKMEPEKPSPYQQQYNGMENGSGNPYA HPMYAQYQQQQQQHAQHQQNMSGYPQQQQQ --- --- --- --- >prot|T04D1.4|cod|T04D1.4|gene|T04D1.4|ann|T04D1.4 [Source:RefSeq_peptide;Acc:NP_491426] 2967 9 QQQQQPQ 7 85.7142857142857 5 0.714285714285714 531 537 17 QQQQQHPMYAQYQQQQQQHAQHQQNMSGYP HPHQHQQPASVPMQHHPQQHPSQHQTQPNQ --- --- --- --- >prot|T04D1.4|cod|T04D1.4|gene|T04D1.4|ann|T04D1.4 [Source:RefSeq_peptide;Acc:NP_491426] 2967 9 QQQQQ 5 100 5 1 567 571 19 QHPHQHQQPASVPMQHHPQQHPSQHQTQPN HPSGYGIGVSTAPASMEPSQSVDQSAPPSQ --- --- --- --- >prot|T04D1.4|cod|T04D1.4|gene|T04D1.4|ann|T04D1.4 [Source:RefSeq_peptide;Acc:NP_491426] 2967 9 QQQQQQQQQ 9 100 9 1 2290 2298 77 ADVETVNDSDSEDKKDMAAVAAAQAQFLRL AAAVAASSSASRKASRKRPNNDNDAKMRAM --- --- --- --- >prot|T04D1.4|cod|T04D1.4|gene|T04D1.4|ann|T04D1.4 [Source:RefSeq_peptide;Acc:NP_491426] 2967 9 QQQQQAQ 7 85.7142857142857 5 0.714285714285714 2385 2391 80 MMAASGGQNMTAAQQQALNQMLTMLIAGAV PSTSKGASSSQSSAQANQAAQAQAAAVALA --- --- --- --- >prot|T04D1.4|cod|T04D1.4|gene|T04D1.4|ann|T04D1.4 [Source:RefSeq_peptide;Acc:NP_491426] 2967 9 QQQQQQAQQAQQ 12 83.3333333333333 6 0.5 2510 2521 84 SKPAPQKESTSSATAAAAAASAQAAALAAA AAQQAQSAKTQEELLILRLLELAGVGMQEL --- --- --- --- >prot|T04D1.4|cod|T04D1.4|gene|T04D1.4|ann|T04D1.4 [Source:RefSeq_peptide;Acc:NP_491426] 2967 9 QQQQQQQQ 8 100 8 1 2951 2958 99 LLLTALMQNPAILQSMMLSDPSILAALAAA PSAKKSKHP --- --- --- --- >prot|ZK783.4|cod|ZK783.4|gene|ZK783.4|ann|flt-1 encodes a putative homolog of flectin, an extracellular matrix protein thought to provide a microenvironment of great elasticity. however, FLT-1 protein contains no similarity to other ECM components, instead mostly appearing to be made up of chromatin or DNA-binding domains. FLT-1 also contains a glutamine/asparagine-rich domain, which may mediate epigenetic regulation. [Source: WormBase] 1376 2 QQQQQQQLLQQQ 12 83.3333333333333 7 0.583333333333333 17 28 1 MSDNSSNQFLLLLAAAQQQQQQQLLQQQLA LAKIQKATASSPSKSTNGTSASTSAVPSTS --- --- --- --- >prot|ZK783.4|cod|ZK783.4|gene|ZK783.4|ann|flt-1 encodes a putative homolog of flectin, an extracellular matrix protein thought to provide a microenvironment of great elasticity. however, FLT-1 protein contains no similarity to other ECM components, instead mostly appearing to be made up of chromatin or DNA-binding domains. FLT-1 also contains a glutamine/asparagine-rich domain, which may mediate epigenetic regulation. [Source: WormBase] 1376 2 QMQQKQQQQQ 10 80 5 0.5 232 241 16 SASITSSNNNAANNAASNMMNNVMWQLVAA KDTQKKADQAKKAKELAKQQQKEQDVKNKQ --- --- --- --- >prot|Y51F10.3|cod|Y51F10.3|gene|Y51F10.3|ann|Y51F10.3 [Source:RefSeq_peptide;Acc:NP_740795] 337 1 QQQQQQQ 7 100 7 1 26 32 7 MKISSCLTALFLFLPLLLAQQPLKTQQQQQ KVDASVAKPGLHDILLKTVHDTASYLGFGV GO:0005515:protein binding; --- --- --- >prot|F52C9.8g|cod|F52C9.8g|gene|F52C9.8|ann|Putative RNA exonuclease pqe-1 (PolyQ enhancer protein 1). [Source:UniProtKB/Swiss-Prot;Acc:Q10124] 672 1 QNAQQQQQQ 9 77.7777777777778 6 0.666666666666667 33 41 4 NGGYGSGNSFNLQNYAPIDPMTGIPGFGPS ASAPGTSSGGPSQAVSGASSGASMKTEPVA GO:0008270:zinc ion binding; --- --- --- >prot|F44A6.1a|cod|F44A6.1a|gene|F44A6.1|ann|F44A6.1 encodes two isoforms of a nucleobindin homolog that each contain a calcium-binding EF-hand domain and a glutamine/asparagine-rich domain. F44A6.1 is expressed in muscle (pharyngeal, body wall, and vulval), with weak expression in head and tail neurons and in (mainly posterior) intestinal cells. F44A6.1 has no obvious function in vivo, since it has no obvious phenotype when deleted or inactivated by RNAi (whether in a normal genetic background, or in goa-1 and egl-30 mutant backgrounds). [Source: WormBase] 453 1 QQQQQ 5 100 5 1 416 420 91 QAQQQVHPAQQPIQPVNANPPPVQNAQPPV PPQQPPQQPPQQNLPPVHHEPIQDHTKDPT --- --- --- --- >prot|F08D12.12.1|cod|F08D12.12.1|gene|F08D12.12|ann|F08D12.12 [Source:RefSeq_peptide;Acc:NP_494365] 392 1 QQQQQ 5 100 5 1 6 10 1 MAFGEQQQQQESSKKPERRAGRMKNSEEER ESSKKPERRAGRMKNSEEERARKEPDGKED --- --- --- --- >prot|ZK1098.10a|cod|ZK1098.10a|gene|ZK1098.10|ann|unc-16 encodes a homolog of murine JIP3/JSAP and Drosophila SUNDAY DRIVER that is involved in vesicle transport, and that affects egg laying, locomotion, and defecation and physically interacts with JNK and JNK kinases. UNC-16 is expressed in neurons of the ventral cord, retrovesicular and preanal ganglia, the nerve ring, intestinal cells, seam and hypodermal cells, body wall and head muscle, and pharynx. [Source: WormBase] 1139 1 QQQQQ 5 100 5 1 446 450 39 VLMDRNAYKEKLMELEESIKWTEMQRAKKM NVNQKKSGGIWEFFSSLLGDSVTPPASSRG GO:0005524:ATP binding;GO:0004713:protein tyrosine kinase activity;GO:0004674:protein serine/threonine kinase activity; GO:0006468:protein amino acid phosphorylation; --- --- >prot|B0336.6.2|cod|B0336.6.2|gene|B0336.6|ann|B0336.6 encodes an Abl interactor ortholog, with an SH3 domain, required for embryonic development. mammalian Abl interactors are associated with synaptosomes, growth cone particles, and macropinocytic vesicles, and may regulate Rac-dependent cytoskeletal reorganization and Abl kinase activity. B0336.6's orthologs include human SSH3BP1 (ABI1. OMIM:603050, mutated in acute myeloid leukemia), ABI-2 (OMIM:606442), and NESH (OMIM:606363). B0336.6 binds UNC-53 in two-hybrid screens. [Source: WormBase] 469 1 QQQQQQQMQQQ 11 90.9090909090909 7 0.636363636363636 321 331 68 SSAGGPESPTFPLPPPAMNYTGYVAPGSVV NYGTIRKSTVNRHDLPPPPNSLLTGMSSRM --- GO:0016192:vesicle-mediated transport; --- --- >prot|T05A10.1k|cod|T05A10.1k|gene|T05A10.1|ann|sma-9 encodes, by alternative splicing, at least two large (~2000-residue) protein with at least three N-terminal involucrin domains, seven C-terminal zinc-finger domains, and a glutamine/asparagine-rich domain. SMA-9 is orthologous to human HIVEP1 (OMIM:194540), HIVEP2 (OMIM:143054), and HIVEP3 (OMIM:606649), and to Drosophila SCHNURRI (FBgn0003396). SMA-9 proteins are required for growth to normally large body size. [Source: WormBase] 582 5 QQQQASQQQQQVQHVQQQQQSQQQQQQ 27 77.7777777777778 6 0.222222222222222 63 89 10 HRLNQVQREQLNHQRLLQAQLQTNGPGSVS VASQQNQPQLQMNAQILQALSTPQGQNLVN --- --- --- --- >prot|T05A10.1k|cod|T05A10.1k|gene|T05A10.1|ann|sma-9 encodes, by alternative splicing, at least two large (~2000-residue) protein with at least three N-terminal involucrin domains, seven C-terminal zinc-finger domains, and a glutamine/asparagine-rich domain. SMA-9 is orthologous to human HIVEP1 (OMIM:194540), HIVEP2 (OMIM:143054), and HIVEP3 (OMIM:606649), and to Drosophila SCHNURRI (FBgn0003396). SMA-9 proteins are required for growth to normally large body size. [Source: WormBase] 582 5 QQAQQQQQGQSQ 12 75 5 0.416666666666667 406 417 69 MQAQLQQQLLLQQQQAQAQQAQQAQQAQLA NRTVSQALQYIQSMQLQQRADGTPNAIVEK --- --- --- --- >prot|K07C11.1|cod|K07C11.1|gene|K07C11.1|ann|PAX (Paired box) transcription factor family member (pax-1) [Source:RefSeq_peptide;Acc:NP_505120] 257 1 QQQQQ 5 100 5 1 210 214 81 ISRILRNKNGGNSSSSSSSQLRYIRDQLAE HLQQHQYMEYNNNELNQISGNLDYQVSSSN --- --- --- --- >prot|Y53G8AR.9|cod|Y53G8AR.9|gene|Y53G8AR.9|ann|Y53G8AR.9 [Source:RefSeq_peptide;Acc:NP_497690] 315 1 QQQQQ 5 100 5 1 50 54 15 SHHDAAPQQQQNNMSHQQQPQQQQHNEHNK RDDVCRDFLKNICNRGSRCKFYHPSEAPPI --- --- --- --- >prot|K08A8.3|cod|K08A8.3|gene|K08A8.3|ann|coh-1 encodes a RAD21 homolog that affects embryonic viability and is believed to affect cohesion of sister chromatids in somatic cells. expressed in the distal tip cells of the gonad, embryonic, and somatic cells [Source: WormBase] 652 1 QQQQQ 5 100 5 1 483 487 74 LVVTKHDDVDEKNEWIKNALGLREIGEEEL EMDMHVQDDSSYVDDFDEVPPLDFDQLDMM --- --- --- --- >prot|K10G6.3|cod|K10G6.3|gene|K10G6.3|ann|sea-2 is an autosomal signal element gene, whose protein product contains four C2H2 zinc finger domains and three involucrin repeats embedded in extensive regions of low-complexity (e.g., glutamine/asparagine-rich) protein sequence. sea-2 has no obvious biological function in mass RNAi assays. [Source: WormBase] 1838 3 QQQQQ 5 100 5 1 877 881 47 ALRAQQHQQKMDQQIQIQFQQQQQQRFQHH AGRIPPRPPNPILNQVQNPPQQVQHNQHQN GO:0005524:ATP binding;GO:0004674:protein serine/threonine kinase activity; GO:0006468:protein amino acid phosphorylation; --- --- >prot|K10G6.3|cod|K10G6.3|gene|K10G6.3|ann|sea-2 is an autosomal signal element gene, whose protein product contains four C2H2 zinc finger domains and three involucrin repeats embedded in extensive regions of low-complexity (e.g., glutamine/asparagine-rich) protein sequence. sea-2 has no obvious biological function in mass RNAi assays. [Source: WormBase] 1838 3 QQQQQ 5 100 5 1 989 993 53 RSSEGLVAVTSTPLPPIQLPQRSQAPAPSR PPVAYQVQFNGRPLPPMQLPPLQNPHNQQQ GO:0005524:ATP binding;GO:0004674:protein serine/threonine kinase activity; GO:0006468:protein amino acid phosphorylation; --- --- >prot|K10G6.3|cod|K10G6.3|gene|K10G6.3|ann|sea-2 is an autosomal signal element gene, whose protein product contains four C2H2 zinc finger domains and three involucrin repeats embedded in extensive regions of low-complexity (e.g., glutamine/asparagine-rich) protein sequence. sea-2 has no obvious biological function in mass RNAi assays. [Source: WormBase] 1838 3 QQQQQ 5 100 5 1 1474 1478 80 SLASPGEQFGYQQYSQHPQQHPQQHPQQHP VWNPNYEFQGYMQQQHPPMPVSQQFQQPLL GO:0005524:ATP binding;GO:0004674:protein serine/threonine kinase activity; GO:0006468:protein amino acid phosphorylation; --- --- >prot|R06C1.6|cod|R06C1.6|gene|R06C1.6|ann|R06C1.6 [Source:RefSeq_peptide;Acc:NP_493030] 432 1 QQQQQHEQQ 9 77.7777777777778 5 0.555555555555556 56 64 12 GAEAMSFGRGISNDLPTAYVTSTPLPLAKA LHHLPGYHSAGQSRVMSEEENEREKHAKIS GO:0005506:iron ion binding; GO:0009072:aromatic amino acid family metabolic process; --- --- >prot|W02C12.3b|cod|W02C12.3b|gene|W02C12.3|ann|W02C12.3 is orthologous to the human gene TRANSCRIPTION FACTOR BINDING TO IGHM ENHANCER 3 (TFE3. OMIM:314310), which when mutated leads to disease [Source: WormBase] 499 1 QQQQQPQQAQQQ 12 83.3333333333333 5 0.416666666666667 28 39 5 MIRQLNSPGGGGGLGLNNPRAQQPPGAQQQ FYDDEPYQANASQFRFGAGKSMEQRRETGN GO:0008533:astacin activity;GO:0008237:metallopeptidase activity;GO:0008270:zinc ion binding; --- --- --- >prot|T08H4.3|cod|T08H4.3|gene|T08H4.3|ann|ast-1 encodes a novel ETS-box transcription factor. AST-1 is required for the proper navigation of some interneuron axons to their targets, for differentiation of the ventral cord pioneer neuron AVG, and for pharyngeal morphogenesis. AST-1 is transiently expressed in many head neurons late in their differentiation and axon outgrowth, and in a few pharyngeal cells. AST-1 is at first nuclear, but then relocates to spots in cell bodies and even neuronal processes. hypomorphic ast-1 mutants have axons extending laterally, and crossing over from the right axon tract to the left axon bundle. null ast-1(hd92) mutants are inviable, failing to attach a working pharynx to their cuticle during development and then starving as L1 larvae. behaviorally, hypomorphic ast-1 animals are at least superficially normal, indicating that the ventral nerve cord can tolerate at least some miswiring. AST-1 regulates odr-2 expression, while ast-1 expression is itself regulated by lin-11. [Source: WormBase] 377 1 QEQQQQQQQQ 10 90 8 0.8 41 50 10 PTVASADLAIVGGRSSDEDVIKYSAIQTIK SNTALPSYNFPFFNGMQNDFPPNRMLYNDN GO:0005515:protein binding; --- --- --- >prot|Y106G6H.2c|cod|Y106G6H.2c|gene|Y106G6H.2|ann|pab-1 encodes a polyadenylate-binding protein (i.e., poly(A)-binding protein, or PAB). while not extensively characterized, PAB-1 has been successfully used as an epitope-tagged transgenic reagent for tissue-specific isolation of mRNAs. [Source: WormBase] 586 1 QQQQQQ 6 100 6 1 472 477 80 NQVAQGGVRMQGPPRTQNPGVQQQNVPRPP RPAPTGPKAPPQPYQAYQQRPQGIVIGGQE GO:0000287:magnesium ion binding;GO:0003684:damaged DNA binding;GO:0016779:nucleotidyltransferase activity; --- GO:0005622:intracellular; --- >prot|C09E7.2|cod|C09E7.2|gene|C09E7.2|ann|PQN-10 encodes an unfamiliar protein, with limited similarity to F27B3.6, that has a glutamine/asparagine-rich domain. [Source: WormBase] 408 1 QQQQQ 5 100 5 1 145 149 35 GSNGMFGQNAFGTGFNNNLFGASTNGLLGG LTTNAFQNSQPMSLNNGNTMKAYGRRSTAQ GO:0008890:glycine C-acetyltransferase activity; --- --- --- >prot|Y43F8C.6|cod|Y43F8C.6|gene|Y43F8C.6|ann|Y43F8C.6 [Source:RefSeq_peptide;Acc:NP_507806] 422 1 QQQQQ 5 100 5 1 9 13 2 MNSRNYENQQQQQGGHVPPVASNTVTIGTS GGHVPPVASNTVTIGTSANSQVRIGPSTQI --- --- --- --- >prot|Y47D3A.6a|cod|Y47D3A.6a|gene|Y47D3A.6|ann|tra-1 encodes Zn2+-finger-containing proteins that are the sole C. elegans members of the GLI transcription factor family. during development, tra-1 functions cell autonomously as the terminal regulator of the sex determination pathway and positively regulates all aspects of hermaphrodite somatic sexual differentiation. in addition, tra-1 activity is required for proper development of the male somatic gonad and for sustained spermatogenesis in both sexes. in regulating sex-specific development, TRA-1 functions, in part, by repressing transcription of mab-3 and egl-1 in the intestine and HSN neurons, respectively. TRA-1 is expressed in hermaphrodites and males and localizes to both the nucleus and cytoplasm of many different cell types. expression of C-terminally truncated TRA-1 isoforms is much higher in hermaphrodites than males, due to sex-specific proteolysis that results in the presence of feminizing TRA-1 isoforms in hermaphrodites. [Source: WormBase] 1109 1 QQQQQQ 6 100 6 1 598 603 53 TAPAPLVPAPVPASPVFDELREQMREVEPL EPMDQDLQDIRVDGDSDDEDEEEPRTPSGA GO:0005515:protein binding;GO:0008270:zinc ion binding; --- --- --- >prot|Y39A1B.3|cod|Y39A1B.3|gene|Y39A1B.3|ann|dpy-28 encodes a non-SMC condensin subunit homolog, similar to XCAP-D2 in Xenopus, Cnd1 in S. pombe, and Ycs4p in S. cerevisiae, that is required for negative, chromosome-wide regulation of X-chromosomal genes in XX but not XO animals (dosage compensation), and for some undetermined aspect of body morphogenesis. DPY-28 is part