This page explains the different fields available in the data base. When the word "protein" is used we refer to the polypeptide chain used in the experiment

Protein fields: describe parameters aimed at identifying the protein used

• Protein name: the common name of the protein.
• Protein ID: the Uniprot code associated to the protein.
• Start: given the Uniprot code, this indicate the position of the the first residue of the protein.
• Stop: given the Uniprot code, this indicate the position of the the last residue of the protein.
• Length: the length of the protein in # of residues.
• MW (Da): mole cular weight of the protein in KDa.
• Organism: the name of the organism in whose genome is present the protein used (not th eexpression host etc.). Accepted values a r eboth common names, scientific names or taxonomic IDs

Mutation fields: describe possible modifications introduced in the protein sequence

• Mutation type: the type of modification introduced in the protein. Accepted fields are "substitution" "insertion" "deletion".
  
• Position: the position at which the mutation has been inserted.
  
• Mutation: the mutation introduced in the protein. Accepted formats are e.g. "V25A" for a point substitution, "ins17:L" for an point insertion, "Δ17-25" for a block deletion, "Δ17-25:ARF" for a block replacement
• Hot spot: wether a mutations alters an hot-spot of aggregation i.e. a region recognized as important for the aggregation process
• Fitting method: the regression method used to derive the kinetic constants, e.g. single exponential, logistic etc.
• Technique: the technique used to monitor the aggregation process. Examples are thioflavin T (ThT), circular dichroism (CD) etc.

Condition fields

• pH: the pH of the buffer where the aggregation process occurred
• Protein conc (μM): the proitein concentration used in the aggregation experiment expressed in μM units
• Protein conc (mg/ml): the proitein concentration used in the aggregation experiment epresse in mg/ml units
• Ionic strength (mM): the ionic strength of the buffer where the aggregation process occurred
• TFE %: if any TFE is added as a cosolvent, this filed specify its concentration in %
• Temp (°C): the tenmperature at which the aggregation process occurred

Kinetic fields

• Lag phase (s): the estimated time for the lag phase of the aggregation process in seconds
• t 1/2 (s): the half time at which aggregation signal is half with respect to the plateau
• Exp phase (s^-1): he aggregation rate as measured in a fitting with an exponential function

End product

• what forms at the end of the aggregation process. Accepted values are "oligomers" or "fibrils"