of a multiprotein 'dosage compensation' complex with DPY-26, DPY-27 and MIX-1. [Source: WormBase] 1499 1 QQQQQQ 6 100 6 1 29 34 1 MPRKQRVVTTPSPPTSDEDEDMDFGSTSQQ PTRNNDGLSGFKSITEIIAEADNNIPSEQI --- --- --- --- >prot|K03H1.5|cod|K03H1.5|gene|K03H1.5|ann|Uncharacterized protein K03H1.5 precursor. [Source:UniProtKB/Swiss-Prot;Acc:P34501] 1385 1 QLLQQQQQ 8 75 5 0.625 278 285 20 AQSAANQQFSNPSQYSQNLNAYSQNQQYNT IYGKRKKRQMPGRVSQPGMVVDPWLLDNIT --- --- --- --- >prot|Y40B1A.4|cod|Y40B1A.4|gene|Y40B1A.4|ann|Specificity Protein) Transcription Factor family member (sptf-3) [Source:RefSeq_peptide;Acc:NP_493353] 412 5 QQQQPHQQMQQQQQQQ 16 81.25 7 0.4375 6 21 1 MSKSGQQQQPHQQMQQQQQQQGKMMVVHHQ GKMMVVHHQRTTTPDGSQVYLLQPSQSHPQ --- --- --- --- >prot|Y40B1A.4|cod|Y40B1A.4|gene|Y40B1A.4|ann|Specificity Protein) Transcription Factor family member (sptf-3) [Source:RefSeq_peptide;Acc:NP_493353] 412 5 QQQQQQ 6 100 6 1 80 85 19 PQQRQVQFIPIQVAQGEKKPQTVMMNQMMG PSSSNQQSQQQVQQQQQQVHQVQQVQQHQM --- --- --- --- >prot|Y40B1A.4|cod|Y40B1A.4|gene|Y40B1A.4|ann|Specificity Protein) Transcription Factor family member (sptf-3) [Source:RefSeq_peptide;Acc:NP_493353] 412 5 QQSQQQVQQQQQQ 13 84.6153846153846 6 0.461538461538462 91 103 22 QVAQGEKKPQTVMMNQMMGQQQQQQPSSSN VHQVQQVQQHQMQQQNQTVQQQHLMMETID --- --- --- --- >prot|Y40B1A.4|cod|Y40B1A.4|gene|Y40B1A.4|ann|Specificity Protein) Transcription Factor family member (sptf-3) [Source:RefSeq_peptide;Acc:NP_493353] 412 5 QQQQQQQQQQQQ 12 100 12 1 148 159 35 QNQTVQQQHLMMETIDQVGSGIIGNSNGNN RRDPIPIAPAGMVSGQRMQQQQQQPQQQQQ --- --- --- --- >prot|Y40B1A.4|cod|Y40B1A.4|gene|Y40B1A.4|ann|Specificity Protein) Transcription Factor family member (sptf-3) [Source:RefSeq_peptide;Acc:NP_493353] 412 5 QRMQQQQQQPQQQQQ 15 80 6 0.4 175 189 42 GNNQQQQQQQQQQQQRRDPIPIAPAGMVSG HNNNNTGASTSNGGVNAAPVMPVMGGQQRI --- --- --- --- >prot|C24H11.7|cod|C24H11.7|gene|C24H11.7|ann|GBF1(Golgi-specific Brefeldin-A-resistant Factor 1) homolog family member (gbf-1) [Source:RefSeq_peptide;Acc:NP_499522] 1975 2 QQQQQQQQQ 9 100 9 1 1843 1851 93 QHSEHQQYEQYRQQQAAAAQQYQQYNQNYP YAYSPEHAAYYQQQYAHQQQQYAEHYANQY GO:0016855:racemase and epimerase activity, acting on amino acids and derivatives; GO:0007186:G-protein coupled receptor protein signaling pathway;GO:0008152:metabolic process; GO:0016021:integral to membrane; --- >prot|C24H11.7|cod|C24H11.7|gene|C24H11.7|ann|GBF1(Golgi-specific Brefeldin-A-resistant Factor 1) homolog family member (gbf-1) [Source:RefSeq_peptide;Acc:NP_499522] 1975 2 QYQHYQQQQQQQQQ 14 78.5714285714286 9 0.642857142857143 1880 1893 95 QQYAYSPEHAAYYQQQYAHQQQQYAEHYAN HPVNPTSPSVHGQYSVANPLPLPAHPAYHP GO:0016855:racemase and epimerase activity, acting on amino acids and derivatives; GO:0007186:G-protein coupled receptor protein signaling pathway;GO:0008152:metabolic process; GO:0016021:integral to membrane; --- >prot|M110.5b|cod|M110.5b|gene|M110.5|ann|dab-1 encodes an ortholog of the cytoplasmic adaptor protein DISABLED, required for normal molting and meiotic arrest. DAB-1 is also required for EGL-17 secretion from vulval cells, and thus indirectly for normal sex myoblast (SM) migration and egg-laying. DAB-1 contains a conserved PTB domain and signals that confer localization to Golgi-proximal vesicles, and DAB-1 localizes to vesicular structures in vivo. dab-1 is expressed in ventral precursor cells, and DAB-1 prevents EGL-17 protein accumulation in them. dab-1 is also expressed in other cells (anchor cell, sheath cells, etc.) but has no obvious function in them. DAB-1 binds the cytoplasmic domains of either LRP-1 or LRP-2 in yeast two-hybrid experiments. dab-1(gk291) and dab-1(RNAi) animals have similar defects in molting, EGL-17 secretion from VPCs, SM migration, and egg-laying. dab-1(RNAi) does not enhance the SM phenotypes of lrp-1(RNAi) or lrp-2(RNAi), suggesting that these genes act in concert to promote normal EGL-17 secretion and SM migration. in vitro, DAB-1 binds to the ear domains of APT-4 (strongly) and of APT-1 and APT-9 (weakly). genetically, dab-1(RNAi) functions as part of the vab-1 pathway in oocytes inhibiting meiotic maturation, and DAB-1 is found in oocyte cytoplasm. [Source: WormBase] 492 1 QQQQQQQ 7 100 7 1 305 311 61 QQMQMPMVQIPQQSHQNWPTSGAGSFDAWG MHHAHSTPAFGTNGFSDTNPFASAFNTQAR --- --- --- --- >prot|Y43H11AL.3|cod|Y43H11AL.3|gene|Y43H11AL.3|ann|pqn-85 encodes an ortholog of budding yeast Scc2p, Drosophila NIPPED-B, and human NIPBL (OMIM:608667, mutated in Cornelia de Lange syndrome) that is required for resistance to double-stranded DNA breakage. PQN-85 is also required, with MAU-2 and SCC-3, for normal chromosome segregation and embryonic viability. pqn-85(RNAi) induces hypersensitivity to double-stranded breaks in DNA (manifested by abnormal sterility induced by ionizing radiation, cisplatin, or camptothecin). pqn-85(RNAi) of early embryos produces lagging of anaphase chromosomes and 100% embryonic lethality. pqn-85(RNAi) is phenotypically enhanced by joint RNAi with mau-2, and joint pqn-85/scc-3(RNAi) grossly deranges chromosomal segregation in early embryos. by orthology with NIPPED-B, PQN-85 might also enable regulatory interactions between promoters and distant enhancers by antagonizing SCC-3. [Source: WormBase] 2203 4 QAQQQQQQQ 9 88.8888888888889 7 0.777777777777778 73 81 3 ATGQYNPMLLQQQYLNFGFGMNYNNQLFDF YLMQQQQQQQQLHHQQQQQHQNIAQPQAQH --- --- --- --- >prot|Y43H11AL.3|cod|Y43H11AL.3|gene|Y43H11AL.3|ann|pqn-85 encodes an ortholog of budding yeast Scc2p, Drosophila NIPPED-B, and human NIPBL (OMIM:608667, mutated in Cornelia de Lange syndrome) that is required for resistance to double-stranded DNA breakage. PQN-85 is also required, with MAU-2 and SCC-3, for normal chromosome segregation and embryonic viability. pqn-85(RNAi) induces hypersensitivity to double-stranded breaks in DNA (manifested by abnormal sterility induced by ionizing radiation, cisplatin, or camptothecin). pqn-85(RNAi) of early embryos produces lagging of anaphase chromosomes and 100% embryonic lethality. pqn-85(RNAi) is phenotypically enhanced by joint RNAi with mau-2, and joint pqn-85/scc-3(RNAi) grossly deranges chromosomal segregation in early embryos. by orthology with NIPPED-B, PQN-85 might also enable regulatory interactions between promoters and distant enhancers by antagonizing SCC-3. [Source: WormBase] 2203 4 QAQQQQQQQYLMQQQQQQQQ 20 80 8 0.4 73 92 3 ATGQYNPMLLQQQYLNFGFGMNYNNQLFDF LHHQQQQQHQNIAQPQAQHHQMNMFTQHQM --- --- --- --- >prot|Y43H11AL.3|cod|Y43H11AL.3|gene|Y43H11AL.3|ann|pqn-85 encodes an ortholog of budding yeast Scc2p, Drosophila NIPPED-B, and human NIPBL (OMIM:608667, mutated in Cornelia de Lange syndrome) that is required for resistance to double-stranded DNA breakage. PQN-85 is also required, with MAU-2 and SCC-3, for normal chromosome segregation and embryonic viability. pqn-85(RNAi) induces hypersensitivity to double-stranded breaks in DNA (manifested by abnormal sterility induced by ionizing radiation, cisplatin, or camptothecin). pqn-85(RNAi) of early embryos produces lagging of anaphase chromosomes and 100% embryonic lethality. pqn-85(RNAi) is phenotypically enhanced by joint RNAi with mau-2, and joint pqn-85/scc-3(RNAi) grossly deranges chromosomal segregation in early embryos. by orthology with NIPPED-B, PQN-85 might also enable regulatory interactions between promoters and distant enhancers by antagonizing SCC-3. [Source: WormBase] 2203 4 QQQQQQQQQQPVQQIQRQQ 19 78.9473684210526 10 0.526315789473684 127 145 5 QQQQHQNIAQPQAQHHQMNMFTQHQMLQLM PIAQPIPQHTIPPSTSNQFQQQIQSAASSI --- --- --- --- >prot|Y43H11AL.3|cod|Y43H11AL.3|gene|Y43H11AL.3|ann|pqn-85 encodes an ortholog of budding yeast Scc2p, Drosophila NIPPED-B, and human NIPBL (OMIM:608667, mutated in Cornelia de Lange syndrome) that is required for resistance to double-stranded DNA breakage. PQN-85 is also required, with MAU-2 and SCC-3, for normal chromosome segregation and embryonic viability. pqn-85(RNAi) induces hypersensitivity to double-stranded breaks in DNA (manifested by abnormal sterility induced by ionizing radiation, cisplatin, or camptothecin). pqn-85(RNAi) of early embryos produces lagging of anaphase chromosomes and 100% embryonic lethality. pqn-85(RNAi) is phenotypically enhanced by joint RNAi with mau-2, and joint pqn-85/scc-3(RNAi) grossly deranges chromosomal segregation in early embryos. by orthology with NIPPED-B, PQN-85 might also enable regulatory interactions between promoters and distant enhancers by antagonizing SCC-3. [Source: WormBase] 2203 4 QQQQQ 5 100 5 1 1775 1779 80 GHFCAQHSTYLTKRQLTNTYLEILNAANSP RILVLQNLEMFLQCEEQKLAASHDKWDENK --- --- --- --- >prot|Y67H2A.10|cod|Y67H2A.10|gene|Y67H2A.10|ann|Y67H2A.10 encodes a divergent ortholog of S. cerevisiae SFP1p. in yeast, and probably other eukaryotes, SFP1p is a stress-modulated transcription factor. Y67H2A.10's orthology is invisible in its primary sequence alone, but is detectable by examining the Brugia malayi ortholog of SFP1p, 14538.m00477. [Source: WormBase] 608 3 QQQQQQQQQQGMQMQQAQ 18 77.7777777777778 10 0.555555555555556 419 436 68 VLQMQMQHQKRMKQMQEQQAAQQAAAAAAA FSSSPINQMGQQGQQQQQMGPLPSLQHPQQ --- --- --- --- >prot|Y67H2A.10|cod|Y67H2A.10|gene|Y67H2A.10|ann|Y67H2A.10 encodes a divergent ortholog of S. cerevisiae SFP1p. in yeast, and probably other eukaryotes, SFP1p is a stress-modulated transcription factor. Y67H2A.10's orthology is invisible in its primary sequence alone, but is detectable by examining the Brugia malayi ortholog of SFP1p, 14538.m00477. [Source: WormBase] 608 3 QQGQQQQQ 8 87.5 5 0.625 447 454 73 AAQQQQQQQQQQGMQMQQAQFSSSPINQMG MGPLPSLQHPQQQQQQQQYHQMPPQPQHSP --- --- --- --- >prot|Y67H2A.10|cod|Y67H2A.10|gene|Y67H2A.10|ann|Y67H2A.10 encodes a divergent ortholog of S. cerevisiae SFP1p. in yeast, and probably other eukaryotes, SFP1p is a stress-modulated transcription factor. Y67H2A.10's orthology is invisible in its primary sequence alone, but is detectable by examining the Brugia malayi ortholog of SFP1p, 14538.m00477. [Source: WormBase] 608 3 QQQQQQQQYQQQHQQSPQ 18 77.7777777777778 8 0.444444444444444 504 521 82 HQMPPQPQHSPYPQQQQMHHQMVQHSPHHY FPSYQQSPQQQQAPPPQRSPIPLSQSLPPL --- --- --- --- >prot|F44B9.6|cod|F44B9.6|gene|F44B9.6|ann|Protein lin-36 (Abnormal cell lineage protein 36). [Source:UniProtKB/Swiss-Prot;Acc:P34427] 962 1 QQQQQQQQQQQEQFPGQ 17 76.4705882352941 11 0.647058823529412 939 955 97 FGERTEDYQIFYSNDGAQVLTKKDPKWREL GSSDSQQ --- --- --- --- >prot|F43B10.2b|cod|F43B10.2b|gene|F43B10.2|ann|Temporarily Assigned Gene name family member (tag-343) [Source:RefSeq_peptide;Acc:NP_001041251] 774 1 QQQQQ 5 100 5 1 601 605 77 SSPILVRVQLSSKSPDSVRRQVQPQPQPQP YEAYGEADYVSRNLPLGVTEETTTTTTTTR --- --- --- --- >prot|C17D12.2|cod|C17D12.2|gene|C17D12.2|ann|unc-75 encodes an RNA-binding protein with two N-terminal RNA recognition motifs (RRMs), a glutamine/asparagine-rich linker domain, and a third C-terminal RRM. UNC-75 is orthologous to mammalian CELF/BrunoL proteins that control pre-mRNA splicing. unc-75 is expressed in all neurons and in neurosecretory gland cells, and is required for normal modulation of GABA- and acetylcholine-mediated neurotransmission. UNC-75 protein is found with other RRM proteins in dynamic nuclear speckles, consistent with a role in alternative mRNA splicing. unc-75 mutations can be rescued in vivo by a human unc-75 transgene, but not by exc-7 or W02D3.11, indicating that UNC-75 acts on evolutionarily conserved but highly specific pre-mRNA substrates. both UNC-75 and EXC-7 are required in parallel for normal cholinergic neurotransmission. [Source: WormBase] 514 1 QQTQQQQQQQQQ 12 91.6666666666667 9 0.75 293 304 57 LQQQTTDPLHVLQLQAAAAAAQAAANPVLS LAAQLQLQSAAAQNPHYALAAQALAQQQAA --- --- --- --- >prot|F52G2.1a|cod|F52G2.1a|gene|F52G2.1|ann|dcap-2 encodes an mRNA decapping enzyme that is a member of the NUDIX hydrolase (NUcleoside Diphosphate linked to some moiety X) family of enzymes. dcap-2 exhibits sequence- and context-dependent hydrolysis of mRNA caps in vitro, but RNAi experiments indicate that this activity is not essential for embryonic development. DCAP-2 localizes to cytoplasmic mRNA processing bodies and to P granules throughout embryonic development. [Source: WormBase] 770 1 QQNYQQQQQQ 10 80 6 0.6 118 127 15 QAENARISQTKRPRQVSTSKGSSRNTTAPE YKGPRIPTDILDELEFRFISNMVECEINDN GO:0008289:lipid binding;GO:0004792:thiosulfate sulfurtransferase activity; GO:0006810:transport;GO:0008272:sulfate transport; --- --- >prot|Y46G5A.1a|cod|Y46G5A.1a|gene|Y46G5A.1|ann|Y46G5A.1a [Source:RefSeq_peptide;Acc:NP_001022434] 1085 1 QQQQQQQQQAQ 11 90.9090909090909 9 0.818181818181818 4 14 0 MNDQQQQQQQQQAQRERAGTVYYDAQQNFG RERAGTVYYDAQQNFGTPPKSSDHQKNNMS --- GO:0006412:translation; GO:0005622:intracellular;GO:0005840:ribosome; --- >prot|F19B2.6|cod|F19B2.6|gene|F19B2.6|ann|F19B2.6 [Source:RefSeq_peptide;Acc:NP_507885] 807 1 QQQQQPKQ 8 75 5 0.625 68 75 8 NQQIQGIEQTGEPNGDNQPPQLVIDQLSYD NCFDTHGNMDDNRGLYNLPQGAENGSGHLV --- --- --- --- >prot|F02E9.4a|cod|F02E9.4a|gene|F02E9.4|ann|pqn-28 encodes an ortholog of the SIN3 family of histone deacetylase subunits, which also has a glutamine/asparagine-rich domain, possibly involved in epigenetic regulation. pqn-28 has no obvious phenotype in mass RNAi screens. on the basis of its homology, PQN-28, when activated by promoter-specific transcription factors, is expected to work in conjunction with other histone deacetylase components to induce chromatin silencing. PQN-28 may also silence genes by colocating to them with the O-GlcNAc transferase homolog OGT-1. [Source: WormBase] 1505 1 QQSQHQQQHQNQQQQQ 16 75 5 0.3125 35 50 2 PPGGGGGNNGGDQSQQQPTNNATLFLLQMI LELQIRDQERILIEQQRMQHQQQQNQLLQG --- --- --- --- >prot|F59B10.1|cod|F59B10.1|gene|F59B10.1|ann|pqn-47 encodes a protein with a glutamine/asparagine-rich domain, homologous to human C11orf9 and Drosophila CG3328, that is required for locomotion, vulval development, full body size, cuticular integrity, and general health in mass RNAi assays. pqn-47(cxP5915) homozygotes are sluggish. [Source: WormBase] 931 1 QQQQQQ 6 100 6 1 53 58 5 QYLTQDTDEDDGSMVSPTSSADSMHQNLGV MLQAQQRQNQNGIFQPRRFPESPAMTDPCG --- --- --- --- >prot|Y92H12A.5|cod|Y92H12A.5|gene|Y92H12A.5|ann|Y92H12A.5 [Source:RefSeq_peptide;Acc:NP_490861] 1375 1 QQQQQKQQ 8 87.5 5 0.625 243 250 17 LLTSTDAKLIKSRLVPMLQKYHLPGSNKEK KPQESDTAVKFLNQLLIQLNSQDPPSDLQS GO:0030528:transcription regulator activity; GO:0045449:regulation of transcription; --- --- >prot|F48C1.4|cod|F48C1.4|gene|F48C1.4|ann|F48C1.4 [Source:RefSeq_peptide;Acc:NP_491563] 104 1 QQQQQQPQQQQ 11 90.9090909090909 6 0.545454545454545 35 45 33 DNAVGTETNEDKPTTSNAVTAENPSRGDES KRVKPGHHHFLRVLFCNKIRKSLIPLCLFI --- --- --- --- >prot|C30A5.3.1|cod|C30A5.3.1|gene|C30A5.3|ann|Uncharacterized protein C30A5.3. [Source:UniProtKB/Swiss-Prot;Acc:P34349] 223 1 QQQQQQ 6 100 6 1 214 219 95 ETHLCKRFTTYVSKYNLMQQEHLIVPILPN TTVQ --- --- GO:0016020:membrane; --- >prot|T01D1.2b|cod|T01D1.2b|gene|T01D1.2|ann|etr-1 encodes a muscle-specific ELAV-type RNA-binding protein, whose homologs include Drosophila ELAV and human CUG-BINDING PROTEIN (CUGBP1. OMIM:601074). etr-1 function is required for embryonic muscle development, which suggests that ETR-1's homology to CUG-BP (implicated in myotonic dystrophy) might reflect conserved roles in development. [Source: WormBase] 352 1 QQHQQQLSQQQQQQQHPQQQ 20 75 7 0.35 117 136 33 SSEKPRHQALMTSPAPTATSSTSSSASHHH GLGNPLLGNPAMAAQNQFDAITMAQIAHQQ GO:0004713:protein tyrosine kinase activity;GO:0005524:ATP binding;GO:0004674:protein serine/threonine kinase activity; GO:0007049:cell cycle;GO:0009790:embryo development;GO:0006468:protein amino acid phosphorylation; GO:0005634:nucleus; --- >prot|Y61A9LA.3c|cod|Y61A9LA.3c|gene|Y61A9LA.3|ann|Y61A9LA.3b [Source:RefSeq_peptide;Acc:NP_504240] 726 1 QHQQQQQQ 8 87.5 6 0.75 600 607 82 SLLDSVTMGMKVAAVAQMSQAQNPIQGGLF PMMSGGGGFVSGVQIHHQAFPQPQQLNTTP --- --- --- --- >prot|Y53C10A.12.1|cod|Y53C10A.12.1|gene|Y53C10A.12|ann|hsf-1 encodes the C. elegans heat-shock transcription factor ortholog. HSF-1 functions as a transcriptional regulator of stress-induced gene expression whose activity is required for heat-shock and proteotoxicity response, larval development, innate immunity, and regulation of adult lifespan. [Source: WormBase] 671 1 QIQQNQQQQQQ 11 81.8181818181818 6 0.545454545454545 7 17 1 MQPTGNQIQQNQQQQQQLIMRVPKQEVSVS LIMRVPKQEVSVSGAARRYVQQAPPNRPPR --- --- --- --- >prot|C04A2.3a|cod|C04A2.3a|gene|C04A2.3|ann|egl-27 encodes a homolog of human MTA1, part of an ATP-dependent complex with nucleosome remodelling and histone deacetylation activities that may promote tumor metastasis. in conjunction with its paralog egr-1, egl-27 is required for proper organization in all parts of the embryo, and for the embryonic expression of hlh-8. [Source: WormBase] 1129 3 QQQQQ 5 100 5 1 903 907 79 QMALQQQLEAHQVQFQLMMAHQHQQKMIAE RHAAAQQLREREQREQRERERERQHQQQAQ GO:0004767:sphingomyelin phosphodiesterase activity; --- GO:0005576:extracellular region; --- >prot|D1007.13a|cod|D1007.13a|gene|D1007.13|ann|D1007.13b [Source:RefSeq_peptide;Acc:NP_001076600] 142 1 QQAFQQQQQ 9 77.7777777777778 5 0.555555555555556 74 82 52 TYPPSTFAPSAYPTSSSWGSTHPPEDLPTV SYGTVQPQVSLAQSLIGNSNGFGGLPGLLP --- GO:0007264:small GTPase mediated signal transduction;GO:0015031:protein transport; GO:0005622:intracellular; --- >prot|F55A8.1.2|cod|F55A8.1.2|gene|F55A8.1|ann|egl-18 encodes a member of the GATA-family of transcription factors that affects cell migration, cell fate specification. expressed in the head, in hypodermal seam cells, VC neurons, and vulval precursor cells. [Source: WormBase] 376 1 QQQQQQQQHHQ 11 81.8181818181818 8 0.727272727272727 150 160 39 PDFSNLMNGFMFDPLNMSNPNGMMQLLSMV HIENQQSVSPPQSKSVKIEDPMDQDVKQEE GO:0004519:endonuclease activity; GO:0006281:DNA repair; GO:0005622:intracellular; --- >prot|F26H11.2b|cod|F26H11.2b|gene|F26H11.2|ann|Nucleosome-remodeling factor subunit NURF301-like. [Source:UniProtKB/Swiss-Prot;Acc:Q6BER5] 1693 2 QMVQQQQQ 8 75 5 0.625 1655 1662 97 YVLQGGNSGTPNVNPPKVSSRGGPRGGLTM HNPFQAHYDMPDDATGFAVSTTTEQVPDEQ GO:0005524:ATP binding; --- --- --- >prot|F41G3.3|cod|F41G3.3|gene|F41G3.3|ann|F41G3.3 [Source:RefSeq_peptide;Acc:NP_495382] 577 1 QQQQQQQ 7 100 7 1 287 293 49 INNLKSGGAEKQEDTIPRNRVSTNPFMRAN NHNATRFENNKNSSKNVAEVVEKMNNGDWP --- --- --- --- >prot|F26G5.9|cod|F26G5.9|gene|F26G5.9|ann|tam-1 encodes a broadly expressed nuclear protein with RING finger, B-box, and glutamine/asparagine-rich domains that promotes signalling in the class B synthetic-multivulva gene pathway (which includes the lin-35/RB gene), and also promotes the activity of genes in multicopy transgenic arrays. the normal role of TAM-1's class B activity is presumably to inhibit RAS pathway activity in vulval development, while TAM-1's effect on transgenes may be through changes in the acetylation state of histones in chromatin. [Source: WormBase] 944 3 QQQQQQ 6 100 6 1 537 542 56 IMHGNMQIAFQQHMHNNANVPMPPQMPAHP RHPNEGQQFQQGPPPPPPQRIQNHQQQMQQ GO:0016651:oxidoreductase activity, acting on NADH or NADPH; --- --- --- >prot|F26G5.9|cod|F26G5.9|gene|F26G5.9|ann|tam-1 encodes a broadly expressed nuclear protein with RING finger, B-box, and glutamine/asparagine-rich domains that promotes signalling in the class B synthetic-multivulva gene pathway (which includes the lin-35/RB gene), and also promotes the activity of genes in multicopy transgenic arrays. the normal role of TAM-1's class B activity is presumably to inhibit RAS pathway activity in vulval development, while TAM-1's effect on transgenes may be through changes in the acetylation state of histones in chromatin. [Source: WormBase] 944 3 QQLQVQQQQQPQ 12 75 5 0.416666666666667 575 586 60 PNEGQQFQQGPPPPPPQRIQNHQQQMQQYH PRAQPFRPPIQQQQQLQQIDLQAMNDRQFQ GO:0016651:oxidoreductase activity, acting on NADH or NADPH; --- --- --- >prot|F26G5.9|cod|F26G5.9|gene|F26G5.9|ann|tam-1 encodes a broadly expressed nuclear protein with RING finger, B-box, and glutamine/asparagine-rich domains that promotes signalling in the class B synthetic-multivulva gene pathway (which includes the lin-35/RB gene), and also promotes the activity of genes in multicopy transgenic arrays. the normal role of TAM-1's class B activity is presumably to inhibit RAS pathway activity in vulval development, while TAM-1's effect on transgenes may be through changes in the acetylation state of histones in chromatin. [Source: WormBase] 944 3 QQQQQLQQ 8 87.5 5 0.625 597 604 63 QQQMQQYHQQLQVQQQQQPQPRAQPFRPPI IDLQAMNDRQFQQLADEIVAEDQMVQNAVD GO:0016651:oxidoreductase activity, acting on NADH or NADPH; --- --- --- >prot|C14B9.6b|cod|C14B9.6b|gene|C14B9.6|ann|gei-8 encodes a novel protein highly similar to C. briggsae BP:CBP04038 that contains a glutamine/asparagine (Q/N)-rich ('prion') domain (by the algorithm of Michelitsch and Weissman) and two myb-like DNA-binding domains. interacts with GEX-3 in yeast two-hybrid assays. [Source: WormBase] 1866 5 QQQHLQQQQQ 10 80 5 0.5 1362 1371 72 NLAVVYQNKMPQDREKLLQEQQLNQYLFAA HHGTQPEQKSKRKSGIESITSMQGAPHRHI --- --- --- --- >prot|W06F12.1a|cod|W06F12.1a|gene|W06F12.1|ann|lit-1 encodes a serine threonine protein kinase homolog related to the Drosophila protein Nemo that is required for embryonic viability, plays a central role in controlling the asymmetry of cell divisions during embryogenesis, and affects EMS, MS, and C lineages. acts downstream of mom-2 with respect to polarity defects and mediates larval cell fate decisions that involve POP-1, and is expressed in most embryonic and larval cells. [Source: WormBase] 634 1 QQQQQQQ 7 100 7 1 163 169 25 QPHYSAVVPRSDVIQQPPHFALHHHLQNLV AHHHHQQLVGEMALVSHTHPAAVGSTTCYE --- GO:0006836:neurotransmitter transport; GO:0005887:integral to plasma membrane;GO:0016020:membrane; --- >prot|H20J18.1b.1|cod|H20J18.1b.1|gene|H20J18.1|ann|scd-1 encodes a novel protein with several regions that are extremely glutamine (Q) rich, interspersed with other residues (usually alanine). SCD-1 affects signalling by proteins in the DAF-7/transforming growth factor (TGF)-beta pathway (DAF-1, DAF-8, and DAF-14), and the Q-rich regions of SCD-1 protein may mediate epigenetic changes of stably heritable tertiary conformation. [Source: WormBase] 909 3 QQQQQ 5 100 5 1 606 610 66 LQHALLQHANNSTNSASKATLHDIRFQAMA VAASGVGQGQTTLHPFIRPNDEPIINVEDD --- --- --- --- >prot|F13H8.5|cod|F13H8.5|gene|F13H8.5|ann|F13H8.5 encodes a protein with a domain of unknown function (DB. IPR002602) that is found in several worm proteins, and a glutamine/asparagine-rich domain. [Source: WormBase] 439 1 QPQQQQQ 7 85.7142857142857 5 0.714285714285714 89 95 20 QQQNYQQFLAQQQYQPQFQAQQQPQQPQYF PVQYQQQQPQQPLQYQQQPQPAPPPIYSQT --- --- --- --- >prot|F13H6.1a|cod|F13H6.1a|gene|F13H6.1|ann|F13H6.1 [Source:RefSeq_peptide;Acc:NP_504620] 690 1 QQQQQQQQQLQQQQQ 15 93.3333333333333 9 0.6 389 403 56 MQEYYASIQQMPYPMTNSTAVALLNISNNL NLIAAQPQVATPQPPAPTPLFQSLNRLSTA GO:0003700:sequence-specific DNA binding transcription factor activity;GO:0008270:zinc ion binding;GO:0043565:sequence-specific DNA binding; GO:0006355:regulation of transcription, DNA-dependent; --- --- >prot|Y71F9AL.11|cod|Y71F9AL.11|gene|Y71F9AL.11|ann|Y71F9AL.11 [Source:RefSeq_peptide;Acc:NP_491058] 196 1 QQQQQQ 6 100 6 1 133 138 67 ALSPPLNFSAPSVSLVAGRRINEHLGKAAT SRFVHDPHHHHLKRKKRTRILPCVTQFPII --- GO:0007186:G-protein coupled receptor protein signaling pathway; GO:0016021:integral to membrane; --- >prot|Y20F4.2|cod|Y20F4.2|gene|Y20F4.2|ann|Y20F4.2 [Source:RefSeq_peptide;Acc:NP_490917] 473 1 QNVQQQQQQQQ 11 81.8181818181818 8 0.727272727272727 325 335 68 DGSGTPSPYMEVSPPGMHDFNQDAGSLPNL EIYTNGGAPGGGYYHAPIGPRHSTGACGPR --- --- --- --- >prot|Y54E10BR.3|cod|Y54E10BR.3|gene|Y54E10BR.3|ann|Y54E10BR.3 [Source:RefSeq_peptide;Acc:NP_491091] 304 1 QQQQQQ 6 100 6 1 136 141 44 GREQQHTLEEFIRNMFRPDPRGAAEEAASA PHPNVTFSFQMPGGIGVQIHAHTAGGGGGN GO:0005230:extracellular ligand-gated ion channel activity; GO:0006811:ion transport; GO:0016021:integral to membrane;GO:0045211:postsynaptic membrane; --- >prot|F43E2.1|cod|F43E2.1|gene|F43E2.1|ann|F43E2.1 [Source:RefSeq_peptide;Acc:NP_495546] 467 1 QQQQQ 5 100 5 1 449 453 96 VAMHHQIQMMQGQMMQQQIVFTAPEMYYYS PHPIFGIQQSSQFF GO:0005515:protein binding; --- --- --- >prot|C45G7.4|cod|C45G7.4|gene|C45G7.4|ann|C45G7.4 [Source:RefSeq_peptide;Acc:NP_500203] 603 1 QQQQQQQ 7 100 7 1 135 141 22 VTVIEVPELVHNLPPPMAEVSSSATKIVTS PAVATKMPRHHVSKKMKALAKRTEESKHFR --- --- --- --- >prot|M117.4|cod|M117.4|gene|M117.4|ann|M117.4 [Source:RefSeq_peptide;Acc:NP_502238] 662 1 QREQAQQQQQQQQ 13 76.9230769230769 8 0.615384615384615 361 373 54 NRGGQVQKQPSKVVLQPGAPGATPVASTPN KGPMGLFKKIYRKMNFRAASDCTVEPTKEM --- --- --- --- >prot|F52G3.1.1|cod|F52G3.1.1|gene|F52G3.1|ann|F52G3.1 [Source:RefSeq_peptide;Acc:NP_510744] 1172 1 QQQQQQQQQQSSGQ 14 78.5714285714286 10 0.714285714285714 1017 1030 86 GQAPYFDRTTLPPANLAVGSQRQFSGNMNR SHPMNGMGNSNGGPQFPQQNFTQPPPPVMR --- --- --- --- >prot|Y57G11C.9a|cod|Y57G11C.9a|gene|Y57G11C.9|ann|Y57G11C.9b [Source:RefSeq_peptide;Acc:NP_502785] 553 1 QQQQQQQQ 8 100 8 1 402 409 72 EATPKMIVRETPQPAQPPVQVNSYYTTTPI PIPPQLPTALFGHLKAFQSALLSTVKYEPP --- --- --- --- >prot|ZC376.7a.2|cod|ZC376.7a.2|gene|ZC376.7|ann|ZC376.7b [Source:RefSeq_peptide;Acc:NP_872160] 488 1 QQQQQTCQQ 9 77.7777777777778 5 0.555555555555556 152 160 31 GKSTDCFELEAWRPTDSWQNGSSVGHPHGH PPTHSSTTETMHDFSNFGDNMGSPLFQSPS GO:0008324:cation transmembrane transporter activity; --- GO:0016020:membrane; --- >prot|Y48C3A.12|cod|Y48C3A.12|gene|Y48C3A.12|ann|Y48C3A.12 [Source:RefSeq_peptide;Acc:NP_496820] 675 1 QQQQQ 5 100 5 1 393 397 58 CGIPISGGGAAAQTSAPHSTPYGTPKDTHI PVVFEEILTANGPPPQPSSPLLPALITTTT --- --- --- --- >prot|W10D5.3c|cod|W10D5.3c|gene|W10D5.3|ann|gei-17 encodes a protein containing a MIZ domain (Msx-interacting-zinc finger) that affects embryonic viability, vulval development, and body morphology. interacts with GEX-3 in yeast two-hybrid assays. [Source: WormBase] 793 1 QQQQQQQPQ 9 88.8888888888889 7 0.777777777777778 131 139 16 RPATTSQVRSHPYVLPSRSGASNHLVNHHY PHNLLHQQMMASHHSHLQQQHHPSTVRWLT GO:0008270:zinc ion binding;GO:0003676:nucleic acid binding; --- --- --- >prot|C37E2.4|cod|C37E2.4|gene|C37E2.4|ann|ceh-36 encodes a paired-like homeodomain transcription factor that is one of three orthodenticle (OTD)-like homeodomain proteins in C. elegans (the others being ttx-1 and ceh-37). CEH-36 is required broadly for specification of the AWC olfactory neuron and also for establishing the left-right asymmetry of the ASEL and ASER gustatory neurons. in addition, CEH-36 is sufficient to specify the AFD thermosensory neuron fate in some cell types. CEH-36 is expressed in the AWC and ASE chemosensory neurons. [Source: WormBase] 257 1 QLQQQQQQQLQQ 12 83.3333333333333 7 0.583333333333333 174 185 67 TKSLGIHIPGTPEFNAHSAAKYEANSAVLS PKSELEDSKPLADTKYDSTQSLLPQAQAAA --- --- --- --- >prot|Y53C12B.3b|cod|Y53C12B.3b|gene|Y53C12B.3|ann|nos-3 encodes a homolog of Drosophila NANOS that physically interacts with FBF-1 (similar, though not orthologous, to Drosophila PUMILIO). NOS-3 is required in development of the hermaphrodite germ-line to promote the switch from sperm to oocyte production, perhaps by forming a complex with FBF-1 that controls fem-3 mRNA. [Source: WormBase] 871 2 QQFQQHSQQQQQ 12 75 5 0.416666666666667 4 15 0 MSGQQFQQHSQQQQQRAPTVYNNNNKKNGG RAPTVYNNNNKKNGGSAANSNQNNNNPHHT --- --- --- --- >prot|Y53C12B.3b|cod|Y53C12B.3b|gene|Y53C12B.3|ann|nos-3 encodes a homolog of Drosophila NANOS that physically interacts with FBF-1 (similar, though not orthologous, to Drosophila PUMILIO). NOS-3 is required in development of the hermaphrodite germ-line to promote the switch from sperm to oocyte production, perhaps by forming a complex with FBF-1 that controls fem-3 mRNA. [Source: WormBase] 871 2 QNQQQQQQ 8 87.5 6 0.75 305 312 35 PPPHNAQSYGQYRGPQGPQGQIIQMMPHNP HPMLYPMVYVPVPAPRVFRQEPAGGASSLE --- --- --- --- >prot|D2045.1c|cod|D2045.1c|gene|D2045.1|ann|atx-2 is required for early embryonic patterning. it encodes an ortholog of human ataxin-2, which when mutated leads to spinocerebellar ataxia 2 (SCA2. OMIM:183090). [Source: WormBase] 930 4 QQQQQ 5 100 5 1 251 255 26 DDDERDLDKITRQEDFENGNGRKRNNNSFN RRNPNIAPNGQPVNRRAEGLRGDRRNSGSS --- GO:0006869:lipid transport; --- --- >prot|D2045.1c|cod|D2045.1c|gene|D2045.1|ann|atx-2 is required for early embryonic patterning. it encodes an ortholog of human ataxin-2, which when mutated leads to spinocerebellar ataxia 2 (SCA2. OMIM:183090). [Source: WormBase] 930 4 QNQQQQQGQ 9 77.7777777777778 5 0.555555555555556 304 312 32 GLRGDRRNSGSSSANNSRYGAPAAAQQNYS KGYRRQNEENDWQMAKGKGQNQGHDHSFRQ --- GO:0006869:lipid transport; --- --- >prot|D2045.1c|cod|D2045.1c|gene|D2045.1|ann|atx-2 is required for early embryonic patterning. it encodes an ortholog of human ataxin-2, which when mutated leads to spinocerebellar ataxia 2 (SCA2. OMIM:183090). [Source: WormBase] 930 4 QQQQQQQQQQMHRQ 14 78.5714285714286 10 0.714285714285714 902 915 96 QHPQQSLMGERSDQGFPTSGYFDYRTMPNY NSLPQQFQGNQALKV --- GO:0006869:lipid transport; --- --- >prot|F55G1.1|cod|F55G1.1|gene|F55G1.1|ann|F55G1.1 [Source:RefSeq_peptide;Acc:NP_501205] 329 1 QQQQQHQQ 8 87.5 5 0.625 164 171 49 VKLRRNLTEIRKDIRNFETTTDFTTSQDWA HHEFQPNCSIPMQRHPISRSASFVAPTPMI --- --- --- --- >prot|C18H9.3|cod|C18H9.3|gene|C18H9.3|ann|C18H9.3 [Source:RefSeq_peptide;Acc:NP_495360] 918 2 QRTQQQQQQQQQQSTQQQAQ 20 75 10 0.5 251 270 27 SKVGSTSRTSTNAAPQSSERPAWARSESWI PPITLWNNREVGSDSTVWKDRNHMVAAVRK --- --- --- --- >prot|C18H9.3|cod|C18H9.3|gene|C18H9.3|ann|C18H9.3 [Source:RefSeq_peptide;Acc:NP_495360] 918 2 QQQQQQQQ 8 100 8 1 309 316 33 REVGSDSTVWKDRNHMVAAVRKASTENHPP RSSAPVSAPSRQESESTDVPNLPIPTYPSD --- --- --- --- >prot|C03D6.4|cod|C03D6.4|gene|C03D6.4|ann|npp-14 is orthologous to the human gene NUCLEOPORIN, 214-KD (NUP214. OMIM:114350), which encodes part of the nucleopore complex mediating nucleocytoplasmic transport. NUP214, as a fusion gene with DEK (OMIM:125264), is found in a subset of acute myeloid leukemia. [Source: WormBase] 1390 1 QQQQQQQ 7 100 7 1 1250 1256 89 TSGGNNPFAPKTSTGTSASSSSWLFGGGGN KPSFSFNTAGSSAQQASAPATGTSSVFGGA --- --- --- --- >prot|Y61A9LA.3a|cod|Y61A9LA.3a|gene|Y61A9LA.3|ann|Y61A9LA.3b [Source:RefSeq_peptide;Acc:NP_504240] 743 1 QHQQQQQQ 8 87.5 6 0.75 600 607 80 SLLDSVTMGMKVAAVAQMSQAQNPIQGGLF PMMSGGGGFVSGVQVVPMQVPMQSYQMPQM --- --- --- --- >prot|R74.5a|cod|R74.5a|gene|R74.5|ann|asd-1 encodes an ortholog of human RBM9 et al., and paralog of FOX-1 and SPN-4. ASD-1 isoforms have an RNA recognition motif and 1-2 glutamine/asparagine-rich domains. ASD-1 and FOX-1 both bind a site in egl-15 mRNA that is required to repress exon 5B splicing into mature mRNA. ASD-1 alone is partly required for exon 5A expression in muscle cells, while FOX-1 alone is dispensable for it. double asd-1.fox-1 mutants completely fail to express exon 5A in muscle cells, and have a synthetic egl-15 phenotype, while asd-1.spn-4 mutants do not. asd-1 is expressed pharyngeally. [Source: WormBase] 404 2 QQQQQQMQ 8 87.5 6 0.75 256 263 63 RHQQLMMPPTSAAAISQLQALQYQQALLAA NPQFLLSLQQQQQAQAQAPPTSMAQLIQHQ GO:0008270:zinc ion binding; --- GO:0005622:intracellular; --- >prot|R74.5a|cod|R74.5a|gene|R74.5|ann|asd-1 encodes an ortholog of human RBM9 et al., and paralog of FOX-1 and SPN-4. ASD-1 isoforms have an RNA recognition motif and 1-2 glutamine/asparagine-rich domains. ASD-1 and FOX-1 both bind a site in egl-15 mRNA that is required to repress exon 5B splicing into mature mRNA. ASD-1 alone is partly required for exon 5A expression in muscle cells, while FOX-1 alone is dispensable for it. double asd-1.fox-1 mutants completely fail to express exon 5A in muscle cells, and have a synthetic egl-15 phenotype, while asd-1.spn-4 mutants do not. asd-1 is expressed pharyngeally. [Source: WormBase] 404 2 QQQQQAQAQ 9 77.7777777777778 5 0.555555555555556 272 280 67 QLQALQYQQALLAAQQQQQQMQNPQFLLSL APPTSMAQLIQHQQQFAMDPMAQAQAQAAQ GO:0008270:zinc ion binding; --- GO:0005622:intracellular; --- >prot|ZK973.9|cod|ZK973.9|gene|ZK973.9|ann|ZK973.9 [Source:RefSeq_peptide;Acc:NP_491358] 233 1 QQQQQ 5 100 5 1 167 171 71 QPPHGFAPPPMGGGVPPEMMNHQAYQAQMR PNGQAPPPVYPPFGQPAPQMSGQRMPYPYP --- --- --- --- >prot|T04C4.1a|cod|T04C4.1a|gene|T04C4.1|ann|T04C4.1a [Source:RefSeq_peptide;Acc:NP_001023357] 955 1 QHQQQQQ 7 85.7142857142857 5 0.714285714285714 653 659 68 VDNDKMWEVPTEQPFSPCDVSNSPSTSCAH LKNGYQHPEETSSVAMMRRLRNNNQMDTSS --- --- --- --- >prot|Y53F4B.5|cod|Y53F4B.5|gene|Y53F4B.5|ann|Y53F4B.5 [Source:RefSeq_peptide;Acc:NP_497090] 144 1 QAIQQQQQ 8 75 5 0.625 34 41 23 QYPDESFLFQPRGGPPPGGPQDVPLQSMPP SLASEMIARDRLEHIVKHVKKYPFNCPYCR --- --- --- --- >prot|K04G2.8a|cod|K04G2.8a|gene|K04G2.8|ann|The apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis. APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells). however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39. [Source: WormBase] 1186 3 QLQQQQQ 7 85.7142857142857 5 0.714285714285714 543 549 45 RHFAVQRNGFVMAQSYNQQMDQHQQQQMIY IMTEDQAQMEHHQQIMYLQQQQQQFHQIQQ --- --- --- --- >prot|K04G2.8a|cod|K04G2.8a|gene|K04G2.8|ann|The apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis. APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells). however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39. [Source: WormBase] 1186 3 QQQQQQ 6 100 6 1 568 573 47 QQMIYQLQQQQQIMTEDQAQMEHHQQIMYL FHQIQQQQQMQKAQEADPVPPTDDDLDIPT --- --- --- --- >prot|K04G2.8a|cod|K04G2.8a|gene|K04G2.8|ann|The apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis. APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells). however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39. [Source: WormBase] 1186 3 QQQQQQFHQIQQQQQMQ 17 76.4705882352941 6 0.352941176470588 568 584 47 QQMIYQLQQQQQIMTEDQAQMEHHQQIMYL KAQEADPVPPTDDDLDIPTSTVMGTRSNSE --- --- --- --- >prot|F40F9.7b.1|cod|F40F9.7b.1|gene|F40F9.7|ann|F40F9.7b [Source:RefSeq_peptide;Acc:NP_001023907] 305 1 QQQQQ 5 100 5 1 21 25 6 MSTLASTSSAGASSSTGSSNQQQQQAAAVI AAAVIRRRRFSTAKIQPTRIKKVMQSDEDI --- --- --- --- >prot|C07G1.4b|cod|C07G1.4b|gene|C07G1.4|ann|wsp-1 encodes a homolog of human WASP that interacts with Arp2/3 and is required for hypodermal cell migration during morphogenesis (ventral enclosure). when mutated, human WASP leads to Wiskott-Aldrich syndrome (OMIM:301000). [Source: WormBase] 781 1 QQKQLQQQHHQQQQQQ 16 75 6 0.375 181 196 23 GGSTGTYARRQNYARCYVPISADAFYYYHN LAFRPRHRSSHHHQEPRRHRAPSPDPDYSP --- --- --- --- >prot|C11D9.1|cod|C11D9.1|gene|C11D9.1|ann|C11D9.1 [Source:RefSeq_peptide;Acc:NP_491367] 569 1 QQIQPQQQQQ 10 80 5 0.5 45 54 7 DMNTMGSSMASTSQYHQIPIQIQNQNPLPS YHPPDHVTTHNGTTTFHTTNPTKPRLCEGS --- GO:0007264:small GTPase mediated signal transduction;GO:0015031:protein transport; GO:0005622:intracellular; --- >prot|C50F2.3|cod|C50F2.3|gene|C50F2.3|ann|C50F2.3 [Source:RefSeq_peptide;Acc:NP_491250] 855 1 QQQQQ 5 100 5 1 772 776 90 VTLTSVQMRVDAERKAQETTTSSNPMDSLD PSDGAGSITQVSMNKGNISFVRGAGKTVQQ GO:0003682:chromatin binding;GO:0003676:nucleic acid binding;GO:0004386:helicase activity;GO:0005524:ATP binding;GO:0008026:ATP-dependent helicase activity; GO:0006333:chromatin assembly or disassembly; GO:0000785:chromatin;GO:0005634:nucleus; --- >prot|Y76B12C.6|cod|Y76B12C.6|gene|Y76B12C.6|ann|Y76B12C.6 [Source:RefSeq_peptide;Acc:NP_500155] 540 1 QQQQQ 5 100 5 1 502 506 92 GSLGLLSELDRARDVLDAVPPLPPGGIHGA AVRKRPDSHQQQQSEENRRKRMSTGARSVC --- --- --- --- >prot|Y57G11C.9b|cod|Y57G11C.9b|gene|Y57G11C.9|ann|Y57G11C.9b [Source:RefSeq_peptide;Acc:NP_502785] 625 1 QQQQQQQQ 8 100 8 1 402 409 64 EATPKMIVRETPQPAQPPVQVNSYYTTTPI PIPPQLPTAPPQPPPTTPQPAFVPRQIGRI --- --- --- --- >prot|F57B10.1.1|cod|F57B10.1.1|gene|F57B10.1|ann|F57B10.1 [Source:RefSeq_peptide;Acc:NP_491897] 690 1 QNQQQQQ 7 85.7142857142857 5 0.714285714285714 170 176 24 YSKDDDYEICSSGPLLAYTNANSVATSAVH RRLNQAGFPHQNSNGLVRFKSSQPRVLNPA GO:0005515:protein binding;GO:0003707:steroid hormone receptor activity;GO:0008270:zinc ion binding;GO:0043565:sequence-specific DNA binding; GO:0006355:regulation of transcription, DNA-dependent; GO:0005634:nucleus; --- >prot|F01D5.8|cod|F01D5.8|gene|F01D5.8|ann|F01D5.8 [Source:RefSeq_peptide;Acc:NP_496938] 305 1 QQQQQ 5 100 5 1 292 296 95 GKYIHVFTRIANFLRNETLVSCRSAEVDSS LSSKRTENE --- GO:0006810:transport; GO:0016021:integral to membrane; --- >prot|W04B5.3c|cod|W04B5.3c|gene|W04B5.3|ann|W04B5.3b [Source:RefSeq_peptide;Acc:NP_741096] 353 1 QQQQQQ 6 100 6 1 344 349 97 PQPLPQQMSRQQAPIYQNQQQMPPGYNPYL MAVI --- GO:0007156:homophilic cell adhesion; GO:0016020:membrane; --- >prot|K09H11.4|cod|K09H11.4|gene|K09H11.4|ann|K09H11.4 [Source:RefSeq_peptide;Acc:NP_504504] 630 1 QQQQQQ 6 100 6 1 380 385 60 ERRSHGSEERRGGSEEQPHREERGPQKPEG APSPPKPQIPPFPAFPKFPSFGGFQPFQPD --- --- --- --- >prot|C49H3.5b|cod|C49H3.5b|gene|C49H3.5|ann|ntl-4 encodes two proteins by alternative splicing, one of which (NTL-4A) has an N-terminal RING finger and a RNA recognition motif ('RRM', 'RBD', or 'RNP'), and both of which have glutamine/asparagine-rich domains. [Source: WormBase] 615 3 QQQQQSQQQRQ 11 81.8181818181818 5 0.454545454545455 413 423 67 QLHAQQQHQQQQFAADMNRQQDYMYSRLMS FDSTPGFSHPFGSMQQQQQSSQQQQHQSQS --- --- --- --- >prot|C49H3.5b|cod|C49H3.5b|gene|C49H3.5|ann|ntl-4 encodes two proteins by alternative splicing, one of which (NTL-4A) has an N-terminal RING finger and a RNA recognition motif ('RRM', 'RBD', or 'RNP'), and both of which have glutamine/asparagine-rich domains. [Source: WormBase] 615 3 QQQQQ 5 100 5 1 438 442 71 SRLMSQQQQQSQQQRQFDSTPGFSHPFGSM SSQQQQHQSQSSQSSSLLQDLFNRQQQQHQ --- --- --- --- >prot|C49H3.5b|cod|C49H3.5b|gene|C49H3.5|ann|ntl-4 encodes two proteins by alternative splicing, one of which (NTL-4A) has an N-terminal RING finger and a RNA recognition motif ('RRM', 'RBD', or 'RNP'), and both of which have glutamine/asparagine-rich domains. [Source: WormBase] 615 3 QQSQQQQQQQQ 11 90.9090909090909 8 0.727272727272727 532 542 86 VPFGMAPPPGLGGPSTNRSSTTQQAPPHMT SSMGLFGMGGHQSMMQDHQSQQPQSAQDAF --- --- --- --- >prot|K04G2.8b|cod|K04G2.8b|gene|K04G2.8|ann|The apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis. APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells). however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39. [Source: WormBase] 1188 3 QLQQQQQ 7 85.7142857142857 5 0.714285714285714 543 549 45 RHFAVQRNGFVMAQSYNQQMDQHQQQQMIY IMFQTEDQAQMEHHQQIMYLQQQQQQFHQI --- --- --- --- >prot|K04G2.8b|cod|K04G2.8b|gene|K04G2.8|ann|The apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis. APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells). however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39. [Source: WormBase] 1188 3 QQQQQQ 6 100 6 1 570 575 47 MIYQLQQQQQIMFQTEDQAQMEHHQQIMYL FHQIQQQQQMQKAQEADPVPPTDDDLDIPT --- --- --- --- >prot|K04G2.8b|cod|K04G2.8b|gene|K04G2.8|ann|The apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis. APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells). however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39. [Source: WormBase] 1188 3 QQQQQQFHQIQQQQQMQ 17 76.4705882352941 6 0.352941176470588 570 586 47 MIYQLQQQQQIMFQTEDQAQMEHHQQIMYL KAQEADPVPPTDDDLDIPTSTVMGTRSNSE --- --- --- --- >prot|C06G1.6|cod|C06G1.6|gene|C06G1.6|ann|Putative uncharacterized protein. [Source:UniProtKB/TrEMBL;Acc:B1Q237] 792 1 QQQQQQ 6 100 6 1 268 273 33 REYHNSTPHQYQHSSSLGGPPLPLPRESSL AHPFENRSEFHRHPPPPPPPSSSSSHQFYN --- --- --- --- >prot|R06F6.12|cod|R06F6.12|gene|R06F6.12|ann|Uncharacterized protein R06F6.12. [Source:UniProtKB/Swiss-Prot;Acc:Q6BEV5] 417 1 QQQQQ 5 100 5 1 57 61 13 VYPADEDHIFHEDQAPLRVESAKHEEEIVE PEDLEQGDMIVEDGDQQFMNMVQITQEDMY --- --- --- --- >prot|C27B7.4|cod|C27B7.4|gene|C27B7.4|ann|RADiation sensitivity abnormal/yeast RAD-related family member (rad-26) [Source:RefSeq_peptide;Acc:NP_501545] 1274 1 QLQQQQQQQQQQLQ 14 85.7142857142857 10 0.714285714285714 653 666 51 WNHPDILYRLVEQKKRAEEDKKRVEQMKFA GMMMMGNNGMMPGFGAQFHPQQNGMMMQNG --- --- --- --- >prot|F54B11.4|cod|F54B11.4|gene|F54B11.4|ann|Putative uncharacterized protein. [Source:UniProtKB/TrEMBL;Acc:Q20740] 209 1 QQQQQQQQQNQ 11 90.9090909090909 9 0.818181818181818 73 83 34 EISSFLPSYSPFQQQLQFQQLQQSRNLLSL ALISSPHNPTLLPDVIAIPKRETGNSLNFL --- --- --- --- >prot|Y71F9B.10a.2|cod|Y71F9B.10a.2|gene|Y71F9B.10|ann|The sop-3 gene encodes a novel protein that regulates Hox gene expression by modulating Wnt signaling. [Source: WormBase] 1475 2 QMQQQQQQQFQMQ 13 76.9230769230769 7 0.538461538461538 787 799 53 SSSEQHNPNPHQMSQYQMQQYQQNQQFRMH SPKNPLVPAYTDEDSDEECDPPPPPKPQVS GO:0016303:1-phosphatidylinositol-3-kinase activity;GO:0016773:phosphotransferase activity, alcohol group as acceptor;GO:0004428:inositol or phosphatidylinositol kinase activity;GO:0046934:phosphatidylinositol-4,5-bisphosphate 3-kinase activity; GO:0007568:aging;GO:0040024:dauer larval development;GO:0046854:phosphoinositide phosphorylation;GO:0048015:phosphoinositide-mediated signaling;GO:0007165:signal transduction; --- --- >prot|Y71F9B.10a.2|cod|Y71F9B.10a.2|gene|Y71F9B.10|ann|The sop-3 gene encodes a novel protein that regulates Hox gene expression by modulating Wnt signaling. [Source: WormBase] 1475 2 QQQQQ 5 100 5 1 1249 1253 84 SSSTESKKEPPSAAPITRKESTTAPVAPAV RKESFTALPSLPEQQQHHREPLLKKKPPLQ GO:0016303:1-phosphatidylinositol-3-kinase activity;GO:0016773:phosphotransferase activity, alcohol group as acceptor;GO:0004428:inositol or phosphatidylinositol kinase activity;GO:0046934:phosphatidylinositol-4,5-bisphosphate 3-kinase activity; GO:0007568:aging;GO:0040024:dauer larval development;GO:0046854:phosphoinositide phosphorylation;GO:0048015:phosphoinositide-mediated signaling;GO:0007165:signal transduction; --- --- >prot|F33H1.4|cod|F33H1.4|gene|F33H1.4|ann|F33H1.4 [Source:RefSeq_peptide;Acc:NP_496194] 1378 1 QQIRQHQQQQQQ 12 75 6 0.5 673 684 48 TGALVEPHNMVEQEQQVMQEEVEQEDVKNK EVPGGQEGAGPVDRGNLEFSFLDTNNICCG --- --- --- ---